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Mouse IL-1β(Interleukin 1 Beta) ELISA Kit

  • Cat.No.:E-EL-M0037

  • Reactivity: Mouse

To Purchase E-EL-M0037

  • 96T
  • 48T
  • 24T
  • 96T*5
  • 96T*10
Price: $495

Product Details


Assay type Sandwich-ELISA
Format 96T/48T
Assay time 3.5h
Detection range 7.81-500 pg/mL
Sensitivity 4.69 pg/mL
Sample type &Sample volume serum, plasma and other biological fluids; 100μL
Specificity This kit recognizes Mouse IL-1β in samples. No significant cross-reactivity or interference between Mouse IL-1β and analogues was observed.
Reproducibility Both intra-CV and inter-CV are < 10%.
Application This ELISA kit applies to the in vitro quantitative determination of Mouse IL-1β concentrations in serum, plasma and other biological fluids.

Test Principle

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse IL-1β. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Mouse IL-1β and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse IL-1β, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of Mouse IL-1β. You can calculate the concentration of Mouse IL-1β in the samples by comparing the OD of the samples to the standard curve.

Kit components & Storage

An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the components separately according to the following conditions once the kit is received.
Micro ELISA Plate(Dismountable) 96T: 8 wells ×12 strips
48T: 8 wells ×6 strips
-20℃, 6 months
Reference Standard 96T: 2 vials
48T: 1 vial
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
-20℃(Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL
HRP Conjugate Diluent 1 vial, 14 mL
Concentrated Wash Buffer (25×) 1 vial, 30 mL
Substrate Reagent 1 vial, 10 mL 2-8℃(Protect from light)
Stop Solution 1 vial, 10 mL 2-8°C
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Technical Data


Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Mouse IL-1β were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Mouse IL-1β were tested on 3 different plates, 20 replicates in each plate.

  Intra-assay Precision Inter-assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (pg/mL) 26.40 59.30 201.20 27.30 57.80 199.40
Standard deviation 1.70 3.20 10.10 1.80 2.40 8.80
CV (%) 6.44 5.40 5.02 6.59 4.15 4.41


The recovery of Mouse IL-1β spiked at three different levels in samples throughout the range of the assay was evaluated in various matrices.

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 88-103 96
EDTA plasma (n=8) 91-104 97
Cell culture media (n=8) 91-107 98


Samples were spiked with high concentrations of Mouse IL-1β and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

Target Information

Database LinksSwissProt:   P10749
SynonymsIL1B, IL1-BETA, IL1F2, catabolin
Research AreaCancer, Cardiovascular, Metabolism, Immunology

Assay Procedures

elisa assay procedure 1

1. Add 100μL standard or sample to the wells. Incubate for 90 min at 37°C

elisa assay procedure 2

2. Discard the liquid, immediately add 100μL Biotinylated Detection Ab working solution to each well. Incubate for 60 min at 37°C

elisa assay procedure 3

3. Aspirate and wash the plate for 3 times

elisa assay procedure 4

4. Add 100μL HRP conjugate working solution. Incubate for 30 min at 37°C. Aspirate and wash the plate for 5 times

elisa assay procedure 5

5. Add 90μL Substrate Reagent. Incubate for 15 min at 37°C

elisa assay procedure 6

6. Add 50μL Stop Solution

elisa assay procedure 7

7. Read the plate at 450nm immediately. Calculation of the results


From now on, if you have published a paper by using any of our products since 1/1/2019, fill out the “Elabscience Publication Reward Application Form”carefully and send it to, we will get back to you with the reward after we confirm it ASAP!

View more details about our Publication Reward >>

  1. Molecular Cell (2017) IF: 14.714
    Celastrol-Induced Nur77 Interaction With TRAF2 Alleviates Inflammation By Promoting Mitochondrial Ubiquitination And Autophagy.

    DOI: 10.1016/j.molcel.2017.03.008

    PMID: 28388439

    Sample: Serum
  2. Journal Of Nanobiotechnology (2021) IF: 10.435
    Gold nanoparticles reduce inflammation in cerebral microvessels of mice with sepsis

    DOI: 10.1186/s12951-021-00796-6

    PMID: 33608025

    Sample: Tissue(brain)
  3. Journal of Controlled Release (2021) IF: 9.776
    Simultaneous blockage of contextual TGF-β by cyto-pharmaceuticals to suppress breast cancer metastasis

    DOI: 10.1016/j.jconrel.2021.06.012

    PMID: 34119557

    Sample: Serum
  4. Bone research (2018) IF: 9.3260
    Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines.

