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Rat IL-1β(Interleukin 1 Beta) ELISA Kit

Citations(437)Uniprot : Q63264

  • Cat.No.:E-EL-R0012

  • Reactivity: Rat
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Manual MSDS

To Purchase E-EL-R0012

Size:
  • 96T
  • 48T
  • 24T
  • 96T*5
  • 96T*10
Price: $495
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Product Details

Properties

Assay type Sandwich-ELISA
Format 96T/48T
Assay time 3.5h
Detection range 31.25-2000 pg/mL
Sensitivity 18.75 pg/mL
Sample type &Sample volume serum, plasma and other biological fluids; 100μL
Specificity This kit recognizes Rat IL-1β in samples. No significant cross-reactivity or interference between Rat IL-1β and analogues was observed.
Reproducibility Both intra-CV and inter-CV are < 10%.
Application This ELISA kit applies to the in vitro quantitative determination of Rat IL-1β concentrations in serum, plasma and other biological fluids.

Test Principle

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat IL-1β. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Rat IL-1β and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Rat IL-1β, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of Rat IL-1β. You can calculate the concentration of Rat IL-1β in the samples by comparing the OD of the samples to the standard curve.

Kit components & Storage

An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the components separately according to the following conditions once the kit is received.
ItemSpecificationsStorage
Micro ELISA Plate(Dismountable) 96T: 8 wells ×12 strips
48T: 8 wells ×6 strips 		-20℃, 6 months
Reference Standard 96T: 2 vials
48T: 1 vial
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL 		-20℃(Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL
HRP Conjugate Diluent 1 vial, 14 mL
Concentrated Wash Buffer (25×) 1 vial, 30 mL
Substrate Reagent 1 vial, 10 mL 2-8℃(Protect from light)
Stop Solution 1 vial, 10 mL 2-8°C
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Technical Data

Precision

Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Rat IL-1β were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Rat IL-1β were tested on 3 different plates, 20 replicates in each plate.

  Intra-assay Precision Inter-assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (pg/mL) 100.50 314.20 880.10 107.40 340.60 954.80
Standard deviation 5.70 13.50 30.80 5.60 20.40 33.40
CV (%) 5.67 4.30 3.50 5.21 5.99 3.50

Recovery

The recovery of Rat IL-1β spiked at three different levels in samples throughout the range of the assay was evaluated in various matrices.

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 85-98 91
EDTA plasma (n=8) 86-100 93
Cell culture media (n=8) 86-101 92

Linearity

Samples were spiked with high concentrations of Rat IL-1β and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

Target Information

Database LinksSwissProt:   Q63264
SynonymsIL1B, IL1-BETA, IL1F2, catabolin
Research AreaCancer, Cardiovascular, Metabolism, Immunology

Assay Procedures

elisa assay procedure 1

1. Add 100μL standard or sample to the wells. Incubate for 90 min at 37°C
elisa assay procedure 2

2. Discard the liquid, immediately add 100μL Biotinylated Detection Ab working solution to each well. Incubate for 60 min at 37°C
elisa assay procedure 3

3. Aspirate and wash the plate for 3 times
elisa assay procedure 4

4. Add 100μL HRP conjugate working solution. Incubate for 30 min at 37°C. Aspirate and wash the plate for 5 times
elisa assay procedure 5

5. Add 90μL Substrate Reagent. Incubate for 15 min at 37°C
elisa assay procedure 6

6. Add 50μL Stop Solution
elisa assay procedure 7

7. Read the plate at 450nm immediately. Calculation of the results

Citations

  1. CRITICAL CARE (2022) IF: 19.334
    Individualizing mechanical ventilation: titration of driving pressure to pulmonary elastance through Young’s modulus in an acute respiratory distress syndrome animal model

    DOI: 10.1186/s13054-022-04184-w

    PMID: 36258235

    		 Sample: bronchoalveolar lavages (BAL)
  2. Applied Materials Today (2022) IF: 10.041
    Preclinical studies of an automated radiolabeled microcarriers for radiosynovectomy of inflammatory joint disease

    DOI: 10.1016/j.apmt.2022.101571
    Sample: Serum
  3. CHEMISTRY OF MATERIALS (2022) IF: 10.508
    Biomechanically Compatible Hydrogel Bioprosthetic Valves

    DOI: 10.1021/acs.chemmater.2c01300
    Sample: blood
  4. ACS Applied Materials & Interfaces (2021) IF: 9.2289
    Self-Assembled pH-Sensitive Polymeric Nanoparticles for the Inflammation-Targeted Delivery of Cu/Zn-Superoxide Dismutase

    DOI: 10.1021/acsami.1c03589

    PMID: 33764751

    		 Sample: Plasma
  5. CELLULAR AND MOLECULAR LIFE SCIENCES (2016) IF: 9.2609
    toxin B

    DOI: 10.1007/s00018-016-2426-4
    Sample: Cell culture supernatant
  6. Journal of Neuroinflammation (2023) IF: 9.587
    Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy

    DOI: 10.1186/s12974-023-02715-y
    Sample: brain,serum
  7. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022) IF: 8.025
    Structural elucidation and anti-neuroinflammatory activity of Polygala tenuifolia polysaccharide

    DOI: 10.1016/j.ijbiomac.2022.08.161

    PMID: 36037912

    		 Sample: serum
  8. Stem Cell Research & Therapy (2022) IF: 8.0790
    Co-treatment with grape seed extract and mesenchymal stem cells in vivo regenerated beta cells of islets of Langerhans in pancreas of type I-induced diabetic rats

    DOI: 10.1186/s13287-022-03218-y
    Sample: pancreas
  9. Journal of Neuroinflammation (2021) IF: 8.3219
    Rifaximin-mediated gut microbiota regulation modulates the function of microglia and protects against CUMS-induced depression-like behaviors in adolescent rat

    DOI: 10.1186/s12974-021-02303-y

    PMID: 34736493

    		 Sample: brain
  10. Journal of Neuroinflammation (2021) IF: 8.3219
    EETs/sEHi alleviates nociception by blocking the crosslink between endoplasmic reticulum stress and neuroinflammation in a central poststroke pain model

    DOI: 10.1186/s12974-021-02255-3

    PMID: 34530836

    		 Sample: brain
  11. International Journal of Nanomedicine (2023) IF: 7.033
    Nano Parthenolide Improves Intestinal Barrier Function of Sepsis by Inhibiting Apoptosis and ROS via 5-HTR2A

    DOI: 10.2147/IJN.S394544
    Sample: blood
  12. CNS Neuroscience & Therapeutics (2022) IF: 7.035
    Effects of intraperitoneal injection of lipopolysaccharide-induced peripheral inflammation on dopamine neuron damage in rat midbrain

    DOI: 10.1111/cns.13906

    PMID: 35789066

    		 Sample: blood
  13. Oxidative Medicine and Cellular Longevity (2022) IF: 7.31
    Sacubitril Valsartan Enhances Cardiac Function and Alleviates Myocardial Infarction in Rats through a SUV39H1/SPP1 Axis.

