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Mouse IL-6(Interleukin 6) ELISA Kit

Citations(135)Uniprot : P08505

  • Cat.No.:E-EL-M0044

  • Reactivity: Mouse
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Manual MSDS

To Purchase E-EL-M0044

Size:
  • 96T
  • 48T
  • 24T
  • 96T*5
  • 96T*10
Price: $495
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Product Details

Properties

Assay type Sandwich-ELISA
Format 96T/48T
Assay time 3.5h
Detection range 31.25-2000 pg/mL
Sensitivity 18.75 pg/mL
Sample type &Sample volume serum, plasma and other biological fluids; 100μL
Specificity This kit recognizes Mouse IL-6 in samples. No significant cross-reactivity or interference between Mouse IL-6 and analogues was observed.
Reproducibility Both intra-CV and inter-CV are < 10%.
Application This ELISA kit applies to the in vitro quantitative determination of Mouse IL-6 concentrations in serum, plasma and other biological fluids.

Test Principle

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse IL-6. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Mouse IL-6 and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse IL-6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of Mouse IL-6. You can calculate the concentration of Mouse IL-6 in the samples by comparing the OD of the samples to the standard curve.

Kit components & Storage

An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the components separately according to the following conditions once the kit is received.
ItemSpecificationsStorage
Micro ELISA Plate(Dismountable) 96T: 8 wells ×12 strips
48T: 8 wells ×6 strips 		-20℃, 6 months
Reference Standard 96T: 2 vials
48T: 1 vial
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL 		-20℃(Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL
HRP Conjugate Diluent 1 vial, 14 mL
Concentrated Wash Buffer (25×) 1 vial, 30 mL
Substrate Reagent 1 vial, 10 mL 2-8℃(Protect from light)
Stop Solution 1 vial, 10 mL 2-8°C
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Technical Data

Precision

Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Mouse IL-6 were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Mouse IL-6 were tested on 3 different plates, 20 replicates in each plate.

  Intra-assay Precision Inter-assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (pg/mL) 99.40 174.50 952.80 105.30 162.70 1040.70
Standard deviation 6.40 7.70 50.50 6.50 8.10 38.50
CV (%) 6.44 4.41 5.30 6.17 4.98 3.70

Recovery

The recovery of Mouse IL-6 spiked at three different levels in samples throughout the range of the assay was evaluated in various matrices.

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 86-100 93
EDTA plasma (n=8) 88-101 94
Cell culture media (n=8) 89-104 95

Linearity

Samples were spiked with high concentrations of Mouse IL-6 and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

Target Information

Database LinksSwissProt: P08505
SynonymsIL6, BSF2, HGF, HSF, IFNB2, CDF
Research AreaCancer,Neuroscience

Assay Procedures

elisa assay procedure 1

1. Add 100μL standard or sample to the wells. Incubate for 90 min at 37°C
elisa assay procedure 2

2. Discard the liquid, immediately add 100μL Biotinylated Detection Ab working solution to each well. Incubate for 60 min at 37°C
elisa assay procedure 3

3. Aspirate and wash the plate for 3 times
elisa assay procedure 4

4. Add 100μL HRP conjugate working solution. Incubate for 30 min at 37°C. Aspirate and wash the plate for 5 times
elisa assay procedure 5

5. Add 90μL Substrate Reagent. Incubate for 15 min at 37°C
elisa assay procedure 6

6. Add 50μL Stop Solution
elisa assay procedure 7

7. Read the plate at 450nm immediately. Calculation of the results

Citations

From now on, if you have published a paper by using any of our products since 1/1/2019, fill out the “Elabscience Publication Reward Application Form”carefully and send it to orders@elabscience.com, we will get back to you with the reward after we confirm it ASAP!

View more details about our Publication Reward >>

  1. Advanced functional materials (2020) IF: 16.836
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    DOI: 10.1002/adfm.202001771

    PMID: 99999999

    		 Sample: Serum
  2. Sci Transl Med (2020) IF: 16.304
    Nuclear Receptor PXR Targets AKR1B7 to Protect Mitochondrial Metabolism and Renal Function in AKI

    DOI: 10.1126/scitranslmed.aay7591

    PMID: 32404507

    		 Sample: Serum
  3. Advanced Functional Materials (2019) IF: 16.836
    NIR/ROS-Responsive Black Phosphorus QD Vesicles as Immunoadjuvant Carrier for Specific Cancer Photodynamic Immunotherapy

    DOI: 10.1002/adfm.201905758

    PMID: 99999999

    		 Sample: Serum
  4. Molecular Cell (2017) IF: 14.714
    Celastrol-Induced Nur77 Interaction With TRAF2 Alleviates Inflammation By Promoting Mitochondrial Ubiquitination And Autophagy.

    DOI: 10.1016/j.molcel.2017.03.008

    PMID: 28388439

    		 Sample: Serum
  5. NANO LETTERS (2019) IF: 11.238
    NanoRNP Overcomes Tumor Heterogeneity in Cancer Treatment

    DOI: 10.1021/acs.nanolett.9b02501

    PMID: 31593471

    		 Sample: Serum
  6. Chem. Sci. (2020) IF: 9.346
    A tumor acidity activatable and Ca2+-assisted immuno-nanoagent enhances breast cancer therapy and suppresses cancer recurrence

    DOI: 10.1039/d0sc00293c

    PMID: 99999999

    		 Sample: Serum
  7. Bone research (2018) IF: 9.326
    Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines.