    DOI: 10.1038/s41413-018-0012-0

    PMID: 29619269

  5. British Journal of Pharmacology (2020) IF: 7.73
    Protective effect of cilastatin against diclofenac-induced nephrotoxicity through interaction with diclofenac acyl glucuronide via organic anion transporters

    DOI: 10.1111/bph.14957

    PMID: 32000294

    Sample: Tissue homogenate
  6. Antioxidants (2022) IF: 6.312
    Therapeutic Potential of Perillaldehyde in Ameliorating Vulvovaginal Candidiasis by Reducing Vaginal Oxidative Stress and Apoptosis

    DOI: 10.3390/antiox11020178020178

    PMID: 35204061

    Sample: Tissue homogenate
  7. Free Radical Biology and Medicine (2020) IF: 6.17
    Dry eye induced by exposure to cigarette smoke pollution: An in vivo and in vitro study

    DOI: 10.1016/j.freeradbiomed.2020.04.007

    PMID: 32320747

    Sample: Cell lysate,Cell culture supernatant
  8. Free Radical Biology and Medicine (2019) IF: 6.17
    Oral administration of 3,3'-diselenodipropionic acid prevents thoracic radiation induced pneumonitis in mice by suppressing NF-kB/IL-17/G-CSF/neutrophil axis

    DOI: 10.1016/j.freeradbiomed.2019.09.009

    PMID: 31521664

    Sample: Bronchoalveolar Lavage Fluid,Tissue homogenate
  9. Analytical chemistry (2018) IF: 6.042
    A Redox-Responsive Self-Assembled Nanoprobe for Photoacoustic Inflammation Imaging to Assess Atherosclerotic Plaque Vulnerability

    DOI: 10.1021/acs.analchem.8b04912

    PMID: 30497260

    Sample: Cell culture supernatant
  10. British Journal of Pharmacology (2017) IF: 6.81
    The TIR/BB-loop mimetic AS-1 prevents nonalcoholic steatohepatitis and hepatic insulin resistance by inhibiting NLRP3-ASC inflammasome activation.

    DOI: 10.1111/bph.13786

    PMID: 28306139

    Sample: Cell culture supernatant
  11. Frontiers in Pharmacology (2021) IF: 5.8
    Oroxylin a Attenuates Limb Ischemia by Promoting Angiogenesis via Modulation of Endothelial Cell Migration

    DOI: 10.3389/fphar.2021.705617

    PMID: 34413777

    Sample: Serum,Tissue homogenate
  12. Lipids (2020) IF: 5.219
    Lipofundin Mediates the Major Inhibition of Intravenous Propofol in IL-1β Secretion and Phagocytosis of Staphylococcus aureus-Infected Macrophages

    DOI: 10.1002/lipd.12207

    PMID: 31838756

    Sample: Cell culture medium
  13. Frontiers in immunology (2019) IF: 5.085
    Intranasal MMI-0100 Attenuates Aβ 1-42- and LPS-Induced Neuroinflammation and Memory Impairments via the MK2 Signaling Pathway

    DOI: 10.3389/fimmu.2019.02707

    PMID: 31849936

    Sample: Tissue homogenate
  14. Neurotherapeutics (2018) IF: 5.719
    Spatial Training Ameliorates Long-Term Alzheimer's Disease-Like Pathological Deficits by Reducing NLRP3 Inflammasomes in PR5 Mice

    DOI: 10.1007/s13311-018-00698-w

    PMID: 30560481

    Sample: Tissue homogenate
  15. Oncotarget (2017) IF: 5.168
    Wu-tou Decoction Attenuates Neuropathic Pain Via Suppressing Spinal Astrocytic IL-1R1/TRAF6/JNK Signaling.

    DOI: 10.18632/oncotarget.21638

    PMID: 29190962

    Sample: Tissue homogenate
  16. British Journal of Pharmacology (2017) IF: 5.491
    The TIR/BB-Loop Mimetic AS-1 Prevents Non-Alcoholic Steatohepatitis And Hepatic Insulin Resistance By Inhibiting NLRP3-ASC Inflammasome Activation.

    DOI: 10.1111/bph.13786

    PMID: 28306139

    Sample: Cell culture supernatant
  17. Biochimica Et Biophysica Acta-Molecular Basis of Disease (2017) IF: 5.476
    A Novel Mechanism Of Diabetic Vascular Endothelial Dysfunction: Hypoadiponectinemia-Induced NLRP3 Inflammasome Activation.

    DOI: 10.1016/j.bbadis.2017.02.012

    PMID: 28216285

    Sample: Serum,Cell culture supernatant
  18. Biochimica Et Biophysica Acta-Molecular Basis of Disease (2016) IF: 5.476
    The TIR/BB-Loop Mimetic AS-1 Attenuates Mechanical Stress-Induced Cardiac Fibroblast Activation And Paracrine Secretion Via Modulation Of Large Tumor Suppressor Kinase 1.

    DOI: 10.1016/j.bbadis.2016.03.002

    PMID: 26964796

    Sample: Cell culture supernatant
  19. Molecules (2022) IF: 4.411
    The Expression and Bioinformatics Analysis of Circular RNAs in Endometritis Mouse Uterus Tissues

    DOI: 10.3390/molecules27123682

    Sample: Tissue homogenate
  20. Food & Function (2020) IF: 4.171
    Melatonin as an inducer of arecoline and their coordinated roles in anti-oxidative activity and immune responses

    DOI: 10.1039/d0fo01841d

    PMID: 32955540

    Sample: Plasma
  21. Food & Function (2020) IF: 4.171
    Flaxseed oligosaccharides alleviate DSS-induced colitis through modulation of gut microbiota and repair of the intestinal barrier in mice