    DOI: 10.1155/2022/5009289
    Sample: cardiac tissue
  14. Oxidative Medicine and Cellular Longevity (2022) IF: 7.31
    Exosomal miR-27b-3p Derived from Hypoxic Cardiac Microvascular Endothelial Cells Alleviates Rat Myocardial Ischemia/Reperfusion Injury through Inhibiting Oxidative Stress-Induced Pyroptosis via Foxo1/GSDMD Signaling

    DOI: 10.1155/2022/8215842

    PMID: 35847592

    		 Sample: Serum,H9C2 cell
  15. Oxidative Medicine and Cellular Longevity (2022) IF: 7.31
    Change in Oxidative Stress and Mitochondrial Dynamics in Response to Elevated Cold-Inducible RNA-Binding Protein in Cardiac Surgery-Associated Acute Kidney Injury

    DOI: 10.1155/2022/3576892

    PMID: 35855864

    		 Sample: serum
  16. BIOMEDICINE & PHARMACOTHERAPY (2023) IF: 7.419
    Quince extract resists atherosclerosis in rats by down-regulating the EGFR/PI3K/Akt/GSK-3β pathway

    DOI: 10.1016/j.biopha.2023.114330
  17. Cells (2022) IF: 7.666
    Melatonin Attenuates Spinal Cord Injury in Mice by Activating the Nrf2/ARE Signaling Pathway to Inhibit the NLRP3 Inflammasome

    DOI: 10.3390/cells11182809

    PMID: 36139384

    		 Sample: PC12 cell
  18. Cells (2022) IF: 7.666
    Hypoxia-Induced HIF-1α Expression Promotes Neurogenic Bladder Fibrosis via EMT and Pyroptosis

    DOI: 10.3390/cells11233836
    Sample: serum
  19. Cells (2022) IF: 7.666
    Forskolin, an Adenylcyclase/cAMP/CREB Signaling Activator Restoring Myelin-Associated Oligodendrocyte Destruction in Experimental Ethidium Bromide Model of Multiple Sclerosis

    DOI: 10.3390/cells11182771

    PMID: 36139346

    		 Sample: brain tissue
  20. Cells (2022) IF: 7.666
    Excessive Consumption Hibiscus sabdariffa L. Increases Inflammation and Blood Pressure in Male Wistar Rats via High Antioxidant Capacity: The Preliminary Findings

    DOI: 10.3390/cells11182774

    PMID: 36139349

    		 Sample: serum
  21. Antioxidants (2022) IF: 7.675
    Mangosteen Pericarp Extract Supplementation Boosts Antioxidant Status via Rebuilding Gut Microbiota to Attenuate Motor Deficit in 6-OHDA-Induced Parkinson’s Disease

    DOI: 10.3390/antiox11122396
    Sample: plasma
  22. FOOD AND CHEMICAL TOXICOLOGY (2021) IF: 6.025
    Reactive astrocytes induced by 2-chloroethanol modulate microglia polarization through IL-1β, TNF-α, and iNOS upregulation

    DOI: 10.1016/j.fct.2021.112550

    PMID: 34517076

    		 Sample: astrocyte
  23. Frontiers in Cardiovascular Medicine (2021) IF: 6.05
    Long Non-coding RNA N1LR Protects Against Myocardial Ischemic/Reperfusion Injury Through Regulating the TGF-β Signaling Pathway

    DOI: 10.3389/fcvm.2021.654969

    PMID: 34485393

    		 Sample: H9c2 cell
  24. Frontiers in Cellular and Infection Microbiology (2022) IF: 6.073
    Liujunanwei decoction attenuates cisplatin-induced nausea and vomiting in a Rat-Pica model partially mediated by modulating the gut micsrobiome

    DOI: 10.3389/fcimb.2022.876781

    PMID: 36061858

    		 Sample: jejunum tissue,medulla oblongata tissue
  25. American Journal of Cancer Research (2021) IF: 6.166
    Adamantane-linked isothiourea derivatives suppress the growth of experimental hepatocellular carcinoma via inhibition of TLR4-MyD88-NF-κB signaling

    PMID: 33575076

    		 Sample: Tissue homogenate(liver tissue),Serum
  26. BRAIN BEHAVIOR AND IMMUNITY (2019) IF: 6.17
    High mobility group box-1 mediates hippocampal inflammation and contributes to cognitive deficits in high-fat high-fructose diet-induced obese rats

    DOI: 10.1016/j.bbi.2019.08.007
    Sample: plasma，brain
  27. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021) IF: 6.291
    Bone marrow-derived mesenchymal stem cells attenuate silica-induced pulmonary fibrosis by inhibiting apoptosis and pyroptosis but not autophagy in rats

    DOI: 10.1016/j.ecoenv.2021.112181

    PMID: 33848736

    		 Sample: Cell sample,Tissue Slice
  28. INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023) IF: 6.51
    Therapeutic potential of cationic bilosomes in the treatment of carrageenan-induced rat arthritis via fluticasone propionate gel

    DOI: 10.1016/j.ijpharm.2023.122776
    Sample: joint
  29. Pharmaceutics (2023) IF: 6.525
    Immunomodulatory Effect of Novel Electrospun Nanofibers Loaded with Doxycycline as an Adjuvant Treatment in Periodontitis

    DOI: 10.3390/pharmaceutics15020707
    Sample: Blood
  30. BIOMEDICINE & PHARMACOTHERAPY (2020) IF: 6.53
    Tetramethylpyrazine attenuates endotoxin-induced retinal inflammation by inhibiting microglial activation via the TLR4/NF-κB signalling pathway