    DOI: 10.1038/s41413-018-0012-0

    PMID: 29619269
  8. Theranostics (2020) IF: 8.579
    Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy

    DOI: 10.7150/thno.45028

    PMID: 32685027

    		 Sample: Serum
  9. Free Radical Biology and Medicine (2020) IF: 6.17
    Dry eye induced by exposure to cigarette smoke pollution: An in vivo and in vitro study

    DOI: 10.1016/j.freeradbiomed.2020.04.007

    PMID: 32320747

    		 Sample: Cell lysate,Cell culture supernatant
  10. Free Radical Biology and Medicine (2019) IF: 6.17
    Oral administration of 3,3'-diselenodipropionic acid prevents thoracic radiation induced pneumonitis in mice by suppressing NF-kB/IL-17/G-CSF/neutrophil axis

    DOI: 10.1016/j.freeradbiomed.2019.09.009

    PMID: 31521664

    		 Sample: Bronchoalveolar Lavage Fluid,Tissue homogenate
  11. Acta Biomaterialia (2020) IF: 6.638
    Near-infrared/pH dual-responsive nanocomplexes for targeted imaging and chemo/gene/photothermal tri-therapies of non-small cell lung cancer

    DOI: https://doi.org/10.1016/j.actbio.2020.03.004

    PMID: 32151700

    		 Sample: Whole Blood
  12. Analytical chemistry (2018) IF: 6.042
    A Redox-Responsive Self-Assembled Nanoprobe for Photoacoustic Inflammation Imaging to Assess Atherosclerotic Plaque Vulnerability

    DOI: 10.1021/acs.analchem.8b04912

    PMID: 30497260

    		 Sample: Cell culture supernatant
  13. International Journal of Biological Macromolecules (2020) IF: 5.162
    A novel polysaccharide from Acorus tatarinowii protects against LPS-induced neuroinflammation and neurotoxicity by inhibiting TLR4-mediated MyD88/NF-κB and PI3K/Akt signaling pathways

    DOI: 10.1016/j.ijbiomac.2020.06.266

    PMID: 32621930

    		 Sample: Cell culture supernatant
  14. Oxidative Medicine and Cellular Longevity (2020) IF: 5.076
    The Inhibition of P-Selectin Reduced Severe Acute Lung Injury in Immunocompromised Mice

    DOI: 10.1155/2020/8430465

    PMID: 32377309

    		 Sample: Serum
  15. Oxidative Medicine and Cellular Longevity (2019) IF: 5.076
    Maggot Extracts Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis via the Activation of Nrf2

    DOI: 10.1155/2019/4703253

    PMID: 31827675

    		 Sample: Serum
  16. Oxidative medicine and cellular longevity (2019) IF: 5.076
    Targeting IL-17A Improves the Dysmotility of the Small Intestine and Alleviates the Injury of the Interstitial Cells of Cajal during Sepsis

    DOI: 10.1155/2019/1475729

    PMID: 31531179

    		 Sample: Tissue homogenate
  17. Frontiers in immunology (2019) IF: 5.085
    Intranasal MMI-0100 Attenuates Aβ 1-42- and LPS-Induced Neuroinflammation and Memory Impairments via the MK2 Signaling Pathway

    DOI: 10.3389/fimmu.2019.02707

    PMID: 31849936

    		 Sample: Tissue homogenate
  18. Cellular Physiology and Biochemistry (2018) IF: 5.5
    The Effects of Angelica Sinensis Polysaccharide on Tumor Growth and Iron Metabolism by Regulating Hepcidin in Tumor-Bearing Mice.

    DOI: 10.1159/000490185

    PMID: 29843136

    		 Sample: Serum
  19. Oncotarget (2017) IF: 5.168
    Regulatory role of NKG2D+ NK cells in intestinal lamina propria by secreting double-edged Th1 cytokines in ulcerative colitis.

    DOI: 10.18632/oncotarget.22132

    PMID: 29228739

    		 Sample: Tissue homogenate
  20. Oncotarget (2017) IF: 5.168
    Glioblastoma Progression Is Assisted By Induction Of Immunosuppressive Function Of Pericytes Through Interaction With Tumor Cells.

    DOI: 10.18632/oncotarget.19804

    PMID: 28978142

    		 Sample: Cell culture supernatant
  21. Food & Function (2020) IF: 4.171
    Flaxseed oligosaccharides alleviate DSS-induced colitis through modulation of gut microbiota and repair of the intestinal barrier in mice

    DOI: 10.1039/d0fo01105c

    PMID: 32856645

    		 Sample: Serum,Tissue homogenate
  22. Journal of Cellular and Molecular Medicine (2020) IF: 4.486
    Defibrotide inhibits donor leucocyte-endothelial interactions and protects against acute graft-versus-host disease

    DOI: 10.1111/jcmm.15434

    PMID: 32519822

    		 Sample: Plasma
  23. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020) IF: 4.192
    Novel Biomedical Functions of Surfactin A from Bacillus subtilis in Wound Healing Promotion and Scar Inhibition

    DOI: 10.1021/acs.jafc.0c01658

    PMID: 99999999

    		 Sample: Cell culture supernatant
  24. Neuropharmacology (2020) IF: 4.431
    Seizure-induced neuroinflammation contributes to ectopic neurogenesis and aggressive behavior in pilocarpine-induced status epilepticus mice

    DOI: 10.1016/j.neuropharm.2020.108044

    PMID: 32179291

    		 Sample: Cell lysate
  25. Nutrients (2020) IF: 4.546
    Chinese Propolis Prevents Obesity and Metabolism Syndromes Induced by a High Fat Diet and Accompanied by an Altered Gut Microbiota Structure in Mice