    DOI: 10.1039/d0fo01105c

    PMID: 32856645

    Sample: Serum,Tissue homogenate
  22. Aging (2020) IF: 4.831
    Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1)

    DOI: 10.18632/aging.103852

    PMID: 32950974

    Sample: Serum
  23. ACS Chemical Neuroscience (2020) IF: 4.486
    MG53 Protects hUC-MSCs against Inflammatory Damage and Synergistically Enhances Their Efficacy in Neuroinflammation Injured Brain through Inhibiting NLRP3/Caspase-1/IL-1β Axis

    DOI: 10.1021/acschemneuro.0c00268

    PMID: 32786312

    Sample: Serum
  24. Neuropharmacology (2020) IF: 4.431
    Seizure-induced neuroinflammation contributes to ectopic neurogenesis and aggressive behavior in pilocarpine-induced status epilepticus mice

    DOI: 10.1016/j.neuropharm.2020.108044

    PMID: 32179291

    Sample: Cell lysate
  25. Ecotoxicology and Environmental Safety (2020) IF: 4.872
    Silica particles disorganize the polarization of pulmonary macrophages in mice

    DOI: 10.1016/j.ecoenv.2020.110364

    PMID: 32114243

    Sample: Tissue homogenate
  26. Aging (2020) IF: 4.831
    Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis

    DOI: 10.18632/aging.103215

    PMID: 32432571

    Sample: Cell culture supernatant,Tissue homogenate
  27. Frontiers in Cellular and Infection Microbiology (2020) IF: 4.123
    Extracellular Histone H3 Induces Pyroptosis During Sepsis and May Act Through NOD2 and VSIG4/NLRP3 Pathways

    DOI: 10.3389/fcimb.2020.00196

    PMID: 32432055

    Sample: Cell culture supernatant
  28. Biomolecules (2020) IF: 4.082
    Preparation, Characterization, and Immuno-Enhancing Activity of Polysaccharides from Glycyrrhiza uralensis

    DOI: 10.3390/biom10010159

    PMID: 31963790

    Sample: Cell culture supernatant,Cell sample
  29. Biomedicine & Pharmacotherapy (2019) IF: 4.545
    Inhibition of HDAC6 attenuates LPS-induced inflammation in macrophages by regulating oxidative stress and suppressing the TLR4-MAPK/NF-κB pathways

    DOI: 10.1016/j.biopha.2019.109166

    PMID: 31255993

    Sample: Cell culture supernatant
  30. The Journal of nutrition (2019) IF: 4.281
    Lactobacillus acidophilus Exerts Neuroprotective Effects in Mice with Traumatic Brain Injury

    DOI: 10.1093/jn/nxz105

    PMID: 31174208

    Sample: Serum,Tissue homogenate
  31. ACS chemical neuroscience (2019) IF: 4.486
    Liproxstatin-1 Attenuates Morphine Tolerance through Inhibiting Spinal Ferroptosis-like Cell Death

    DOI: 10.1021/acschemneuro.9b00539

    PMID: 31682397

    Sample: Tissue homogenate
  32. Scientific reports (2018) IF: 4.122
    Ageratina adenophora induces mice hepatotoxicity via ROS-NLRP3-mediated pyroptosis

    DOI: 10.1038/s41598-018-34492-7

    PMID: 30375483

    Sample: Serum,Tissue homogenate
  33. Scientific Reports (2017) IF: 4.259
    Glycyrrhiza Uralensis Water Extract Enhances Dendritic Cell Maturation And Antitumor Efficacy Of HPV Dendritic Cell-Based Vaccine.

    DOI: 10.1038/srep43796

    PMID: 28272545

    Sample: Cell culture supernatant
  34. Frontiers in Aging Neuroscience (2015) IF: 4.504
    PGC-1α Silencing Compounds The Perturbation Of Mitochondrial Function Caused By Mutant SOD1 In Skeletal Muscle Of ALS Mouse Model.

    DOI: 10.3389/fnagi.2015.00204

    PMID: 26539112

    Sample: Serum
  35. Neurochemistry International (2020) IF: 3.881
    Hesperidin alleviates chronic restraint stress and lipopolysaccharide-induced Hippocampus and Frontal cortex damage in mice: Role of TLR4/NF-κB, p38 MAPK/JNK, Nrf2/ARE signaling

    DOI: 10.1016/j.neuint.2020.104835

    PMID: 32853749

    Sample: Serum
  36. Life Sciences (2020) IF: 3.647
    Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways

    DOI: 10.1016/j.lfs.2020.118546

    PMID: 33035580

    Sample: Serum
  37. Life Sciences (2020) IF: 3.647
    DHCR24 overexpression modulates microglia polarization and inflammatory response via Akt/GSK3β signaling in Aβ 25-35 treated BV-2 cells

    DOI: 10.1016/j.lfs.2020.118470

    PMID: 32950573

    Sample: Cell sample
  38. Life Sciences (2020) IF: 3.647
    Fenugreek attenuates obesity-induced inflammation and improves insulin resistance through downregulation of iRhom2/TACE