    DOI: 10.1016/j.biopha.2020.110273

    PMID: 32460188

    		 Sample: Cell culture supernatant
  31. BIOMEDICINE & PHARMACOTHERAPY (2021) IF: 6.53
    Omega-3 fatty acid rescues ischaemia/perfusion-induced testicular and sperm damage via modulation of lactate transport and xanthine oxidase/uric acid signaling

    DOI: 10.1016/j.biopha.2021.111975

    PMID: 34343894

    		 Sample: Testicular
  32. BIOMEDICINE & PHARMACOTHERAPY (2021) IF: 6.53
    MCC950 attenuates doxorubicin-induced myocardial injury in vivo and in vitro by inhibiting NLRP3-mediated pyroptosis

    DOI: 10.1016/j.biopha.2021.112133

    PMID: 34474337

    		 Sample: H9c2 cell
  33. BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 6.53
    Huangbai liniment and berberine promoted wound healing in high-fat diet/Streptozotocin-induced diabetic rats

    DOI: 10.1016/j.biopha.2022.112948

    PMID: 35430394

    		 Sample: skin tissue
  34. BIOMEDICINE & PHARMACOTHERAPY (2021) IF: 6.53
    Hippocampus kuda protein hydrolysate improves male reproductive dysfunction in diabetic rats

    DOI: 10.1016/j.biopha.2021.111760

    PMID: 34052566

    		 Sample: Tissue homogenate,Plasma
  35. BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 6.53
    Glutamine restores testicular glutathione-dependent antioxidant defense and upregulates NO/cGMP signaling in sleep deprivation-induced reproductive dysfunction in rats

    DOI: 10.1016/j.biopha.2022.112765

    PMID: 35247715

    		 Sample: Testicular,epididymal
  36. BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 6.53
    Glutamine prevents upregulation of NF-kB signaling and caspase 3 activation in ischaemia/reperfusion-induced testicular damage: An animal model

    DOI: 10.1016/j.biopha.2022.113056

    PMID: 35658227

    		 Sample: testicular tissue
  37. BIOMEDICINE & PHARMACOTHERAPY (2020) IF: 6.53
    Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role

    DOI: 10.1016/j.biopha.2020.110075

    PMID: 32179202

    		 Sample: Tissue homogenate
  38. BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 6.53
    Diacerein ameliorates letrozole-induced polycystic ovarian syndrome in rats

    DOI: 10.1016/j.biopha.2022.112870

    PMID: 35367769

    		 Sample: ovarian,serum
  39. Oxidative Medicine and Cellular Longevity (2016) IF: 6.543
    Thioredoxin-Interacting Protein Mediates NLRP3 Inflammasome Activation Involved in the Susceptibility to Ischemic Acute Kidney Injury in Diabetes

    DOI: 10.1155/2016/2386068
    Sample: Tissue homogenate
  40. Oxidative Medicine and Cellular Longevity (2022) IF: 6.543
    Ketone Body β-Hydroxybutyrate Prevents Myocardial Oxidative Stress in Septic Cardiomyopathy

    DOI: 10.1155/2022/2513837

    PMID: 35340211

    		 Sample: H9C2 Cell
  41. Frontiers in Nutrition (2022) IF: 6.576
    Comparative Analysis of the Bioactive Compounds in Chicken Cartilage: Protective Effects of Chondroitin Sulfate and Type II Collagen Peptides Against Osteoarthritis Involve Gut Microbiota

    DOI: 10.3389/fnut.2022.843360
    Sample: synovial fluid,serum
  42. Cells (2019) IF: 6.6
    Anti-Neuroinflammatory Effect of Alantolactone through the Suppression of the NF-κB and MAPK Signaling Pathways

    DOI: 10.3390/cells8070739
    Sample: PC12 cells
  43. PHYTOMEDICINE (2022) IF: 6.656
    Intragastric administration of Pien Tze Huang enhanced wound healing in diabetes by inhibiting inflammation and improving energy generation

    DOI: 10.1016/j.phymed.2022.154578
    Sample: skin tissue
  44. PHYTOMEDICINE (2022) IF: 6.656
    A discovery of clinically approved Panlongqi Tablet for repositioning to treat osteoarthritis by inhibiting PI3K/AKT activation

    DOI: 10.1016/j.phymed.2022.154360
    Sample: serum
  45. Frontiers in Cell and Developmental Biology (2021) IF: 6.684
    Emodin Prevented Depression in Chronic Unpredicted Mild Stress-Exposed Rats by Targeting miR-139-5p/5-Lipoxygenase

    DOI: 10.3389/fcell.2021.696619

    PMID: 34381778

    		 Sample: hippocampal
  46. Nutrients (2022) IF: 6.706
    Cornuside Is a Potential Agent against Alzheimer’s Disease via Orchestration of Reactive Astrocytes

    DOI: 10.3390/nu14153179
    Sample: C6 cell
  47. LIFE SCIENCES (2022) IF: 6.78
    Astragaloside IV ameliorates sepsis-induced myocardial dysfunction by regulating NOX4/JNK/BAX pathway

    DOI: 10.1016/j.lfs.2022.121123

    PMID: 36302499

    		 Sample: myocardium,serum
  48. BRITISH JOURNAL OF PHARMACOLOGY (2018) IF: 6.81
    High‐fructose corn syrup consumption in adolescent rats causes bipolar‐like behavioural phenotype with hyperexcitability in hippocampal CA3‐CA1 synapses

    DOI: 10.1111/bph.14500
    Sample: Serum
  49. Journal of Inflammation Research (2021) IF: 6.922
    Estrogen Protects Articular Cartilage by Downregulating ASIC1a in Rheumatoid Arthritis

    DOI: 10.2147/JIR.S295222
    Sample: serum
  50. Journal of Inflammation Research (2021) IF: 6.922
    Anti-Inflammatory Potentials of the n-Hexane Fraction of Alstonia boonei Stem Bark in Lipopolysaccharide-Induced Inflammation in Wistar Rats

    DOI: 10.2147/JIR.S304076
    Sample: serum
  51. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022) IF: 6.953
    Metabolites of gut microbiota fermenting Poria cocos polysaccharide alleviates chronic nonbacterial prostatitis in rats

    DOI: 10.1016/j.ijbiomac.2022.04.029

    PMID: 35398386

    		 Sample: prostate
  52. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021) IF: 6.953
    Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation

    DOI: 10.1016/j.ijbiomac.2021.05.066

    PMID: 33992651

    		 Sample: Tissue homogenate(Liver)
  53. Antioxidants (2020) IF: 5.014
    Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol

    DOI: 10.3390/antiox9010085

    PMID: 31963913

    		 Sample: Plasma
  54. LIFE SCIENCES (2021) IF: 5.037
    Protective effects of hesperidin through attenuation of Ki67 expression against DMBA-induced breast cancer in female rats

    DOI: 10.1016/j.lfs.2021.119957

    PMID: 34530017

    		 Sample: Breast tissue
  55. LIFE SCIENCES (2019) IF: 5.037
    Myocardial caspase-3 and NF-κB activation promotes calpain-induced septic apoptosis: The role of Akt/eNOS/NO pathway

    DOI: 10.1016/j.lfs.2019.02.048

    PMID: 30807754

    		 Sample: Serum,Tissue homogenate
  56. LIFE SCIENCES (2022) IF: 5.037
    Inosine attenuates 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats via the activation of the A2AR/BDNF/TrKB/ERK/CREB signaling pathway

    DOI: 10.1016/j.lfs.2022.120569

    PMID: 35472453

    		 Sample: Striatal
  57. LIFE SCIENCES (2021) IF: 5.037
    Effect of l-carnitine supplementation on lead acetate-induced liver cell apoptosis and inflammation: role of caspase-3 and glycogen synthase kinase-3β enzymes

    DOI: 10.1016/j.lfs.2021.120277

    PMID: 34979196

    		 Sample: liver
  58. LIFE SCIENCES (2021) IF: 5.037
    Arjunolic acid downregulates elevated blood sugar and pro-inflammatory cytokines in streptozotocin (STZ)-nicotinamide induced type 2 diabetic rats

    DOI: 10.1016/j.lfs.2021.120232

    PMID: 34919901

    		 Sample: serum,pancreatic tissue
  59. LIFE SCIENCES (2021) IF: 5.037
    Agomelatine prevents gentamicin nephrotoxicity by attenuating oxidative stress and TLR-4 signaling, and upregulating PPARγ and SIRT1

    DOI: 10.1016/j.lfs.2021.119600

    PMID: 33984362

    		 Sample: Serum
  60. Oxidative Medicine and Cellular Longevity (2020) IF: 5.076
    Neuregulin-1β Protects the Rat Diaphragm during Sepsis against Oxidative Stress and Inflammation by Activating the PI3K/Akt Pathway

    DOI: 10.1155/2020/1720961
    Sample: Serum,Tissue homogenate
  61. Oxidative Medicine and Cellular Longevity (2020) IF: 5.076
    Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia

    DOI: 10.1155/2020/2963540

    PMID: 33294118

    		 Sample: Cell culture medium
  62. Frontiers in Immunology (2020) IF: 5.085
    Corilagin Ameliorates Atherosclerosis in Peripheral Artery Disease via the Toll-Like Receptor-4 Signaling Pathway in vitro and in vivo

    DOI: 10.3389/fimmu.2020.01611
    Sample: plasma
  63. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017) IF: 5.104
    Bifidobacterium Infantis Ameliorates Chemotherapy-Induced Intestinal Mucositis Via Regulating T Cell Immunity in Colorectal Cancer Rats

    DOI: 10.1159/000480005
    Sample: Serum
  64. CHEMOSPHERE (2019) IF: 5.108
    Impact of binary waterborne mixtures of nickel and zinc on hypothalamic-pituitary-testicular axis in rats

    DOI: 10.1016/j.chemosphere.2019.124501

    PMID: 31398612

    		 Sample: Serum
  65. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022) IF: 5.112
    Thermosensitive smart hydrogel of PEITC ameliorates the therapeutic efficacy in rheumatoid arthritis

    DOI: 10.1016/j.ejps.2022.106367
    Sample: serum
  66. Aging-US (2018) IF: 5.179
    Methanolic extract of Tamarix Gallica attenuates hyperhomocysteinemia induced AD-like pathology and cognitive impairments in rats

    DOI: 10.18632/aging.101627

    PMID: 30425189

    		 Sample: Tissue homogenate
  67. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2023) IF: 5.19
    Betulinic acid protects against cardiotoxicity of the organophosphorus pesticide chlorpyrifos by suppressing oxidative stress, inflammation, and apoptosis in rats

    DOI: 10.1007/s11356-023-25917-6
    Sample: heart
  68. FASEB JOURNAL (2020) IF: 5.192
    Pre‐ischemic renal lavage protects against renal ischemia‐reperfusion injury by attenuation of local and systemic inflammatory responses

    DOI: 10.1096/fj.201902943R
    Sample: Plasma
  69. CHEMICO-BIOLOGICAL INTERACTIONS (2021) IF: 5.194
    Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro-inflammatory pathways and PPAR-γ/SIRT1 cytoprotective signals

    DOI: 10.1016/j.cbi.2021.109732

    PMID: 34737150

    		 Sample: serum
  70. JOURNAL OF ETHNOPHARMACOLOGY (2022) IF: 5.195
    Validation of traditional claims of anti-arthritic efficacy of trans-Himalayan snow mountain garlic (Allium ampeloprasum L.) extract using adjuvant-induced arthritis rat model: A comparative evaluation with normal garlic (Allium sativum L.) and dexamethas

    DOI: 10.1016/j.jep.2022.115939

    PMID: 36435406

    		 Sample: serum
  71. JOURNAL OF ETHNOPHARMACOLOGY (2022) IF: 5.195
    Exploring the anti-inflammatory potential of Colocasia esculenta root extract in in-vitro and in-vivo models of inflammation

    DOI: 10.1016/j.jep.2022.116021
    Sample: serum
  72. JOURNAL OF ETHNOPHARMACOLOGY (2022) IF: 5.195
    Evaluation of the in vitro and in vivo anti-inflammatory activity of Gymnosporia montana (Roth). Benth leaves

    DOI: 10.1016/j.jep.2022.115539

    PMID: 35843412

    		 Sample: RAW 264.7 cell
  73. Pharmaceuticals (2023) IF: 5.215
    Sorafenib Alleviates Inflammatory Signaling of Tumor Microenvironment in Precancerous Lung Injuries

    DOI: 10.3390/ph16020221
    Sample: lung tissue
  74. Pharmaceuticals (2022) IF: 5.215
    Azithromycin Mitigates Cisplatin-Induced Lung Oxidative Stress, Inflammation and Necroptosis by Upregulating SIRT1, PPARγ, and Nrf2/HO-1 Signaling