    DOI: 10.3390/nu12040959

    PMID: 32235581

    		 Sample: Serum
  26. Biomedicine & Pharmacotherapy (2020) IF: 4.545
    MG-132 attenuates cardiac deterioration of viral myocarditis via AMPK pathway

    DOI: 10.1016/j.biopha.2020.110091

    PMID: 32278272

    		 Sample: Plasma
  27. Journal of agricultural and food chemistry (2020) IF: 4.192
    Novel Biomedical Functions of Surfactin A from Bacillus subtilis in Wound Healing Promotion and Scar Inhibition

    DOI: 10.1021/acs.jafc.0c01658

    PMID: 32412748

    		 Sample: Cell culture supernatant
  28. Journal of Agricultural and Food Chemistry (2020) IF: 4.192
    Modulation of Gut Microbiota by Fucoxanthin During Alleviation of Obesity in High-Fat Diet-Fed Mice

    DOI: 10.1021/acs.jafc.0c01467

    PMID: 32309947

    		 Sample: Serum,Tissue homogenate
  29. Microbial Cell Factories (2020) IF: 4.187
    A probiotic treatment increases the immune response induced by the nasal delivery of spore-adsorbed TTFC

    DOI: 10.1186/s12934-020-01308-1

    PMID: 32075660

    		 Sample: Cell culture supernatant
  30. Nutrients (2020) IF: 4.546
    Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice through Modulating Immune Balance and Skin Barrier Function

    DOI: 10.3390/nu12010249

    PMID: 31963703

    		 Sample: Serum,Cell culture supernatant
  31. Food & Function (2020) IF: 4.171
    Propacin, a coumarinolignoid isolated from durian, inhibits the lipopolysaccharide-induced inflammatory response in macrophages through the MAPK and NF-κB pathways

    DOI: 10.1039/c9fo02202c

    PMID: 31859327

    		 Sample: Cell culture supernatant
  32. Nutrients (2020) IF: 4.546
    Bifidobacteria-Fermented Red Ginseng and Its Constituents Ginsenoside Rd and Protopanaxatriol Alleviate Anxiety/Depression in Mice by the Amelioration of Gut Dysbiosis

    DOI: 10.3390/nu12040901

    PMID: 32224881

    		 Sample: Tissue homogenate
  33. Biomedicine & Pharmacotherapy (2019) IF: 4.545
    Inhibition of HDAC6 attenuates LPS-induced inflammation in macrophages by regulating oxidative stress and suppressing the TLR4-MAPK/NF-κB pathways

    DOI: 10.1016/j.biopha.2019.109166

    PMID: 31255993

    		 Sample: Cell culture supernatant
  34. Ecotoxicology and Environmental Safety (2019) IF: 4.872
    Inflammatory kidney injury in trichloroethylene hypersensitivity syndrome mice: Possible role of C3a receptor in the accumulation of Th17 phenotype

    DOI: 10.1016/j.ecoenv.2019.109772

    PMID: 31614297

    		 Sample: Serum
  35. International journal of molecular sciences (2019) IF: 4.556
    Resveratrol Plays a Protective Role against Premature Ovarian Failure and Prompts Female Germline Stem Cell Survival

    DOI: 10.3390/ijms20143605

    PMID: 31340581

    		 Sample: Serum,Cell culture supernatant
  36. ACS chemical neuroscience (2019) IF: 4.486
    Liproxstatin-1 Attenuates Morphine Tolerance through Inhibiting Spinal Ferroptosis-like Cell Death

    DOI: 10.1021/acschemneuro.9b00539

    PMID: 31682397

    		 Sample: Tissue homogenate
  37. Frontiers in microbiology (2018) IF: 4.019
    The influence of Acanthamoeba-Legionella interaction in the virulence of two different Legionella species.

    DOI: 10.3389/fmicb.2018.02962

    PMID: 30568639

    		 Sample: Cell culture supernatant
  38. Neurobiology of aging (2019) IF: 4.454
    CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits

    DOI: 10.1016/j.neurobiolaging.2018.11.023

    PMID: 30594047

    		 Sample: Tissue homogenate,Cell culture medium
  39. Oxidative Medicine And Cellular Longevity (2016) IF: 4.593
    Hydrogen Sulfide Mitigates Kidney Injury In High Fat Diet-Induced Obese Mice.

    DOI: 10.1155/2016/2715718

    PMID: 27413418

    		 Sample: Plasma
  40. Scientific Reports (2017) IF: 4.259
    Glycyrrhiza Uralensis Water Extract Enhances Dendritic Cell Maturation And Antitumor Efficacy Of HPV Dendritic Cell-Based Vaccine.

    DOI: 10.1038/srep43796

    PMID: 28272545

    		 Sample: Cell culture supernatant
  41. Carbohydrate Polymers (2016) IF: 4.811
    Structural Analysis And Immunoregulation Activity Comparison Of Five Polysaccharides From Angelica Sinensis.

    DOI: 10.1016/j.carbpol.2015.12.050

    PMID: 26876821

    		 Sample: Cell culture supernatant
  42. International Journal of Nanomedicine (2016) IF: 4.3
    Effects Of Silver Nanoparticles In Combination With Antibiotics On The Resistant Bacteria Acinetobacter Baumannii.