    DOI: 10.1016/j.lfs.2020.118222

    PMID: 32768577

    Sample: Serum
  39. Life Sciences (2020) IF: 3.647
    Sevoflurane up-regulates microRNA-204 to ameliorate myocardial ischemia/reperfusion injury in mice by suppressing Cotl1

    DOI: 10.1016/j.lfs.2020.118162

    PMID: 32730836

    Sample: Tissue homogenate
  40. International Immunopharmacology (2020) IF: 3.943
    miR-129-5p alleviates LPS-induced acute kidney injury via targeting HMGB1/TLRs/NF-kappaB pathway

    DOI: 10.1016/j.intimp.2020.107016

    PMID: 33039954

    Sample: Serum
  41. International Immunopharmacology (2020) IF: 3.943
    Myricitrin pretreatment ameliorates mouse liver ischemia reperfusion injury

    DOI: 10.1016/j.intimp.2020.107005

    PMID: 33045574

    Sample: Serum
  42. International Immunopharmacology (2020) IF: 3.943
    COX-2-PGE 2 signaling pathway contributes to hippocampal neuronal injury and cognitive impairment in PTZ-kindled epilepsy mice

    DOI: 10.1016/j.intimp.2020.106801

    PMID: 32702600

    Sample: Tissue homogenate
  43. European Review for Medical and Pharmacological Sciences (2020) IF: 3.024
    miR-181-5p protects mice from sepsis via repressing HMGB1 in an experimental model

    DOI: 10.26355/eurrev_202009_23063

    PMID: 33015817

    Sample: Serum
  44. European review for medical and pharmacological sciences (2020) IF: 3.024
    Effect of β-casomorphin-7 on myocardial hypertrophy in hyperthyroidism-induced cardiomyopathy

    DOI: 10.26355/eurrev_202006_21536

    PMID: 32572935

    Sample: Serum,Tissue homogenate
  45. European Journal of Pharmacology (2020) IF: 3.263
    iTRAQ-based proteomics and in vitro experiments reveals essential roles of ACE and AP-N in the renin-angiotensin system-mediated congenital ureteropelvic junction obstruction

    DOI: 10.1016/j.yexcr.2020.112086

    PMID: 32416091

    Sample: Serum,Cell sample
  46. Brain Research Bulletin (2020) IF: 3.37
    Biological evaluation of naturally occurring bulbocodin D as a potential multi-target agent for Alzheimer's disease

    DOI: 10.1016/j.brainresbull.2020.09.017

    PMID: 32991975

    Sample: Cell culture supernatant
  47. American Journal of Translational Research (2020) IF: 3.375
    Overexpression of lncRNA Gm43050 alleviates apoptosis and inflammation response induced by sevoflurane treatment by regulating miR-640/ZFP91

    PMID: 32913509

    Sample: Cell culture supernatant
  48. Journal of Drug Targeting (2020) IF: 3.38
    Development, optimisation and evaluation of chitosan nanoparticles of alendronate against Alzheimer's disease in intracerebroventricular streptozotocin model for brain delivery

    DOI: 10.1080/1061186X.2020.1817041

    PMID: 32876502

    Sample: Tissue homogenate
  49. Experimental Biology and Medicine (2020) IF: 3.139
    Exosomes derived from synovial fibroblasts under hypoxia aggravate rheumatoid arthritis by regulating Treg/Th17 balance

    DOI: 10.1177/1535370220934736

    PMID: 32615822

    Sample: Cell culture medium
  50. Neurochemical Research (2020) IF: 3.038
    Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage

    DOI: 10.1007/s11064-020-03012-3

    PMID: 32170675

    Sample: Tissue homogenate
  51. International Immunopharmacology (2020) IF: 3.943
    4-hydroxybenzo[d]oxazol-2(3H)-one ameliorates LPS/D-GalN-induced acute liver injury by inhibiting TLR4/NF-κB and MAPK signaling pathways in mice

    DOI: 10.1016/j.intimp.2020.106445

    PMID: 32272395

    Sample: Tissue homogenate
  52. Investigative Ophthalmology & Visual Science (2020) IF: 3.47
    Honokiol Reduces Fungal Load, Toll-Like Receptor-2, and Inflammatory Cytokines in Aspergillus fumigatus Keratitis

    DOI: 10.1167/iovs.61.4.48

    PMID: 32347916

    Sample: Cell culture supernatant
  53. IUBMB life (2020) IF: 3.244
    Blockade of high mobility group box 1 involved in the protective of curcumin on myocardial injury in diabetes in vivo and in vitro

    DOI: 10.1002/iub.2226

    PMID: 31909882

    Sample: Serum
  54. International Immunopharmacology (2020) IF: 3.943
    Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation

    DOI: 10.1016/j.intimp.2019.106181

    PMID: 31926446

    Sample: Cell sample,Tissue homogenate
  55. Scientific reports (2020) IF: 3.998
    Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway

    DOI: 10.1038/s41598-020-66789-x

    PMID: 32555320

    Sample: Serum
  56. Journal of Functional Foods (2020) IF: 3.701
    Anti-fatigue activity of purified anthocyanins prepared from purple passion fruit (P. edulis Sim) epicarp in mice