    DOI: 10.3390/ph16010052
    Sample: lungs
  75. CNS Neuroscience & Therapeutics (2022) IF: 5.243
    Transplantation of Roxadustat-preconditioned bone marrow stromal cells improves neurological function recovery through enhancing grafted cell survival in ischemic stroke rats

    DOI: 10.1111/cns.13890

    PMID: 35695696

    		 Sample: serum
  76. Frontiers in Molecular Biosciences (2021) IF: 5.246
    Folic Acid Alleviates High Glucose and Fat-Induced Pyroptosis via Inhibition of the Hippo Signal Pathway on H9C2 Cells

    DOI: 10.3389/fmolb.2021.698698

    PMID: 34692767

    		 Sample: H9C2 cell
  77. NEUROPHARMACOLOGY (2022) IF: 5.251
    Vortioxetine ameliorates motor and cognitive impairments in the rotenone-induced Parkinson's disease via targeting TLR-2 mediated neuroinflammation

    DOI: 10.1016/j.neuropharm.2022.108977

    PMID: 35092748

    		 Sample: hippocampus,PFC,striatum tissue
  78. BIOORGANIC CHEMISTRY (2021) IF: 5.275
    Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and mol

    DOI: 10.1016/j.bioorg.2021.105122
    Sample: serum
  79. Frontiers in Cellular and Infection Microbiology (2022) IF: 5.293
    Intestinal Epithelial Cell Exosome Launches IL-1β-Mediated Neuron Injury in Sepsis-Associated Encephalopathy

    DOI: 10.3389/fcimb.2021.783049

    PMID: 35111693

    		 Sample: serum,hippocampal tissue
  80. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021) IF: 5.31
    Oxidized high-density lipoprotein enhances endocrine disorders and ovarian damage in rats

    DOI: 10.1111/jcmm.16197

    PMID: 34346538

    		 Sample: granulosa cells (GCs)
  81. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021) IF: 5.31
    Normothermic machine perfusion attenuates hepatic ischaemia-reperfusion injury by inhibiting CIRP-mediated oxidative stress and mitochondrial fission

    DOI: 10.1111/jcmm.17062

    PMID: 34786826

    		 Sample: serum
  82. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022) IF: 5.31
    New insights into the central sympathetic hyperactivity post-myocardial infarction: Roles of METTL3-mediated m6A methylation

    DOI: 10.1111/jcmm.17183
    Sample: paraventricular nucleus(PVN) tissue
  83. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021) IF: 5.31
    Mesenchymal stem cells ameliorate silica-induced pulmonary fibrosis by inhibition of inflammation and epithelial-mesenchymal transition

    DOI: 10.1111/jcmm.16621

    PMID: 34076355

    		 Sample: lung,bronchoalveolar lavage fluid
  84. PHYTOMEDICINE (2021) IF: 5.34
    The piperine derivative HJ105 inhibits Aβ1-42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis

    DOI: 10.1016/j.phymed.2021.153571
    Sample: Tissue homogenate(hippocampus)
  85. PHYTOMEDICINE (2021) IF: 5.34
    Extracts of Poria cocos improve functional dyspepsia via regulating brain-gut peptides, immunity and repairing of gastrointestinal mucosa

    DOI: 10.1016/j.phymed.2021.153875

    PMID: 34911003

    		 Sample: serum
  86. PHYTOMEDICINE (2021) IF: 5.34
    Cardioprotective activity of ethyl acetate extract of Cinnamomi Ramulus against myocardial ischemia/reperfusion injury in rats via inhibiting NLRP3 inflammasome activation and pyroptosis

    DOI: 10.1016/j.phymed.2021.153798

    PMID: 34673348

    		 Sample: serum
  87. JOURNAL OF NEUROCHEMISTRY (2021) IF: 5.372
    Zinc induces reactive astrogliosis through ERK dependent activation of Stat3 and promotes synaptic degeneration

    DOI: 10.1111/jnc.15531
    Sample: primary astrocyte
  88. JOURNAL OF NEUROCHEMISTRY (2021) IF: 5.372
    Inhibiting Brd4 alleviated PTSD-like behaviors and fear memory through regulating immediate early genes expression and neuroinflammation in rats

    DOI: 10.1111/jnc.15439

    PMID: 34050937

    		 Sample: Tissue homogenate
  89. Food & Function (2022) IF: 5.396
    Asiatic acid from Cyclocarya paliurus regulates the autophagy–lysosome system via directly inhibiting TGF-β type I receptor and ameliorates diabetic nephropathy fibrosis

    DOI: 10.1039/D1FO02445K

    PMID: 35531774

    		 Sample: Urinary
  90. Chinese Medicine (2022) IF: 5.455
    Combination of pseudoephedrine and emodin ameliorates LPS-induced acute lung injury by regulating macrophage M1/M2 polarization through the VIP/cAMP/PKA pathway

    DOI: 10.1186/s13020-021-00562-8

    PMID: 35123524

    		 Sample: serum
  91. JOURNAL OF CELLULAR PHYSIOLOGY (2020) IF: 5.546
    Autophagy decreases alveolar epithelial cell injury by regulating the release of inflammatory mediators

    DOI: 10.1002/jcp.29453

    PMID: 31960959

    		 Sample: Cell culture supernatant,Tissue homogenate
  92. Nanomedicine-Nanotechnology Biology and Medicine (2019) IF: 5.57
    Delivery of siRNA using folate receptor-targeted pH-sensitive polymeric nanoparticles for rheumatoid arthritis therapy

    DOI: 10.1016/j.nano.2019.102017

    PMID: 31128293

    		 Sample: Plasma
  93. MOLECULAR NEUROBIOLOGY (2022) IF: 5.59
    Targeting the TLR4/NF-κΒ Axis and NLRP1/3 Inflammasomes by Rosuvastatin: A Role in Impeding Ovariectomy-Induced Cognitive Decline Neuropathology in Rats

    DOI: 10.1007/s12035-022-02852-0

    PMID: 35578102

    		 Sample: hippocampus
  94. ARTHRITIS RESEARCH & THERAPY (2022) IF: 5.606
    Targeting clock-controlled gene Nrf2 ameliorates inflammation-induced intervertebral disc degeneration

