PPARA Polyclonal Antibody (E-AB-70253)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Mouse colon, Mouse kidney, Rat liver |
| Dilution | IHC 1:200-1:500 |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse PPARα |
| Abbre | PPARA |
| Synonyms | MGC2237, MGC2452, NR1C1, Nuclear receptor subfamily 1 group C member 1, OTTHUMP00000197740, OTTHUMP00000197741, Peroxisome proliferative activated receptor alpha, Peroxisome proliferator activated receptor alpha, Peroxisome proliferator-activated receptor a, hPPAR |
| Swissprot | |
| Cellular Localization | Nucleus. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acid β-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-κB, causing inhibition of its signaling pathway or reducing the activated levels of NF-κB and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 (CYP2E1), acyl-CoA oxidase, and NADPH oxidase. |
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