    DOI: 10.1016/j.jff.2019.103725

    Sample: Tissue homogenate
  57. International Immunopharmacology (2020) IF: 3.943
    Inhibition of LOX-1 prevents inflammation and photoreceptor cell death in retinal degeneration

    DOI: 10.1016/j.intimp.2020.106190

    PMID: 31945611

    Sample: Cell culture supernatant
  58. Journal of biochemical and molecular toxicology (2019) IF: 3.606
    Gastrodin alleviates Tourette syndrome via Nrf-2/HO-1/HMGB1/NF-кB pathway

    DOI: 10.1002/jbt.22389

    PMID: 31468582

    Sample: Tissue homogenate
  59. International immunopharmacology (2019) IF: 3.943
    Regulation of CD39 expression in ATP-P2Y2R-mediated alcoholic liver steatosis and inflammation

    DOI: 10.1016/j.intimp.2019.105915

    PMID: 31639617

    Sample: Serum,Cell culture supernatant
  60. American Journal of Translational Research (2019) IF: 3.375
    Xiaoyaosan prevents atherosclerotic vulnerable plaque formation through heat shock protein/glucocorticoid receptor axis-mediated mechanism

    PMID: 31632527

    Sample: Serum
  61. Investigative ophthalmology & visual science (2018) IF: 3.27
    Aspergillus fumigatus Increased PAR-2 Expression and Elevated Proinflammatory Cytokines Expression Through the Pathway of PAR-2/ERK1/2 in Cornea

    DOI: 10.1167/iovs.17-21887

    PMID: 29332129

    Sample: Tissue homogenate
  62. International immunopharmacology (2018) IF: 3.118
    Interaction of mannose binding lectin and other pattern recognition receptors in human corneal epithelial cells during Aspergillus fumigatus infection

    DOI: 10.1016/j.intimp.2018.08.003

    PMID: 30096599

    Sample: Tissue homogenate
  63. Bioorganic chemistry (2019) IF: 3.929
    Assessment of novel azaanthraquinone derivatives as potent multi-target inhibitors of inflammation and amyloid-β aggregation in Alzheimer's disease

    DOI: 10.1016/j.bioorg.2018.10.073

    PMID: 30448726

    Sample: Cell culture medium
  64. American journal of translational research (2019) IF: 3.061
    Vascular endothelial Cdc42 deficiency delays skin wound-healing processes by increasing IL-1β and TNF-α expression

    PMID: 30787984

    Sample: Tissue homogenate
  65. Fish & shellfish immunology (2019) IF: 3.185
    Anti-inflammatory effect of a novel synthetic compound 1-((4-fluorophenyl) thio) isoquinoline in RAW264. 7 macrophages and a zebrafish model

    DOI: 10.1016/j.fsi.2019.01.030

    PMID: 30685466

    Sample: Cell culture supernatant
  66. Frontiers in endocrinology (2018) IF: 3.519
    Verapamil ameliorates hepatic metaflammation by inhibiting thioredoxin-interacting protein/NLRP3 inflammasome activation

    DOI: 10.3389/fendo.2018.00640

    PMID: 30429827

    Sample: Serum
  67. Toxicology and applied pharmacology (2019) IF: 3.616
    SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress

    DOI: 10.1016/j.taap.2018.10.013

    PMID: 30336174

    Sample: Serum,Tissue homogenate
  68. Journal of Functional Foods (2019) IF: 3.47
    The protective effects of Chinese yam polysaccharide against obesity-induced insulin resistance

    DOI: 10.1016/j.jff.2019.02.023

    Sample: Serum
  69. International journal of molecular sciences (2019) IF: 3.687
    Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways

    DOI: 10.3390/ijms20051103

    PMID: 30836660

    Sample: Serum
  70. Colloids and Surfaces B: Biointerfaces (2019) IF: 3.973
    CD47-targeted bismuth selenide nanoparticles actualize improved photothermal therapy by increasing macrophage phagocytosis of cancer cells

    DOI: 10.1016/j.colsurfb.2019.110546

    PMID: 31606701

    Sample: Plasma
  71. Molecules (2019) IF: 3.06
    Design, Synthesis and Investigation of the Potential Anti-inflammatory Activity of 7-O-Amide Hesperetin Derivatives

    DOI: 10.3390/molecules24203663

    PMID: 31614601

    Sample: Cell culture supernatant
  72. Biomedicine & Pharmacotherapy (2018) IF: 3.457
    Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity.

    DOI: 10.1016/j.biopha.2018.07.081

    PMID: 30119204

    Sample: Serum
  73. Front Pharmacol (2017) IF: 3.831
    Quercetin Inhibits LPS-Induced Inflammation and ox-LDL-Induced Lipid Deposition.

    DOI: 10.3389/fphar.2017.00040

    PMID: 28217098

    Sample: Cell
  74. Biomedicine & Pharmacotherapy (2018) IF: 3.457
    The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice.

    DOI: 10.1016/j.biopha.2018.07.063

    PMID: 30119194

    Sample: Serum,Tissue homogenate
  75. Neuroscience (2017) IF: 3.277
    Blocking The CD38/cADPR Pathway Plays A Double-edged Role In LPS Stimulated Microglia.

