NBR1 Monoclonal Antibody

Uniprot : Q14596
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
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    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience

      Catalog number:E-AB-22148

      Synonyms:1A1 3B,1A13B,B box protein,Cell migration-inducing gene 19 protein,KIAA0049,M17S2,Membrane component chromosome 17 surface marker 2,Membrane component,chromosome 17,surface marker 2 (ovarian carcinoma antigen CA125),MIG 19,MIG19,Migration inducing protein 19,NBR 1,Nbr1,NBR1,autophagy cargo receptor,NBR1,Neighbor of BRCA1 gene 1,Neighbor of BRCA1 gene 1 protein,Next to BRCA1 gene 1 protein,Ovarian carcinoma antigen CA125,Protein 1A1-3B

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Mouse

      Reactivity: H,M,R

      Applications: IHC-p,IF

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms 1A1 3B,1A13B,B box protein,Cell migration-inducing gene 19 protein,KIAA0049,M17S2,Membrane component chromosome 17 surface marker 2,Membrane component,chromosome 17,surface marker 2 (ovarian carcinoma antigen CA125),MIG 19,MIG19,Migration inducing protein 19,NBR 1,Nbr1,NBR1,autophagy cargo receptor,NBR1,Neighbor of BRCA1 gene 1,Neighbor of BRCA1 gene 1 protein,Next to BRCA1 gene 1 protein,Ovarian carcinoma antigen CA125,Protein 1A1-3B
      Swissprot Q14596
      Source Mouse
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant Protein of NBR1
      Application IHC-p(Detection kit: E-IR-R217),IF
      Recommended dilution IHC 1:50-300, IF 1:50-1:200
      Concentration 1 mg/mL
      Clonality Monoclonal

      Properties

      Cellular localization Cytoplasm. Cytoplasmic vesicle>autophagosome. Lysosome. Cytoplasm>myofibril>sarcomere>M line. In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation.
      Clone No. Clone:4C6
      Isotype IgG
      Purification Protein A purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
      Background The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.NBR1 (NBR1, Autophagy Cargo Receptor) is a Protein Coding gene. Diseases associated with NBR1 include Inclusion Body Myositis and Synucleinopathy. Among its related pathways are Mitophagy - animal. GO annotations related to this gene include ubiquitin binding and mitogen-activated protein kinase binding.

      Images

      monoclonal antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Rat lung tissue using NBR1 Monoclonal Antibody at dilution of 1:200.

      monoclonal antibody-Elabscience

      Immunofluorescence analysis of Rat spleen tissue using NBR1 Monoclonal Antibody at dilution of 1:200.

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