p70 S6 kinase alpha Monoclonal Antibody

Uniprot : P23443
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
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    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience

      Catalog number:E-AB-22198

      Synonyms:70 kDa ribosomal protein S6 kinase 1,KS6B1,p70 alpha,P70 beta 1,p70 ribosomal S6 kinase alpha,p70 ribosomal S6 kinase beta 1,p70 S6 kinase alpha,P70 S6 Kinase,p70 S6 kinase,alpha 1,p70 S6 kinase,alpha 2,p70 S6K,p70 S6K-alpha,p70 S6KA,p70(S6K) alpha,p70(S6K)-alpha,p70-alpha,p70-S6K 1,p70-S6K,P70S6K,P70S6K1,p70S6Kb,PS6K,Ribosomal protein S6 kinase 70kDa polypeptide 1,Ribosomal protein S6 kinase beta 1,Ribosomal protein S6 kinase beta-1,Ribosomal protein S6 kinase I,RPS6KB1,S6K,S6K-beta-1,S6K1,Serine/threonine kinase 14 alpha,Serine/threonine-protein kinase 14A,STK14A

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Mouse

      Reactivity: H,M,R

      Applications: IHC-p

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms 70 kDa ribosomal protein S6 kinase 1,KS6B1,p70 alpha,P70 beta 1,p70 ribosomal S6 kinase alpha,p70 ribosomal S6 kinase beta 1,p70 S6 kinase alpha,P70 S6 Kinase,p70 S6 kinase,alpha 1,p70 S6 kinase,alpha 2,p70 S6K,p70 S6K-alpha,p70 S6KA,p70(S6K) alpha,p70(S6K)-alpha,p70-alpha,p70-S6K 1,p70-S6K,P70S6K,P70S6K1,p70S6Kb,PS6K,Ribosomal protein S6 kinase 70kDa polypeptide 1,Ribosomal protein S6 kinase beta 1,Ribosomal protein S6 kinase beta-1,Ribosomal protein S6 kinase I,RPS6KB1,S6K,S6K-beta-1,S6K1,Serine/threonine kinase 14 alpha,Serine/threonine-protein kinase 14A,STK14A
      Swissprot P23443
      Source Mouse
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant Protein of P70 S6 Kinase of RPS6KB1
      Application IHC-p(Detection kit: E-IR-R217)
      Recommended dilution IHC 1:100-200
      Concentration 1 mg/mL
      Clonality Monoclonal

      Properties

      Cellular localization Cytoplasm; Nucleus. Cytoplasm and Cell junction>synapse>synaptosome. Mitochondrion outer membrane.
      Tissue specificity Widely expressed.
      Clone No. Clone:1C7
      Isotype IgG
      Purification Protein A purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background P70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.

      Images

      monoclonal antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Human lung carcinoma tissue using p70 S6 kinase alpha Monoclonal Antibody at dilution of 1:200.

      monoclonal antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using p70 S6 kinase alpha Monoclonal Antibody at dilution of 1:200.

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