    DOI: 10.2147/IJN.S104166

    PMID: 27574420

    		 Sample: Plasma
  43. Frontiers in Aging Neuroscience (2015) IF: 4.504
    PGC-1α Silencing Compounds The Perturbation Of Mitochondrial Function Caused By Mutant SOD1 In Skeletal Muscle Of ALS Mouse Model.

    DOI: 10.3389/fnagi.2015.00204

    PMID: 26539112

    		 Sample: Serum
  44. Life Sciences (2020) IF: 3.647
    Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways

    DOI: 10.1016/j.lfs.2020.118546

    PMID: 33035580

    		 Sample: Serum
  45. Life Sciences (2020) IF: 3.647
    Fenugreek attenuates obesity-induced inflammation and improves insulin resistance through downregulation of iRhom2/TACE

    DOI: 10.1016/j.lfs.2020.118222

    PMID: 32768577

    		 Sample: Serum
  46. International Immunopharmacology (2020) IF: 3.943
    miR-129-5p alleviates LPS-induced acute kidney injury via targeting HMGB1/TLRs/NF-kappaB pathway

    DOI: 10.1016/j.intimp.2020.107016

    PMID: 33039954

    		 Sample: Serum
  47. International Immunopharmacology (2020) IF: 3.943
    COX-2-PGE 2 signaling pathway contributes to hippocampal neuronal injury and cognitive impairment in PTZ-kindled epilepsy mice

    DOI: 10.1016/j.intimp.2020.106801

    PMID: 32702600

    		 Sample: Tissue homogenate
  48. European Review for Medical and Pharmacological Sciences (2020) IF: 3.024
    miR-181-5p protects mice from sepsis via repressing HMGB1 in an experimental model

    DOI: 10.26355/eurrev_202009_23063

    PMID: 33015817

    		 Sample: Serum
  49. European Journal of Pharmacology (2020) IF: 3.263
    Glucagon-like peptide-1 cleavage product GLP-1(9-36) reduces neuroinflammation from stroke via the activation of insulin-like growth factor 1 receptor in astrocytes

    DOI: 10.1016/j.ejphar.2020.173581

    PMID: 32949596

    		 Sample: Cell culture supernatant
  50. Biomolecules & Therapeutics (2020) IF: 3.47
    Antineuroinflammatory Effects of 7,3',4'-Trihydroxyisoflavone in Lipopolysaccharide-Stimulated BV2 Microglial Cells through MAPK and NF-κB Signaling Suppression

    DOI: 10.4062/biomolther.2020.093

    PMID: 32812529

    		 Sample: Cell culture supernatant
  51. American Journal of Translational Research (2020) IF: 3.375
    Overexpression of lncRNA Gm43050 alleviates apoptosis and inflammation response induced by sevoflurane treatment by regulating miR-640/ZFP91

    PMID: 32913509

    		 Sample: Cell culture supernatant
  52. Journal of Drug Targeting (2020) IF: 3.38
    Development, optimisation and evaluation of chitosan nanoparticles of alendronate against Alzheimer's disease in intracerebroventricular streptozotocin model for brain delivery

    DOI: 10.1080/1061186X.2020.1817041

    PMID: 32876502

    		 Sample: Tissue homogenate
  53. Journal of Biochemical and Molecular Toxicology (2020) IF: 3.606
    Protective roles and mechanisms of rosmarinic acid in cyclophosphamide-induced premature ovarian failure

    DOI: 10.1002/jbt.22591

    PMID: 32711407

    		 Sample: Serum
  54. Neurochemical Research (2020) IF: 3.038
    Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage

    DOI: 10.1007/s11064-020-03012-3

    PMID: 32170675

    		 Sample: Tissue homogenate
  55. International Immunopharmacology (2020) IF: 3.943
    Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway

    DOI: 10.1016/j.intimp.2020.106287

    PMID: 32058932

    		 Sample: Tissue homogenate
  56. IUBMB life (2020) IF: 3.244
    Blockade of high mobility group box 1 involved in the protective of curcumin on myocardial injury in diabetes in vivo and in vitro

    DOI: 10.1002/iub.2226

    PMID: 31909882

    		 Sample: Serum
  57. International Immunopharmacology (2020) IF: 3.943
    Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation

    DOI: 10.1016/j.intimp.2019.106181

    PMID: 31926446

    		 Sample: Cell sample,Tissue homogenate
  58. Chemico-Biological Interactions (2020) IF: 3.723
    Pregnane X receptor activation by its natural ligand Ginkgolide-A improves tight junction proteins expression and attenuates bacterial translocation in cirrhosis

    DOI: 10.1016/j.cbi.2019.108891

    PMID: 31697926

    		 Sample: Plasma,Tissue homogenate
  59. Food & Nutrition Research (2020) IF: 3.647
    Camellia cake extracts reduce burn injury through suppressing inflammatory responses and enhancing collagen synthesis

    DOI: 10.29219/fnr.v64.3782

    PMID: 32425739

    		 Sample: Tissue homogenate
  60. Psychopharmacology (2020) IF: 3.13
    The protective effect of Geniposide on diabetic cognitive impairment through BTK/TLR4/NF-κB pathway

    DOI: 10.1007/s00213-019-05379-w

    PMID: 31811349

    		 Sample: Serum
  61. Scientific reports (2020) IF: 3.998
    Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway

    DOI: 10.1038/s41598-020-66789-x

    PMID: 32555320

    		 Sample: Serum
  62. Journal of Functional Foods (2020) IF: 3.701
    Anti-fatigue activity of purified anthocyanins prepared from purple passion fruit (P. edulis Sim) epicarp in mice