    DOI: 10.1016/j.neuroscience.2017.08.010

    PMID: 28807785

    Sample: Cell culture supernatant
  76. Acta Pharmacologica Sinica (2017) IF: 3.223
    Molecular Mechanisms Of the Analgesic Action Of Wu-tou Decoction On Neuropathic Pain In Mice Revealed Using Microarray And Network Analysis.

    DOI: 10.1038/aps.2017.110

    PMID: 28816231

    Sample: Tissue homogenate
  77. Acta Pharmacologica Sinica (2017) IF: 3.223
    Osthole Prevents Acetaminophen-Induced Liver Injury In Mice.

    DOI: 10.1038/aps.2017.129

    PMID: 29022574

    Sample: Tissue homogenate
  78. International Journal of Chronic Obstructive Pulmonary Disease (2017) IF: 3.157
    Repression Of Toll-Like Receptor-4 By microRNA-149-3p Is Associated With Smoking-Related COPD.

    DOI: 10.2147/COPD.S128031

    PMID: 28260877

    Sample: Cell culture supernatant
  79. Innate Immunity (2021) IF: 2.68
    Chrysosplenol D protects mice against LPS-induced acute lung injury by inhibiting oxidative stress, inflammation, and apoptosis via TLR4-MAPKs/NF-κB signaling pathways

    DOI: 10.1177/17534259211051069

    PMID: 34806444

    Sample: Bronchoalveolar Lavage Fluid
  80. Plants (2020) IF: 2.762
    Phytochemical, Cytotoxicity, Antioxidant and Anti-Inflammatory Effects of Psilocybe Natalensis Magic Mushroom

    DOI: 10.3390/plants9091127

    PMID: 32878164

    Sample: Cell culture supernatant
  81. Journal of Neuroscience Methods (2020) IF: 2.214
    Frequent exposure to varied home cage sizes alters pain sensitivity and some key inflammation-related biomarkers

    DOI: 10.1016/j.jneumeth.2020.108890

    PMID: 32768413

    Sample: Tissue homogenate
  82. Bioscience Reports (2020) IF: 2.942
    Atractylon treatment prevents sleep-disordered breathing-induced cognitive dysfunction by suppression of chronic intermittent hypoxia-induced M1 microglial activation

    DOI: 10.1042/BSR20192800

    PMID: 32490526

    Sample: Cell culture supernatant
  83. Microbial Pathogenesis (2020) IF: 2.914
    Exposure time determines the protective effect of Trichinella spiralis on experimental colitis

    DOI: 10.1016/j.micpath.2020.104263

    PMID: 32442663

    Sample: Serum
  84. Cytokine (2020) IF: 2.952
    6-Gingerol attenuates macrophages pyroptosis via the inhibition of MAPK signaling pathways and predicts a good prognosis in sepsis

    DOI: 10.1016/j.cyto.2019.154854

    PMID: 31539844

    Sample: Cell culture supernatant
  85. Molecular Medicine Reports (2020) IF: 2.1
    Coenzyme Q10 alleviates sevoflurane-induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons

    DOI: 10.3892/mmr.2020.11131

    PMID: 32377738

    Sample: Tissue homogenate
  86. Experimental Physiology (2020) IF: 2.431
    Knockout of MD1 contributes to sympathetic hyperactivity and exacerbates ventricular arrhythmias following heart failure with preserved ejection fraction via NLRP3 inflammasome activation

    DOI: 10.1113/EP088390

    PMID: 32240565

    Sample: Tissue homogenate
  87. PeerJ (2020) IF: 2.379
    The immunostimulatory activity of polysaccharides from Glycyrrhiza uralensis

    DOI: 10.7717/peerj.8294

    PMID: 32030319

    Sample: Tissue homogenate
  88. Molecular medicine reports (2018) IF: 2.1
    Dioscin prevents LPS-induced acute lung injury through inhibiting the TLR4/MyD88 signaling pathway via upregulation of HSP70

    DOI: 10.3892/mmr.2018.8667

    PMID: 29512786

    Sample: Serum,Tissue homogenate
  89. Inflammation (2018) IF: 2.884
    miR-590-3p Attenuates Acute Kidney Injury by Inhibiting Tumor Necrosis Factor Receptor-Associated Factor 6 in Septic Mice

    DOI: 10.1007/s10753-018-0921-5

    PMID: 30392071

    Sample: Serum
  90. Molecular diversity (2019) IF: 2.229
    Hybrids of oxoisoaporphine-tetrahydroisoquinoline: novel multi target inhibitors of infammation and amyloid-β aggregation in Alzheimer's disease

    DOI: 10.1007/s11030-018-9905-5

    PMID: 30603938

    Sample: Cell culture medium
  91. Journal of the Science of Food and Agriculture (2019) IF: 2.379
    Effect and mechanism of citral against methicillin-resistant Staphylococcus aureus in vivo

    DOI: 10.1002/jsfa.9677

    PMID: 30891759

    Sample: Serum
  92. Journal of cellular biochemistry (2019) IF: 2.959
    Attractylone Attenuates Sepsis-Associated Encephalopathy and Cognitive Dysfunction by Inhibiting Microglial Activation and Neuroinflammation

    DOI: 10.1002/jcb.27983

    PMID: 30672013

    Sample: Cell culture supernatant,Tissue homogenate
  93. Inflammation (2019) IF: 2.884
    Sinomenine Attenuates Cartilage Degeneration by Regulating miR-223-3p/NLRP3 Inflammasome Signaling

    DOI: 10.1007/s10753-019-00986-3

    PMID: 30847744

    Sample: Serum,Cell culture supernatant
  94. Molecular and Cellular Biochemistry (2018) IF: 2.561
    Propofol specifically suppresses IL-1β secretion but increases bacterial survival in Staphylococcus aureus-infected RAW264. 7 cells.

