PerCP/Cyanine5.5 Anti-Human CD107a/LAMP-1 Antibody[H4A3] E-AB-F1149J

Uniprot : P11279
  • Host: Mouse
  • Applications: FCM
  • Isotype: Mouse IgG1, κ

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Antigen Details

Alternate Names Lysosome-Associated Membrane Protein 1, LGP-120, LAMP-1
Swissprot P11279
References
1. Sarafian V, et al. 2006. Arch. Dermatol. Res. 298:7381.
2. Schlossman SF, et al. 1995. Leukocyte Typing V:White Cell Differentiation Antigens. New York:Oxford University Press.
3. Sawada R, et al. 1993. J. Biol. Chem. 268:12675.
4. Chen JW, et al. 1988. J. Biol. Chem. 263:8754.
5. Chen JW, et al. 1986. Biochem. Soc. Symp. 51:97112.

Product Details

Form Liquid
Clone No. H4A3(See Other Available Formats)
Host Mouse
Isotype Mouse IgG1, κ
Isotype Control PerCP/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21] [Product E-AB-F09792J]
Reactivity Human
Application FCM (See the Application Description)
Storage Buffer PBS with 0.05% Proclin300, 1% BSA
Recommended Use Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent is suggested to be used 2 μL or 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Shipping Biological ice pack at 4℃
Stability & Storage Keep as concentrated solution.
Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.
Centrifuge before opening to ensure complete recovery of vial contents.
This product is guaranteed up to one year from purchase.
Conjugation PerCP/Cyanine5.5

Background

CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.

Protocols & Troubleshootings

Related Protocols Staining Cell Surface Targets for Flow Cytometry
Troubleshooting

Troubleshooting for Flow Cytometry

Alternative Formats

Cat.No. Product Name Sizes
E-AB-F1149C FITC Anti-Human CD107a/LAMP-1 Antibody[H4A3] E-AB-F1149C 20 Tests, 50 Tests, 100 Tests, 200 Tests
E-AB-F1149D PE Anti-Human CD107a/LAMP-1 Antibody[H4A3] E-AB-F1149D 20 Tests, 50 Tests, 100 Tests, 200 Tests
E-AB-F1149E APC Anti-Human CD107a/LAMP-1 Antibody[H4A3] E-AB-F1149E 20 Tests, 50 Tests, 100 Tests, 200 Tests
E-AB-F1149J PerCP/Cyanine5.5 Anti-Human CD107a/LAMP-1 Antibody[H4A3] E-AB-F1149J 20 Tests, 50 Tests, 100 Tests, 200 Tests

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