MVP Polyclonal Antibody

Uniprot : Q14764
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14194

      Synonyms:LRP,Lung resistance related protein,Lung resistance-related protein,Major vault protein,Major vault protein,rat,homolog of,MVP,MVP,testicular secretory protein Li 30,VAULT 1,VAULT1

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms LRP,Lung resistance related protein,Lung resistance-related protein,Major vault protein,Major vault protein,rat,homolog of,MVP,MVP,testicular secretory protein Li 30,VAULT 1,VAULT1
      Swissprot Q14764
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human MVP
      Application WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:25-1:100
      Concentration 0.3 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm. Nucleus>nuclear pore complex. 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.
      Tissue specificity Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.

      Images

      Western Blot analysis of 231 cell and Mouse kidney tissue using MVP Polyclonal Antibody at dilution of 1:500

      Immunohistochemistry of paraffin-embedded Human lung cancer using MVP Polyclonal Antibody at dilution of 1:40

      Immunohistochemistry of paraffin-embedded Human esophagus cancer using MVP Polyclonal Antibody at dilution of 1:40

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