    DOI: 10.1016/j.jff.2019.103725

    PMID: 99999999

    		 Sample: Tissue homogenate
  63. Frontiers in Endocrinology (2020) IF: 3.644
    The Protective Effects of Melatonin Against LPS-Induced Septic Myocardial Injury: A Potential Role of AMPK-Mediated Autophagy

    DOI: 10.3389/fendo.2020.00162

    PMID: 32373063

    		 Sample: Serum
  64. European journal of pharmacology (2019) IF: 3.263
    Circular RNA expression profile of liver tissues in an EtOH-induced mouse model of alcoholic hepatitis

    DOI: 10.1016/j.ejphar.2019.172642

    PMID: 31493407

    		 Sample: Serum,Tissue homogenate
  65. International immunopharmacology (2019) IF: 3.943
    Regulation of CD39 expression in ATP-P2Y2R-mediated alcoholic liver steatosis and inflammation

    DOI: 10.1016/j.intimp.2019.105915

    PMID: 31639617

    		 Sample: Serum,Cell culture supernatant
  66. European journal of pharmacology (2019) IF: 3.263
    Pancreastatin inhibitor PSTi8 attenuates hyperinsulinemia induced obesity and inflammation mediated insulin resistance via MAPK/NOX3-JNK pathway

    DOI: 10.1016/j.ejphar.2019.172723

    PMID: 31586632

    		 Sample: Plasma,Cell culture supernatant,Tissue homogenate
  67. American Journal of Translational Research (2019) IF: 3.375
    Xiaoyaosan prevents atherosclerotic vulnerable plaque formation through heat shock protein/glucocorticoid receptor axis-mediated mechanism

    PMID: 31632527

    		 Sample: Serum
  68. AM J PHYSIOL-RENAL (2020) IF: 3.323
    Inhibition of PDE4/PDE4B Improves Renal Function and Ameliorates Inflammation in Cisplatin-Induced Acute Kidney Injury

    DOI: 10.1152/ajprenal.00477.2019

    PMID: 31961716

    		 Sample: Serum
  69. International Immunopharmacology (2020) IF: 3.361
    10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells

    DOI: 10.1016/j.intimp.2020.106501

    PMID: 99999999

    		 Sample: Cell culture supernatant
  70. Frontiers in pharmacology (2018) IF: 3.831
    Emodin attenuates lipopolysaccharide-induced acute liver injury through inhibiting the TLR4 signaling pathway in vitro and in vivo

    DOI: 10.3389/fphar.2018.00962

    PMID: 30186181

    		 Sample: Cell culture supernatant
  71. Bioorganic chemistry (2019) IF: 3.929
    Assessment of novel azaanthraquinone derivatives as potent multi-target inhibitors of inflammation and amyloid-β aggregation in Alzheimer's disease

    DOI: 10.1016/j.bioorg.2018.10.073

    PMID: 30448726

    		 Sample: Cell culture medium
  72. Fish & shellfish immunology (2019) IF: 3.185
    Anti-inflammatory effect of a novel synthetic compound 1-((4-fluorophenyl) thio) isoquinoline in RAW264. 7 macrophages and a zebrafish model

    DOI: 10.1016/j.fsi.2019.01.030

    PMID: 30685466

    		 Sample: Cell culture supernatant
  73. Toxicology and applied pharmacology (2019) IF: 3.616
    SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress

    DOI: 10.1016/j.taap.2018.10.013

    PMID: 30336174

    		 Sample: Serum,Tissue homogenate
  74. Molecules (2018) IF: 3.098
    Nuciferine Inhibits Proinflammatory Cytokines via the PPARs in LPS-Induced RAW264. 7 Cells

    DOI: 10.3390/molecules23102723

    PMID: 30360404

    		 Sample: Cell culture supernatant
  75. International journal of molecular sciences (2019) IF: 3.687
    Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways

    DOI: 10.3390/ijms20051103

    PMID: 30836660

    		 Sample: Serum
  76. Toxicology (2019) IF: 3.265
    4-Methylcoumarin-[5,6–g]-hesperetin attenuates inflammatory responses in alcoholic hepatitis through PPAR-γ activation

    DOI: 10.1016/j.tox.2019.04.004

    PMID: 30951781

    		 Sample: Serum,Cell culture supernatant
  77. Life Sciences (2020) IF: 3.647
    Pretreatment of exosomes derived from hUCMSCs with TNF-α ameliorates acute liver failure by inhibiting the activation of NLRP3 in macrophage

    DOI: 10.1016/j.lfs.2020.117401

    PMID: 32035931

    		 Sample: Whole Blood,Tissue homogenate
  78. Frontiers in Pharmacology (2019) IF: 3.845
    Ameliorative Effects of Suhuang Antitussive Capsule on LPS-Induced Sputum Obstruction in Mice through Promoting HGF Secretion via an Intestinal Endocrine-Dependent Pathway

    DOI: 10.3389/fphar.2019.01422

    PMID: 99999999

    		 Sample: Serum,Tissue homogenate
  79. Molecules (2019) IF: 3.06
    Design, Synthesis and Investigation of the Potential Anti-inflammatory Activity of 7-O-Amide Hesperetin Derivatives

    DOI: 10.3390/molecules24203663

    PMID: 31614601

    		 Sample: Cell culture supernatant
  80. Biomedicine & Pharmacotherapy (2018) IF: 3.457
    The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice.

    DOI: 10.1016/j.biopha.2018.07.063

    PMID: 30119194

    		 Sample: Serum,Tissue homogenate
  81. Neuroscience (2017) IF: 3.277
    Blocking The CD38/cADPR Pathway Plays A Double-edged Role In LPS Stimulated Microglia.

