Phospho-ATM (Ser1981) Polyclonal Antibody

Uniprot : Q13315
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    • methyl antibody-Elabscience
    • methyl antibody-Elabscience
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    • methyl antibody-Elabscience
    • methyl antibody-Elabscience
    • methyl antibody-Elabscience
    • methyl antibody-Elabscience
    • methyl antibody-Elabscience
    • methyl antibody-Elabscience

      Catalog number:E-AB-21540

      Synonyms:A-T mutated,A-T mutated homolog,AT mutated,AT1,ATA,Ataxia telangiectasia mutated,Ataxia telangiectasia mutated gene,Ataxia telangiectasia mutated homolog (human),Ataxia telangiectasia mutated homolog,ATC,ATD,ATDC,ATE,ATM,ATM serine/threonine kinase,ATM,DKFZp781A0353,MGC74674,OTTHUMP00000232981,Serine protein kinase ATM,Serine-protein kinase ATM,Serine/threonine-protein kinase ATM,Tefu,TEL1,TEL1,telomere maintenance 1,homolog,TELO1,Telomere fusion protein

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: WB,IHC-p,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms A-T mutated,A-T mutated homolog,AT mutated,AT1,ATA,Ataxia telangiectasia mutated,Ataxia telangiectasia mutated gene,Ataxia telangiectasia mutated homolog (human),Ataxia telangiectasia mutated homolog,ATC,ATD,ATDC,ATE,ATM,ATM serine/threonine kinase,ATM,DKFZp781A0353,MGC74674,OTTHUMP00000232981,Serine protein kinase ATM,Serine-protein kinase ATM,Serine/threonine-protein kinase ATM,Tefu,TEL1,TEL1,telomere maintenance 1,homolog,TELO1,Telomere fusion protein
      Swissprot Q13315
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Synthesized peptide derived from human Atm around the phosphorylation site of Ser1981
      Application WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R217),ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:50-1:200, ELISA 1:5000-1:20000
      Concentration 1 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus. Cytoplasmic vesicle. Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin.
      Tissue specificity Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

      Images

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      Western Blot analysis of K562 cells with Phospho-Atm (Ser1981) Polyclonal Antibody at dilution of 1:500

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