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pVHL Polyclonal Antibody

Cat:E-AB-10671
Manual MSDS

Price: $ 399

Price: $ 240

Price: $ 143

Price: $ 73

Size:
200μL 120μL 60μL 20μL
Quantity:
  • Host: Rabbit
  • Reactivity: Human
  • Applications: IHC
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Product Details
Verified Samples Verified Samples in IHC:Human cervical cancer,Human thyroid cancer
Dilution

IHC 1:50-1:200

Western Blot Operation Guide
Clonality Polyclonal
Immunogen Recombinant protein of human VHL
Abbre VHL
Synonyms Elongin binding protein;G7 protein;HRCA 1;HRCA1;Protein G7;pVHL;RCA 1;RCA1;VHL 1;VHL;VHL;VHL1;VHLH;Von Hippel Lindau disease tumor suppressor;von Hippel Lindau syndrome;von Hippel Lindau tumor suppressor;Von Hippel Lindau tumor suppressor;E3 ubiquitin protein ligase;Von Hippel-Lindau disease tumor suppressor
Swissprot
Cellular Localization Cytoplasm, Nucleus
Concentration 0.4 mg/mL
Buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method Affinity purification
Research Areas Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Metabolism
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping Biological ice pack at 4 ℃
background Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.