p70 S6 kinase alpha Monoclonal Antibody
Price: $ 399
Price: $ 240
Price: $ 143
Price: $ 73
Size:
200μL
120μL
60μL
20μL
Quantity:
- Host: Mouse
- Reactivity: Human;Mouse;Rat
- Applications: IHC-p
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Product Details
Verified Samples |
Verified Samples in IHC:Human lung carcinoma,Human breast carcinoma |
Dilution |
IHC 1:100-200 Western Blot Operation Guide |
Clonality | Monoclonal |
Immunogen | Recombinant Protein of P70 S6 Kinase of RPS6KB1 |
Abbre | p70 S6 kinase alpha |
Synonyms | 70 kDa ribosomal protein S6 kinase 1;KS6B1;p70 alpha;P70 beta 1;p70 ribosomal S6 kinase alpha;p70 ribosomal S6 kinase beta 1;p70 S6 kinase alpha;P70 S6 Kinase;p70 S6 kinase;alpha 1;p70 S6 kinase;alpha 2;p70 S6K;p70 S6K-alpha;p70 S6KA;p70(S6K) alpha;p70(S6K)-alpha;p70-alpha;p70-S6K 1;p70-S6K;P70S6K;P70S6K1;p70S6Kb;PS6K;Ribosomal protein S6 kinase 70kDa polypeptide 1;Ribosomal protein S6 kinase beta 1;Ribosomal protein S6 kinase beta-1;Ribosomal protein S6 kinase I;RPS6KB1;S6K;S6K-beta-1;S6K1;Serine/threonine kinase 14 alpha;Serine/threonine-protein kinase 14A;STK14A |
Swissprot | |
Cellular Localization | Cytoplasm; Nucleus. Cytoplasm and Cell junction>synapse>synaptosome. Mitochondrion outer membrane. |
Tissue Specificity | Widely expressed. |
Concentration | 1 mg/mL |
Buffer | PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4 |
Purification Method | Protein A purification |
Research Areas | Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Metabolism; Signal Transduction |
Clone No. | Clone:1C7 |
Conjugation | Unconjugated |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Shipping | Biological ice pack at 4 ℃ |
background | P70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. |
Experiment Operation Video
Protocols
• Western Blot Guide
• Immunohistochemistry Guide for Slide-mounted Paraffin Sections
• Immunofluorescence Guide
• Immunohistochemistry Troubleshooting Tips
• Western Blot Troubleshooting Tips
• Immunofluorescence Troubleshooting Tips
• Comparison of Protein Separation Linear Range
• ImmunoPrecipitation Protocol