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PE Anti-Mouse IL-17A Antibody[17F3]

  • Cat.No.:E-AB-F1272D

  • Applications: ICFCM
  • Isotype: Mouse IgG1, κ
  • Host: Mouse

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Antigen Details

Alternate Names Interleukin-17A,Il17a,Ctla8
Swissprot Q62386
Gene ID 16171
References
1. Faraco,G, et al. 2018. Nat Neurosci. 21(2): 240-249.
2. Xiong H, et al. 2016. Cell. 03.017.
3. Coffelt S, et al. 2015. Nature. 522(7556): 345-348.
4. Naik S, et al. 2015. Nature. 520(7545): 104-108.
5. Sell S, et al. 2015. PLoS Pathog. 11(2): e1004481.

Product Details

Form Liquid
Clone No. 17F3(See Other Available Formats)
Host Mouse
Isotype Mouse IgG1, κ
Isotype Control PE Mouse IgG1, κ Isotype Control[MOPC-21] [Product E-AB-F09792D]
Reactivity Mouse
Application ICFCM (See the Application Description)
Storage Buffer Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Recommended Use Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Shipping Biological ice pack at 4℃
Stability & Storage Keep as concentrated solution.
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Centrifuge before opening to ensure complete recovery of vial contents.
This product is guaranteed up to one year from purchase.
Conjugation PE
PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter).


How to select the appropriate detection channel through the spectrogram?

Background

The 17F3 monoclonal antibody reacts with mouse IL-17A a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. IL-17A has pleiotropic effects in immunoregulation and inflammation. It plays an important role in anti-microbial and chronic inflammation by inducing cytokine and chemokine production, neutrophil influx, and the production of antibacterial peptides but it is also an inflammatory mediator in the development of autoimmune diseases including rheumatoid arthritis, asthma, multiple sclerosis, and psoriasis. The 17F3 antibody has been shown to neutralize IL-21A in vivo.

Protocols & Troubleshootings

Related Protocols Staining Intracellular Antigens for Flow Cytometry
Troubleshooting

Troubleshooting for Flow Cytometry

Citations

From now on, if you have published a paper by using any of our products since 1/1/2019, fill out the “Elabscience Publication Reward Application Form”carefully and send it to orders@elabscience.com, we will get back to you with the reward after we confirm it ASAP!

View more details about our Publication Reward >>

  1. Food & Function (2021) IF: 5.396
    Dendrobium fimbriatum Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function, modulating intestinal microbiota, reducing oxidative stress and inflammatory responses

    DOI: 10.1039/D1FO03003E

    Sample: LPCs cells

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