    DOI: 10.1186/s13075-022-02876-w

    PMID: 35922862

    		 Sample: NP cell
  95. EXPERIMENTAL NEUROLOGY (2022) IF: 5.62
    MicroRNA-140-5p shuttled by microglia-derived extracellular vesicles attenuates subarachnoid hemorrhage-induced microglia activation and inflammatory response via MMD downregulation

    DOI: 10.1016/j.expneurol.2022.114265
    Sample: brain
  96. Molecular Therapy-Nucleic Acids (2018) IF: 5.66
    miR-93-5p-Containing Exosomes Treatment Attenuates Acute Myocardial Infarction-Induced Myocardial Damage

    DOI: 10.1016/j.omtn.2018.01.010
    Sample: H9c2 cells
  97. Cell Communication and Signaling (2022) IF: 5.712
    Chlorogenic acid exerts neuroprotective effect against hypoxia-ischemia brain injury in neonatal rats by activating Sirt1 to regulate the Nrf2-NF-κB signaling pathway

    DOI: 10.1186/s12964-022-00860-0

    PMID: 35689269

    		 Sample: brain tissue
  98. ENVIRONMENTAL POLLUTION (2019) IF: 5.714
    Selenium abates reproductive dysfunction via attenuation of biometal accumulation, oxido-inflammatory stress and caspase-3 activation in male rats exposed to arsenic

    DOI: 10.1016/j.envpol.2019.113079

    PMID: 31473390

    		 Sample: Serum
  99. INTERNATIONAL IMMUNOPHARMACOLOGY (2023) IF: 5.714
    Escin alleviates stress-induced intestinal dysfunction to protect brain injury by regulating the gut-brain axis in ischemic stroke rats

    DOI: 10.1016/j.intimp.2022.109659
    Sample: plasma
  100. Frontiers in Aging Neuroscience (2021) IF: 5.75
    Enriched Environment Attenuates Pyroptosis to Improve Functional Recovery After Cerebral Ischemia/Reperfusion Injury

    DOI: 10.3389/fnagi.2021.717644

    PMID: 34646128

    		 Sample: penumbra tissue
  101. Journal of Neuroinflammation (2020) IF: 5.793
    Sodium para-aminosalicylic acid inhibits manganese-induced NLRP3 inflammasome-dependent pyroptosis by inhibiting NF-κB pathway activation and oxidative stress

    DOI: 10.1186/s12974-020-02018-6

    PMID: 33203418

    		 Sample: Tissue homogenate
  102. Frontiers in Pharmacology (2021) IF: 5.811
    β-Patchoulene Ameliorates Water Transport and the Mucus Barrier in 5-Fluorouracil-Induced Intestinal Mucositis Rats via the cAMP/PKA/CREB Signaling Pathway

    DOI: 10.3389/fphar.2021.689491
    Sample: Intestinal
  103. Frontiers in Pharmacology (2022) IF: 5.811
    Ursolic Acid Protects Neurons in Temporal Lobe Epilepsy and Cognitive Impairment by Repressing Inflammation and Oxidation.

    DOI: 10.3389/fphar.2022.877898
    Sample: hippocampal tissue
  104. Frontiers in Pharmacology (2021) IF: 5.811
    Sinapine Thiocyanate Ameliorates Vascular Endothelial Dysfunction in Hypertension by Inhibiting Activation of the NLRP3 Inflammasome

    DOI: 10.3389/fphar.2020.620159

    PMID: 33633569

    		 Sample: Serum
  105. Frontiers in Pharmacology (2022) IF: 5.811
    Naringin Interferes Doxorubicin-Induced Myocardial Injury by Promoting the Expression of ECHS1

    DOI: 10.3389/fphar.2022.859755

    PMID: 35496302

    		 Sample: H9C2 cell
  106. Translational Stroke Research (2019) IF: 5.847
    AAV/BBB-Mediated Gene Transfer of CHIP Attenuates Brain Injury Following Experimental Intracerebral Hemorrhage

    DOI: 10.1007/s12975-019-00715-w

    PMID: 31325153

    		 Sample: Plasma
  107. Bone & Joint Research (2021) IF: 5.853
    PARP-1 inhibition attenuates the inflammatory response in the cartilage of a rat model of osteoarthritis

    DOI: 10.1302/2046-3758.107.BJR-2020-0200.R2

    PMID: 34254815

    		 Sample: serum
  108. Pharmaceuticals (2022) IF: 5.863
    Xanthine Oxidase Inhibitor, Febuxostat Is Effective against 5-Fluorouracil-Induced Parotid Salivary Gland Injury in Rats Via Inhibition of Oxidative Stress, Inflammation and Targeting TRPC1/CHOP Signalling Pathway

    DOI: 10.3390/ph15020232
    Sample: parotid salivary gland
  109. Pharmaceuticals (2021) IF: 5.863
    Novel Mechanism for Memantine in Attenuating Diabetic Neuropathic Pain in Mice via Downregulating the Spinal HMGB1/TRL4/NF-kB Inflammatory Axis

    DOI: 10.3390/ph14040307
    Sample: spinal tissue
  110. INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021) IF: 5.875
    PLGA/PCADK composite microspheres containing hyaluronic acid–chitosan siRNA nanoparticles: A rational design for rheumatoid arthritis therapy

    DOI: 10.1016/j.ijpharm.2021.120204
    Sample: Serum
  111. Materials Science & Engineering C-Materials for Biological Applications (2020) IF: 5.88
    The sustained release of dexamethasone from TiO2 nanotubes reinforced by chitosan to enhance osteoblast function and anti-inflammation activity

    DOI: 10.1016/j.msec.2020.111241
    Sample: Cell culture supernatant
  112. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021) IF: 5.924
    Pantoprazole Attenuates MAPK (ERK1/2, JNK, p38)–NF-κB and Apoptosis Signaling Pathways after Renal Ischemia/Reperfusion Injury in Rats

    DOI: 10.3390/ijms221910669
    Sample: serum
  113. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021) IF: 4.013
    Nicotinamide mononucleotide attenuates doxorubicin-induced cardiotoxicity by reducing oxidative stress, inflammation and apoptosis in rats

    DOI: 10.1016/j.abb.2021.109050

    PMID: 34610336

    		 Sample: plasma, heart
  114. International Journal of Biological Sciences (2019) IF: 4.067
    Hydrogen sulfide treatment alleviated ventilator-induced lung injury through regulation of autophagy and endoplasmic reticulum stress

