NFATC3 Polyclonal Antibody

Uniprot : Q12968
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14243

      Synonyms:C80703,cytoplasmic 3,D8Ertd281e,NF AT4,NF ATc3,NF-AT4,NF-ATc3,NFAC3,NFATc3,NFATx,Nuclear factor of activated T cells,cytoplasmic 3,nuclear factor of activated T cells,cytoplasmic,calcineurin dependent 3,Nuclear factor of activated T-cells,T cell transcription factor NFAT4,T-cell transcription factor NFAT4

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms C80703,cytoplasmic 3,D8Ertd281e,NF AT4,NF ATc3,NF-AT4,NF-ATc3,NFAC3,NFATc3,NFATx,Nuclear factor of activated T cells,cytoplasmic 3,nuclear factor of activated T cells,cytoplasmic,calcineurin dependent 3,Nuclear factor of activated T-cells,T cell transcription factor NFAT4,T-cell transcription factor NFAT4
      Swissprot Q12968
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Recombinant protein of human NFATC3
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:100-1:300
      Concentration 0.7 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
      Tissue specificity Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. 

      Images

      Immunohistochemistry of paraffin-embedded Human liver cancer tissue using NFATC3 Polyclonal Antibody at dilution 1:60

      Immunohistochemistry of paraffin-embedded Human colon cancer tissue using NFATC3 Polyclonal Antibody at dilution 1:60

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