    DOI: 10.1016/j.neuroscience.2017.08.010

    PMID: 28807785

    		 Sample: Cell culture supernatant
  82. Acta Pharmacologica Sinica (2017) IF: 3.223
    Osthole Prevents Acetaminophen-Induced Liver Injury In Mice.

    DOI: 10.1038/aps.2017.129

    PMID: 29022574

    		 Sample: Tissue homogenate
  83. Journal of Neuroscience Methods (2020) IF: 2.214
    Frequent exposure to varied home cage sizes alters pain sensitivity and some key inflammation-related biomarkers

    DOI: 10.1016/j.jneumeth.2020.108890

    PMID: 32768413

    		 Sample: Tissue homogenate
  84. Bioscience Reports (2020) IF: 2.942
    Atractylon treatment prevents sleep-disordered breathing-induced cognitive dysfunction by suppression of chronic intermittent hypoxia-induced M1 microglial activation

    DOI: 10.1042/BSR20192800

    PMID: 32490526

    		 Sample: Cell culture supernatant
  85. Molecular Medicine Reports (2020) IF: 2.1
    Osthole inhibits proliferation of kainic acid-activated BV-2 cells by modulating the Notch signaling pathway

    DOI: 10.3892/mmr.2020.11455

    PMID: 33000274

    		 Sample: Cell culture supernatant
  86. Molecular Medicine Reports (2020) IF: 2.1
    Astaxanthin suppresses lipopolysaccharide-induced myocardial injury by regulating MAPK and PI3K/AKT/mTOR/GSK3β signaling

    DOI: 10.3892/mmr.2020.11443

    PMID: 32945516

    		 Sample: Serum
  87. Brain and behavior (2020) IF: 2.091
    MicroRNA-345-5p regulates depression by targeting suppressor of cytokine signaling 1

    DOI: 10.1002/brb3.1653

    PMID: 32730696

    		 Sample: Cell culture supernatant
  88. Microbial Pathogenesis (2020) IF: 2.914
    Curcumin ameliorates Staphylococcus aureus-induced mastitis injury through attenuating TLR2-mediated NF-κB activation

    DOI: 10.1016/j.micpath.2020.104054

    PMID: 32061917

    		 Sample: Serum
  89. Molecular Medicine Reports (2020) IF: 2.1
    Coenzyme Q10 alleviates sevoflurane-induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons

    DOI: 10.3892/mmr.2020.11131

    PMID: 32377738

    		 Sample: Tissue homogenate
  90. Poultry science (2019) IF: 2.659
    Anti-inflammatory effect of preserved egg with simulated gastrointestinal digestion on LPS-stimulated RAW264.7 cells

    DOI: 10.3382/ps/pez243

    PMID: 31041437

    		 Sample: Cell culture supernatant
  91. Molecular medicine reports (2018) IF: 2.1
    Dioscin prevents LPS-induced acute lung injury through inhibiting the TLR4/MyD88 signaling pathway via upregulation of HSP70

    DOI: 10.3892/mmr.2018.8667

    PMID: 29512786

    		 Sample: Serum,Tissue homogenate
  92. Medicine (2018) IF: 2.028
    Effect of gap junctions on RAW264. 7 macrophages infected with H37Rv

    DOI: 10.1097/MD.0000000000012125

    PMID: 30170447

    		 Sample: Cell culture supernatant
  93. Inflammation (2018) IF: 2.884
    miR-590-3p Attenuates Acute Kidney Injury by Inhibiting Tumor Necrosis Factor Receptor-Associated Factor 6 in Septic Mice

    DOI: 10.1007/s10753-018-0921-5

    PMID: 30392071

    		 Sample: Serum
  94. Bioscience reports (2018) IF: 2.899
    Maggot protein ameliorates dextran sulphate sodium-induced ulcerative colitis in mice

    DOI: 10.1042/BSR20181799

    PMID: 30393231

    		 Sample: Serum
  95. Biochemical and biophysical research communications (2019) IF: 2.559
    Eosinophils attenuate arthritis by inducing M2 macrophage polarization via inhibiting the IkB/P38 MAPK signaling pathway

    DOI: 10.1016/j.bbrc.2018.12.010

    PMID: 30528734

    		 Sample: Tissue homogenate,Cell culture supernatant
  96. Inflammation (2018) IF: 2.884
    Resveratrol Protects Against Renal Damage via Attenuation of Inflammation and Oxidative Stress in High-Fat-Diet-Induced Obese Mice

    DOI: 10.1007/s10753-018-0948-7

    PMID: 30554371

    		 Sample: Tissue homogenate
  97. Bioscience reports (2018) IF: 2.899
    Association of IL-6, IL-8, MMP-13 gene polymorphisms with knee osteoarthritis susceptibility in the Chinese Han population

    DOI: 10.1042/BSR20181346

    PMID: 30635366

    		 Sample: Tissue homogenate
  98. Steroids (2019) IF: 2.523
    Synthesis and Evaluation of Novel D-ring Substituted Steroidal Pyrazolines as Potential Anti-inflammatory Agents

    DOI: 10.1016/j.steroids.2019.03.012

    PMID: 30951758

    		 Sample: Cell culture supernatant
  99. Journal of the Science of Food and Agriculture (2019) IF: 2.379
    Effect and mechanism of citral against methicillin-resistant Staphylococcus aureus in vivo