    DOI: 10.7150/ijbs.38315

    PMID: 31853224

    		 Sample: Serum,Bronchoalveolar Lavage Fluid,Tissue homogena
  115. BRAIN RESEARCH BULLETIN (2022) IF: 4.079
    Win55,212-2 Improves Neural Injury induced by HIV-1 Glycoprotein 120 in Rats by Exciting CB2R

    DOI: 10.1016/j.brainresbull.2022.02.006

    PMID: 35157986

    		 Sample: hippocampus
  116. JOURNAL OF CELLULAR PHYSIOLOGY (2017) IF: 4.08
    MSCs ameliorates DPN induced cellular pathology via [Ca2+]i homeostasis and scavenging the pro‐inflammatory cytokines

    DOI: 10.1002/jcp.26009
    Sample: neuronal cell
  117. BIOLOGICAL TRACE ELEMENT RESEARCH (2023) IF: 4.081
    Therapeutic Potential of Selenium Nanoparticles on Letrozole-Induced Polycystic Ovarian Syndrome in Female Wistar Rats

    DOI: 10.1007/s12011-023-03579-2
    Sample: Serum,ovarian cell
  118. INFLAMMATION (2021) IF: 4.092
    MiR-708-3p Alleviates Inflammation and Myocardial Injury After Myocardial Infarction by Suppressing ADAM17 Expression

    DOI: 10.1007/s10753-020-01404-9

    PMID: 33492555

    		 Sample: Tissue homogenate,Cell culture supernatant
  119. TOXICOLOGY (2020) IF: 4.099
    Protocatechuic acid modulates reproductive dysfunction linked to furan exposure in rats

    DOI: 10.1016/j.tox.2020.152556

    PMID: 32758512

    		 Sample: Serum,Tissue homogenate
  120. ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.109
    hUC-MSCs exosomal miR-451 alleviated acute lung injury by modulating macrophage M2 polarization via regulating MIF-PI3K-AKT signaling pathway

    DOI: 10.1002/tox.23639
    Sample: serum,NR8383 cell
  121. ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.119
    Platelet-rich plasma exhibits anti-inflammatory effect and attenuates cardiomyocyte damage by reducing NF-κB and enhancing VEGF expression in isoproterenol induced cardiotoxicity model

    DOI: 10.1002/tox.23456

    PMID: 35014750

    		 Sample: cardiac tissue
  122. ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.119
    LncRNA MEG3 ameliorates NiO nanoparticles-induced pulmonary inflammatory damage via suppressing the p38 mitogen activated protein kinases pathway

    DOI: 10.1002/tox.23464

    PMID: 35006638

    		 Sample: bronchoalveolar lavage fluid (BALF)
  123. ENVIRONMENTAL TOXICOLOGY (2021) IF: 4.119
    Limonin ameliorates acute pancreatitis by suppressing JAK2/STAT3 signaling pathway

    DOI: 10.1002/tox.23352

    PMID: 34423886

    		 Sample: serum
  124. ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.119
    Iron-induced cellular in vitro neurotoxic responses in rat C6 cell line

    DOI: 10.1002/tox.23543

    PMID: 35446454

    		 Sample: glioma C6 cell
  125. ENVIRONMENTAL TOXICOLOGY (2021) IF: 4.119
    Effects of 2,4-dichlorophenoxyacetic acid on the expression of NLRP3 inflammasome and autophagy-related proteins as well as the protective effect of Lycium barbarum polysaccharide in neonatal rats

    DOI: 10.1002/tox.23358

    PMID: 34464015

    		 Sample: serum
  126. ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.119
    2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide

    DOI: 10.1002/tox.23471

    PMID: 35099110

    		 Sample: serum
  127. Drug Design Development and Therapy (2021) IF: 4.162
    Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling

    DOI: 10.2147/DDDT.S325814

    PMID: 34764638

    		 Sample: blood
  128. TOXICOLOGY AND APPLIED PHARMACOLOGY (2021) IF: 4.219
    MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2

    DOI: 10.1016/j.taap.2021.115637

    PMID: 34217758

    		 Sample: serum
  129. Journal of Traditional and Complementary Medicine (2021) IF: 4.221
    Menhaden fish oil attenuates postpartum depression in rat model via inhibition of NLRP3-inflammasome driven inflammatory pathway

    DOI: 10.1016/j.jtcme.2021.02.007
    Sample: brain
  130. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022) IF: 4.223
    3-Indolepropionic acid prevented chlorpyrifos-induced hepatorenal toxicities in rats by improving anti-inflammatory, antioxidant, and pro-apoptotic responses and abating DNA damage

    DOI: 10.1007/s11356-022-21075-3

    PMID: 35644820

    		 Sample: Hepatic,renal
  131. Frontiers in Pharmacology (2020) IF: 4.225
    Inhibition of p38 MAPK Mitigates Lung Ischemia Reperfusion Injury by Reducing Blood–Air Barrier Hyperpermeability

    DOI: 10.3389/fphar.2020.569251
    Sample: Bronchoalveolar Lavage Fluid
  132. Journal of Clinical Medicine (2021) IF: 4.242
    Pharmacological Effects of Methotrexate and Infliximab in a Rats Model of Diet-Induced Dyslipidemia and Beta-3 Overexpression on Endothelial Cells

    DOI: 10.3390/jcm10143143

    PMID: 34300308

    		 Sample: plasma
  133. LABORATORY INVESTIGATION (2018) IF: 4.263
    The role of Ca 2+ in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis

    DOI: 10.1038/s41374-018-0135-3

    PMID: 30487596

    		 Sample: Plasma
  134. TOXICOLOGY LETTERS (2022) IF: 4.271
    Sodium para-aminosalicylic acid ameliorates brain neuroinflammation and behavioral deficits in juvenile lead-exposed rats by modulating MAPK signaling pathway and alpha-synuclein

    DOI: 10.1016/j.toxlet.2022.12.013
  135. Drug Design Development and Therapy (2022) IF: 4.319
    Alpha-Chymotrypsin Protects Against Acute Lung, Kidney, and Liver Injuries and Increases Survival in CLP-Induced Sepsis in Rats Through Inhibition of TLR4/NF-κB Pathway

    DOI: 10.2147/DDDT.S370460
    Sample: serum
  136. JOURNAL OF ETHNOPHARMACOLOGY (2021) IF: 4.36
    Role of Glutamine-Glutamate/GABA cycle and potential target GLUD2 in alleviation of rheumatoid arthritis by Tripterygium hypoglaucum (levl.) Hutch based on metabolomics and molecular pharmacology

