Phospho-MLKL (Ser358) Monoclonal Antibody

Uniprot : Q8NB16
    • methyl antibody-Elabscience
    • methyl antibody-Elabscience
    • methyl antibody-Elabscience
    • methyl antibody-Elabscience
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    • methyl antibody-Elabscience
    • methyl antibody-Elabscience
    • methyl antibody-Elabscience
    • methyl antibody-Elabscience
    • methyl antibody-Elabscience
    • methyl antibody-Elabscience
    • methyl antibody-Elabscience
    • methyl antibody-Elabscience

      Catalog number:E-AB-21338

      Synonyms:9130019I15Rik,FLJ34389,hMLKL,Mixed lineage kinase domain like,Mixed lineage kinase domain like protein,Mixed lineage kinase domain like pseudokinase,Mixed lineage kinase domain-like protein,Mlkl,MLKL

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Mouse

      Reactivity: H

      Applications: IHC-p

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms 9130019I15Rik,FLJ34389,hMLKL,Mixed lineage kinase domain like,Mixed lineage kinase domain like protein,Mixed lineage kinase domain like pseudokinase,Mixed lineage kinase domain-like protein,Mlkl,MLKL
      Swissprot Q8NB16
      Source Mouse
      Reactivity Human
      Immunogen Synthetic Peptide of Phospho-MLKL (Ser358)
      Application IHC-p(Detection kit: E-IR-R217)
      Recommended dilution IHC 1:100-200
      Concentration 1 mg/mL
      Clonality Monoclonal

      Properties

      Cellular localization Cytosol,Plasma Membrane,Other locations:cytoplasm
      Clone No. Clone:6E3
      Isotype IgG
      Purification Protein A purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.MLKL (Mixed Lineage Kinase Domain Like Pseudokinase) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

      Images

      methyl antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Human colon carcinoma tissue with Phospho-MLKL (Ser358) Monoclonal Antibody at dilution of 1:200

      methyl antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Human skin tissue with Phospho-MLKL (Ser358) Monoclonal Antibody at dilution of 1:200

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