    DOI: 10.1002/jsfa.9677

    PMID: 30891759

    		 Sample: Serum
  100. Journal of cellular biochemistry (2019) IF: 2.959
    Attractylone Attenuates Sepsis-Associated Encephalopathy and Cognitive Dysfunction by Inhibiting Microglial Activation and Neuroinflammation

    DOI: 10.1002/jcb.27983

    PMID: 30672013

    		 Sample: Cell culture supernatant,Tissue homogenate
  101. Gene (2019) IF: 2.498
    The inhibition of microRNA-203 on ischemic reperfusion injury after total knee arthroplasty via suppressing MYD88-mdiated toll-like receptor signaling pathway

    DOI: 10.1016/j.gene.2019.02.030

    PMID: 30772517

    		 Sample: Tissue homogenate
  102. Inflammation (2019) IF: 2.884
    Sinomenine Attenuates Cartilage Degeneration by Regulating miR-223-3p/NLRP3 Inflammasome Signaling

    DOI: 10.1007/s10753-019-00986-3

    PMID: 30847744

    		 Sample: Serum,Cell culture supernatant
  103. Biomedical and Environmental Sciences (2018) IF: 2.518
    Effects of Simulated Heat Wave and Ozone on High Fat Diet ApoE Deficient Mice.

    DOI: 10.3967/bes2018.101

    PMID: 30423277

    		 Sample: Plasma,Tissue homogenate
  104. Plos One (2017) IF: 2.806
    Therapeutic Effect Of imiquimod On Dextran Sulfate Sodium-induced Ulcerative Colitis In Mice.

    DOI: 10.1371/journal.pone.0186138

    PMID: 29049372

    		 Sample: Serum
  105. PloS one (2017) IF: 2.806
    Chronic administration of mitochondrion-targeted peptide SS-31 prevents atherosclerotic development in ApoE knockout mice fed Western diet.

    DOI: 10.1371/journal.pone.0185688

    PMID: 28961281

    		 Sample: Serum
  106. International Immunopharmacology (2017) IF: 2.956
    Wogonin Attenuates Inflammation By Activating PPAR-γ In Alcoholic Liver Disease.

    DOI: 10.1016/j.intimp.2017.06.013

    PMID: 28646664

    		 Sample: Serum,Cell culture supernatant
  107. Molecules (2017) IF: 2.861
    Capparis Spinosa Fruit Ethanol Extracts Exert Different Effects On The Maturation Of Dendritic Cells.

    DOI: 10.3390/molecules22010097

    PMID: 28067853

    		 Sample: Cell culture supernatant
  108. Biochemical & Biophysical Research Communications (2015) IF: 2.466
    Ghrelin Ameliorates Intestinal Barrier Dysfunction In Experimental Colitis By Inhibiting The Activation Of Nuclear Factor-Kappa B.

    DOI: 10.1016/j.bbrc.2015.01.083

    PMID: 25634696

    		 Sample: Tissue homogenate
  109. Food Science & Nutrition (2020) IF: 1.797
    Subcutaneous administration of casein attenuates atherosclerotic progression in male apoE -/- mice fed with high-fat diet

    DOI: 10.1002/fsn3.1638

    PMID: 32724618

    		 Sample: Plasma
  110. Experimental and Therapeutic Medicine (2020) IF: 1.785
    Clostridium butyricum protects intestinal barrier function via upregulation of tight junction proteins and activation of the Akt/mTOR signaling pathway in a mouse model of dextran sodium sulfate-induced colitis

    DOI: 10.3892/etm.2020.9138

    PMID: 32934675

    		 Sample: Serum
  111. Current Medical Science (2020) IF: 1.273
    Role of Interleukin 17A in Aortic Valve Inflammation in Apolipoprotein E-deficient Mice

    DOI: 10.1007/s11596-020-2230-0

    PMID: 32862384

    		 Sample: Plasma
  112. Asian Pacific Journal of Tropical Medicine (2019) IF: 1.94
    Alpinia officinarum Hance extract alleviates particulate matter-induced lung injury in mice

    DOI: 10.4103/1995-7645.272487

    PMID: 99999999

    		 Sample: Serum,Bronchoalveolar Lavage Fluid,Tissue homogena
  113. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research (2020) IF: 1.918
    The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid

    DOI: 10.12659/MSM.919220

    PMID: 32026851

    		 Sample: Serum,Cell culture supernatant,Tissue homogenate
  114. Current medical science (2019) IF: 1.273
    Berberine Attenuates Cigarette Smoke Extract-induced Airway Inflammation in Mice: Involvement of TGF-β1/Smads Signaling Pathway

    DOI: 10.1007/s11596-019-2101-8

    PMID: 31612392

    		 Sample: Bronchoalveolar Lavage Fluid
  115. Canadian journal of physiology and pharmacology (2019) IF: 1.946
    Role of Brd4 in the production of inflammatory cytokines in mouse macrophages treated with titanium particles

    DOI: 10.1139/cjpp-2019-0142

    PMID: 31330113

    		 Sample: Cell culture supernatant
  116. Experimental and therapeutic medicine (2018) IF: 1.41
    miR-148a inhibits pro-inflammatory cytokines released by intervertebral disc cells by regulating the p38/MAPK pathway

    DOI: 10.3892/etm.2018.6516

    PMID: 30186499

    		 Sample: Cell culture supernatant
  117. Medical molecular morphology (2019) IF: 1.217
    The therapeutic effects of resveratrol on hepatic steatosis in high-fat diet-induced obese mice by improving oxidative stress, inflammation and lipid-related gene transcriptional expression