    DOI: 10.1007/s11010-018-3348-2

    PMID: 29667111

    Sample: cell
  95. Metabolic Brain Disease IF: 2.441
    Gentiopicroside abrogates lipopolysaccharide-induced depressive-like behavior in mice through tryptophan-degrading pathway.

    DOI: 10.1007/s11011-018-0246-y

    PMID: 29948656

    Sample: Plasma
  96. European Journal of Pharmacology (2016) IF: 2.896
    Liraglutide Attenuates Lipopolysaccharide-Induced Acute Lung Injury In Mice.

    DOI: 10.1016/j.ejphar.2016.10.016

    PMID: 27756605

    Sample: Bronchoalveolar Lavage Fluid
  97. Molecules (2017) IF: 2.861
    Capparis Spinosa Fruit Ethanol Extracts Exert Different Effects On The Maturation Of Dendritic Cells.

    DOI: 10.3390/molecules22010097

    PMID: 28067853

    Sample: Cell culture supernatant
  98. Placenta (2015) IF: 2.759
    The Effect Of Maternal Obesity On The Expression And Functionality Of Placental P-Glycoprotein: Implications In The Individualized Transplacental Digoxin Treatment For Fetal Heart Failure.

    DOI: 10.1016/j.placenta.2015.08.007

    PMID: 26311557

    Sample: Plasma
  99. Biochemical & Biophysical Research Communications (2015) IF: 2.466
    Ghrelin Ameliorates Intestinal Barrier Dysfunction In Experimental Colitis By Inhibiting The Activation Of Nuclear Factor-Kappa B.

    DOI: 10.1016/j.bbrc.2015.01.083

    PMID: 25634696

    Sample: Tissue homogenate
  100. Food Science & Nutrition (2020) IF: 1.797
    Subcutaneous administration of casein attenuates atherosclerotic progression in male apoE -/- mice fed with high-fat diet

    DOI: 10.1002/fsn3.1638

    PMID: 32724618

    Sample: Plasma
  101. Experimental and Therapeutic Medicine (2020) IF: 1.785
    Clostridium butyricum protects intestinal barrier function via upregulation of tight junction proteins and activation of the Akt/mTOR signaling pathway in a mouse model of dextran sodium sulfate-induced colitis

    DOI: 10.3892/etm.2020.9138

    PMID: 32934675

    Sample: Serum
  102. Bioscience, Biotechnology, and Biochemistry (2020) IF: 1.516
    LncRNA TUG1 reverses LPS-induced cell apoptosis and inflammation of macrophage via targeting miR-221-3p/SPRED2 axis

    DOI: 10.1080/09168451.2020.1806704

    PMID: 32841583

    Sample: Tissue homogenate
  103. International journal of ophthalmology (2019) IF: 1.33
    Expression and role of calcitonin gene-related peptide in mouse Aspergillus fumigatus keratitis

    DOI: 10.18240/ijo.2019.05.01

    PMID: 31131225

    Sample: Cell culture supernatant
  104. Canadian journal of physiology and pharmacology (2019) IF: 1.946
    Role of Brd4 in the production of inflammatory cytokines in mouse macrophages treated with titanium particles

    DOI: 10.1139/cjpp-2019-0142

    PMID: 31330113

    Sample: Cell culture supernatant
  105. Neuroreport (2018) IF: 1.394
    Gentiopicroside protects neurons from astrocyte-mediated inflammatory injuries by inhibition of nuclear factor-κB and mitogen-activated protein kinase signaling pathways

    DOI: 10.1097/WNR.0000000000001082

    PMID: 29958245

    Sample: Cell culture supernatant
  106. Experimental and therapeutic medicine (2018) IF: 1.41
    miR-148a inhibits pro-inflammatory cytokines released by intervertebral disc cells by regulating the p38/MAPK pathway

    DOI: 10.3892/etm.2018.6516

    PMID: 30186499

    Sample: Cell culture supernatant
  107. Cellular & molecular biology letters (2019) IF: 1.291
    Tetrahydroxy stilbene glucoside alleviates palmitic acid-induced inflammation and apoptosis in cardiomyocytes by regulating miR-129-3p/Smad3 signaling

    DOI: 10.1186/s11658-018-0125-x

    PMID: 30820195

    Sample: Cell culture supernatant
  108. Journal of biochemical and molecular toxicology (2019) IF: 1.837
    Gastrodin attenuates neuroinflammation in DOI-induce Tourette syndrome in rats

