|Background||P16, also known as "mitosis inhibitor", is one of the cell cycle regulatory proteins. It competitively binds to CDK4 / 6 with cyclin D, prevents cells entering to S phase from G1 phase, it is negatively regulating mitosis. In tumor cells, p16 expression is often increased due to gene mutation or deletion. P16 is closely related to cervical cancer caused by HPV infection. P16 is overexpressed in high-risk squamous epithelium injury (HSIL). p16 expression in low-risk squamous epithelium injury (LSIL) is Weak or medium, while there is no p16 expression in normal cervical epithelium. Therefore, p16 is helpful to study the grading of cervical epithelial neoplasia.|
Immunohistochemistry of paraffinembedded Human cervical squamous cell carcinoma with P16 Monoclonal Antibody(Antigen repaired by EDTA).