    DOI: 10.1007/s00795-019-00216-7

    PMID: 30673851

    		 Sample: Serum,Tissue homogenate
  118. Cellular & molecular biology letters (2019) IF: 1.291
    Tetrahydroxy stilbene glucoside alleviates palmitic acid-induced inflammation and apoptosis in cardiomyocytes by regulating miR-129-3p/Smad3 signaling

    DOI: 10.1186/s11658-018-0125-x

    PMID: 30820195

    		 Sample: Cell culture supernatant
  119. Journal of biochemical and molecular toxicology (2019) IF: 1.837
    Gastrodin attenuates neuroinflammation in DOI-induce Tourette syndrome in rats

    DOI: 10.1002/jbt.22302

    PMID: 30790395

    		 Sample: Serum,Tissue homogenate
  120. Cellular & molecular biology letters (2019) IF: 1.291
    Honokiol alleviates sepsis-induced acute kidney injury in mice by targeting the miR-218-5p/heme oxygenase-1 signaling pathway

    DOI: 10.1186/s11658-019-0142-4

    PMID: 30833971

    		 Sample: Serum
  121. Reproduction, Fertility and Development (2019) IF: 1.723
    Notch signalling regulates steroidogenesis in mouse ovarian granulosa cells

    DOI: 10.1071/RD18281

    PMID: 30827331

    		 Sample: Cell culture medium
  122. Oncology Letters (2018) IF: 1.39
    The Association Between Inflammation, The Microbiome and Urethane-induced Pulmonary Adenocarcinoma.

    DOI: 10.3892/ol.2018.8167

    PMID: 29725395
  123. Molecular Medicine Reports (2018) IF: 1.692
    Oral supplementation with ursolic acid ameliorates sepsis-induced acute kidney injury in a mouse model by inhibiting oxidative stress and inflammatory responses.

    DOI: 10.3892/mmr.2018.8767

    PMID: 29568928
  124. International Journal of Clinical and Experimental Pathology (2015) IF: 1.706
    An Unusual Case Of Iron Deficiency Anemia Is Associated With Extremely Low Level Of Transferrin Receptor.

    PMID: 26339443

    		 Sample: Serum
  125. International Journal of Clinical and Experimental Medicine (2015) IF: 1.069
    Sulfated Modification Promotes The Immunomodulatory Bioactivities Of Lyciumbarbarum Polysaccharides In Vitro.

    PMID: 26884954

    		 Sample: Cell culture supernatant
  126. Journal of Oleo Science (2015) IF: 1.076
    A Comparative Study Of The Effects Upon LPS Induced Macrophage RAW264.7 Inflammation In Vitro Of The Lipids Of Hippocampus Trimaculatus Leach.

    DOI: 10.5650/jos.ess15190

    PMID: 26582156

    		 Sample: Cell culture supernatant
  127. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research (2020)
    Methamphetamine induced neuroinflammation in mouse brain and microglial cell line BV2: Roles of the TLR4/TRIF/Peli1 signaling axis

    DOI: 10.1016/j.toxlet.2020.07.028

    PMID: 32768653

    		 Sample: Cell culture supernatant,Tissue homogenate
  128. Advances in Pharmacological and Pharmaceutical Sciences (2020)
    Antihypernociceptive, Anxiolytic, and Antidepressant Properties of Aqueous and Ethanol Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Mice

    DOI: 10.1155/2020/8886894

    PMID: 33015629

    		 Sample: Serum,Tissue homogenate
  129. The FASEB Journal (2020)
    CaMK4-dependent phosphorylation of Akt/mTOR underlies Th17 excessive activation in experimental autoimmune prostatitis

    DOI: 10.1096/fj.201902910RRR

    PMID: 32862457

    		 Sample: Cell culture supernatant,Tissue homogenate
  130. Jurnal Kedokteran Brawijaya (2020)
    The Effects of Thyme on IL-6 Level and the Bacterial Count in the Brain and Spleen of Mice Infected by Methicillin-Resistant Staphylococcus aureus (MRSA)

    DOI: 10.21776/ub.jkb.2020.031.01.1

    PMID: 99999999

    		 Sample: Plasma
  131. bioRxiv (2020)
    Fecal microbiota transplantation reconstructs the gut microbiota of septic mice and protects the intestinal mucosal barrier

    DOI: 10.1101/2020.06.22.164541

    PMID: 99999999

    		 Sample: Serum
  132. SSRN (2020)
    Salidroside Attenuates Liver Injury in Diabetes Mice

    DOI: 10.2139/ssrn.3546025

    PMID: 99999999

    		 Sample: Serum,Cell culture supernatant,Tissue homogenate
  133. Journal of Cellular and Molecular Medicine (2020)
    Polysaccharides from Dicliptera chinensis ameliorate liver disturbance by regulating TLR-4/NF-κB and AMPK/Nrf2 signalling pathways

    DOI: 10.1111/jcmm.15286

    PMID: 32337831

    		 Sample: Serum,Tissue homogenate
  134. Open access Macedonian journal of medical sciences (2019)
    Neuroprotective Activity of Evolvulus alsinoides & Centella asiatica Ethanolic Extracts in Scopolamine-Induced Amnesia in Swiss Albino Mice

    DOI: 10.3889/oamjms.2019.247

    PMID: 31049081

    		 Sample: Tissue homogenate
  135. Veterinary world (2019)
    Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle

    DOI: 10.14202/vetworld.2019.684-688

    PMID: 31327904

    		 Sample: Tissue homogenate
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