    DOI: 10.1002/jbt.22302

    PMID: 30790395

    Sample: Serum,Tissue homogenate
  109. Cellular & molecular biology letters (2019) IF: 1.291
    Honokiol alleviates sepsis-induced acute kidney injury in mice by targeting the miR-218-5p/heme oxygenase-1 signaling pathway

    DOI: 10.1186/s11658-019-0142-4

    PMID: 30833971

    Sample: Serum
  110. BMC Pharmacology and Toxicology (2020) IF: 1.771
    Impact of Lesinurad and allopurinol on experimental Hyperuricemia in mice: biochemical, molecular and Immunohistochemical study

    DOI: 10.1186/s40360-020-0386-7

    PMID: 32041665

    Sample: Serum
  111. Oncology Letters (2018) IF: 1.39
    The Association Between Inflammation, The Microbiome and Urethane-induced Pulmonary Adenocarcinoma.

    DOI: 10.3892/ol.2018.8167

    PMID: 29725395

  112. Molecular Medicine Reports (2018) IF: 1.692
    Oral supplementation with ursolic acid ameliorates sepsis-induced acute kidney injury in a mouse model by inhibiting oxidative stress and inflammatory responses.

    DOI: 10.3892/mmr.2018.8767

    PMID: 29568928

  113. Experimental and Therapeutic Medicine (2017) IF: 1.261
    Effects Of Sepsis On The Metabolism Of Sphingomyelin And Cholesterol In Mice With Liver Dysfunction.

    DOI: 10.3892/etm.2017.5226

    PMID: 29285103

    Sample: Plasma
  114. Journal of Oleo Science (2015) IF: 1.076
    A Comparative Study Of The Effects Upon LPS Induced Macrophage RAW264.7 Inflammation In Vitro Of The Lipids Of Hippocampus Trimaculatus Leach.

    DOI: 10.5650/jos.ess15190

    PMID: 26582156

    Sample: Cell culture supernatant
  115. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research (2020)
    Methamphetamine induced neuroinflammation in mouse brain and microglial cell line BV2: Roles of the TLR4/TRIF/Peli1 signaling axis

    DOI: 10.1016/j.toxlet.2020.07.028

    PMID: 32768653

    Sample: Cell culture supernatant,Tissue homogenate
  116. Advances in Pharmacological and Pharmaceutical Sciences (2020)
    Antihypernociceptive, Anxiolytic, and Antidepressant Properties of Aqueous and Ethanol Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Mice

    DOI: 10.1155/2020/8886894

    PMID: 33015629

    Sample: Serum,Tissue homogenate
  117. The FASEB Journal (2020)
    CaMK4-dependent phosphorylation of Akt/mTOR underlies Th17 excessive activation in experimental autoimmune prostatitis

    DOI: 10.1096/fj.201902910RRR

    PMID: 32862457

    Sample: Cell culture supernatant,Tissue homogenate
  118. Plant Archives (2020)
    Sample: Serum
  119. SSRN (2020)
    Salidroside Attenuates Liver Injury in Diabetes Mice

    DOI: 10.2139/ssrn.3546025

    Sample: Serum,Cell culture supernatant,Tissue homogenate
  120. Journal of Cellular and Molecular Medicine (2020)
    Polysaccharides from Dicliptera chinensis ameliorate liver disturbance by regulating TLR-4/NF-κB and AMPK/Nrf2 signalling pathways

    DOI: 10.1111/jcmm.15286

    PMID: 32337831

    Sample: Serum,Tissue homogenate
  121. Open access Macedonian journal of medical sciences (2019)
    Neuroprotective Activity of Evolvulus alsinoides & Centella asiatica Ethanolic Extracts in Scopolamine-Induced Amnesia in Swiss Albino Mice

    DOI: 10.3889/oamjms.2019.247

    PMID: 31049081

    Sample: Tissue homogenate
  122. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease (2019)
    Nod1-mediated lipolysis promotes diacylglycerol accumulation and successive inflammation via PKC未-IRAK axis in adipocytes

    DOI: 10.1016/j.bbadis.2018.10.036

    PMID: 30391544

    Sample: Cell culture supernatant
  123. Naunyn-Schmiedeberg's archives of pharmacology (2019)
    Antihypernociceptive and neuroprotective effects of Combretin A and Combretin B on streptozotocin-induced diabetic neuropathy in mice.

    DOI: 10.1007/s00210-019-01626-1

    PMID: 30759263

    Sample: Serum,Spinal cord
  124. BMC Complementary Medicine and Therapies (2020)
    Shen-ling-bai-zhu-san ameliorates inflammation and lung injury by increasing the gut microbiota in the murine model of Streptococcus pneumonia-induced pneumonia

    DOI: 10.1186/s12906-020-02958-9

    PMID: 32460745

    Sample: Tissue homogenate
  125. Preprints (2019)
    Ameliorative Effects of Lesinurad (Zurampic) on Experimental Hyperuricemia, Biochemical, Molecular and Immunohistochemical Study

    DOI: 10.21203/rs.2.17096/v1

    Sample: Serum
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