PIM1 Polyclonal Antibody

Uniprot : P11309
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    >
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14694

      Synonyms:Oncogene PIM 1,Oncogene PIM1,PIM 1,pim 1 kinase 44 kDa isoform,Pim 1 kinase,pim 1 oncogene (proviral integration site 1),Pim 1 oncogene,PIM,PIM1,pim1 kinase 44 kDa isoform,PIM1,Pim2,PIM3,Proto oncogene serine/threonine protein kinase Pim 1,Proto-oncogene serine/threonine-protein kinase Pim-1,Proviral integration site 1,Proviral integration site 2

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Oncogene PIM 1,Oncogene PIM1,PIM 1,pim 1 kinase 44 kDa isoform,Pim 1 kinase,pim 1 oncogene (proviral integration site 1),Pim 1 oncogene,PIM,PIM1,pim1 kinase 44 kDa isoform,PIM1,Pim2,PIM3,Proto oncogene serine/threonine protein kinase Pim 1,Proto-oncogene serine/threonine-protein kinase Pim-1,Proviral integration site 1,Proviral integration site 2
      Swissprot P11309
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human PIM1
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:25-1:100
      Concentration 0.4 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm. Nucleus and Cell membrane.
      Tissue specificity Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
      Background The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons.

      Images

      Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PIM1 Polyclonal Antibody at dilution 1:50

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