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NUAK1 Polyclonal Antibody

Cat:E-AB-12986
Manual MSDS

Price: $ 399

Price: $ 240

Price: $ 143

Price: $ 73

Size:
200μL 120μL 60μL 20μL
Quantity:
  • Host: Rabbit
  • Reactivity: Human;Mouse
  • Applications: IHC
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Product Details
Verified Samples Verified Samples in IHC:Human lung cancer
Dilution

IHC 1:25-1:100

Western Blot Operation Guide
Clonality Polyclonal
Immunogen Synthetic peptide of human NUAK1
Abbre NUAK1
Synonyms AMP activated protein kinase family member 5;AMPK related protein kinase 5;AMPK-related protein kinase 5;NUAK family SNF1 like kinase;NUAK family SNF1-like kinase 1;Nuak1;NUAK1;Omphalocele kinase 1;Probable serine/threonine protein kinase KIAA0537
Swissprot
Cellular Localization Cytoskeleton,microtubule cytoskeleton,Nucleus,fibrillar center,nucleoplasm,nucleus,Other locations:cytoplasm
Concentration 0.6 mg/mL
Buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method Affinity purification
Research Areas Cancer; Signal Transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping Biological ice pack at 4 ℃
background NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5(ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.