    DOI: 10.1016/j.jep.2021.114561

    PMID: 34454056

    		 Sample: serum
  137. JOURNAL OF ETHNOPHARMACOLOGY (2022) IF: 4.36
    Network pharmacology analysis uncovers the effect on apoptotic pathway by Bu-Fei formula for COPD treatment

    DOI: 10.1016/j.jep.2022.115022

    PMID: 35074456

    		 Sample: bronchoalveolar lavage fluid (BALF)
  138. JOURNAL OF ETHNOPHARMACOLOGY (2022) IF: 4.36
    Nephroprotective mechanisms of Ambrette (Abelmoschus moschatus Medik.) leaf extracts in adriamycin mediated acute kidney injury model of Wistar rats

    DOI: 10.1016/j.jep.2022.115221

    PMID: 35339624

    		 Sample: Kidney
  139. JOURNAL OF ETHNOPHARMACOLOGY (2021) IF: 4.36
    Integrated serum pharmacochemistry and network pharmacological analysis used to explore possible anti-rheumatoid arthritis mechanisms of the Shentong-Zhuyu decoction

    DOI: 10.1016/j.jep.2021.113988

    PMID: 33667569

    		 Sample: Serum
  140. JOURNAL OF ETHNOPHARMACOLOGY (2021) IF: 4.36
    Arjunolic acid from Cyclocarya paliurus ameliorates diabetic retinopathy through AMPK/mTOR/HO-1 regulated autophagy pathway

    DOI: 10.1016/j.jep.2021.114772

    PMID: 34688801

    		 Sample: retinal tissue
  141. JOURNAL OF ETHNOPHARMACOLOGY (2021) IF: 4.36
    Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK signaling pathways

    DOI: 10.1016/j.jep.2021.114791

    PMID: 34737112

    		 Sample: serum
  142. JOURNAL OF ETHNOPHARMACOLOGY (2021) IF: 4.36
    Antidepressant-like effects of water extract of Cordyceps militaris (Linn.) Link by modulation of ROCK2/PTEN/Akt signaling in an unpredictable chronic mild stress-induced animal model

    DOI: 10.1016/j.jep.2021.114194

    PMID: 33974945

    		 Sample: Serum
  143. JOURNAL OF ETHNOPHARMACOLOGY (2021) IF: 4.36
    Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier

    DOI: 10.1016/j.jep.2021.114108

    PMID: 33839199

    		 Sample: Tissue homogenate
  144. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022) IF: 4.369
    BMSC-EVs overexpressing PD-L1 ameliorate DSS-induced ulcerative colitis in rats by regulating Th17/Treg cell balance through PTEN/PI3K/AKT/mTOR axis

    DOI: 10.1111/jgh.15987
    Sample: blood,colon
  145. Scientific Reports (2022) IF: 4.38
    Protective effect of ethanolic extract of Echinacea purpurea contained nanoparticles on meniscal/ligamentous injury induced osteoarthritis in obese male rats

    DOI: 10.1038/s41598-022-09380-w

    PMID: 35354886

    		 Sample: plasma
  146. Scientific Reports (2022) IF: 4.38
    Low-intensity low-frequency pulsed ultrasound ameliorates sciatic nerve dysfunction in a rat model of cisplatin-induced peripheral neuropathy

    DOI: 10.1038/s41598-022-11978-z

    PMID: 35581281

    		 Sample: serum
  147. Scientific Reports (2022) IF: 4.38
    Chondroitin and glucosamine sulphate reduced proinflammatory molecules in the DRG and improved axonal function of injured sciatic nerve of rats

    DOI: 10.1038/s41598-022-06554-4

    PMID: 35210446

    		 Sample: dorsal root ganglia
  148. MOLECULES (2022) IF: 4.412
    Vincamine Modulates the Effect of Pantoprazole in Renal Ischemia/Reperfusion Injury by Attenuating MAPK and Apoptosis Signaling Pathways

    DOI: 10.3390/molecules27041383

    PMID: 35209172

    		 Sample: serum
  149. MOLECULES (2022) IF: 4.412
    The Potential Antipyretic Mechanism of Ellagic Acid with Brain Metabolomics Using Rats with Yeast-Induced Fever

    DOI: 10.3390/molecules27082465

    PMID: 35458665

    		 Sample: serum
  150. MOLECULES (2022) IF: 4.412
    Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats

    DOI: 10.3390/molecules27061834

    PMID: 35335195

    		 Sample: hippocampus
  151. MOLECULES (2022) IF: 4.412
    Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism

    DOI: 10.3390/molecules27030889
    Sample: brain,blood plasma
  152. NEUROCHEMICAL RESEARCH (2022) IF: 4.414
    Sodium Para-aminosalicylic Acid Inhibits Lead-Induced Neuroinflammation in Brain Cortex of Rats by Modulating SIRT1/HMGB1/NF-κB Pathway

    DOI: 10.1007/s11064-022-03739-1

    PMID: 36063295

    		 Sample: primary cortical neurons
  153. JOURNAL OF PERIODONTAL RESEARCH (2021) IF: 4.419
    Periodontitis exacerbates the renal degenerative effects of obesity in rats

    DOI: 10.1111/jre.12919

    PMID: 34328646

    		 Sample: kidney
  154. JOURNAL OF PERIODONTAL RESEARCH (2021) IF: 4.419
    Influences of periodontitis on hippocampal inflammation, oxidative stress, and apoptosis in rats

    DOI: 10.1111/jre.12929

    PMID: 34486732

    		 Sample: hippocampus tissue
  155. EUROPEAN JOURNAL OF PHARMACOLOGY (2021) IF: 4.432
    Quercetin reduces inflammation in a rat model of diabetic peripheral neuropathy by regulating the TLR4/MyD88/NF-κB signalling pathway

    DOI: 10.1016/j.ejphar.2021.174607

    PMID: 34743981

    		 Sample: serum,sciatic nerves
  156. EUROPEAN JOURNAL OF PHARMACOLOGY (2019) IF: 4.432
    PSTPIP2 attenuates joint damage and suppresses inflammation in adjuvant-induced arthritis

    DOI: 10.1016/j.ejphar.2019.172558
    Sample: serum
  157. EUROPEAN JOURNAL OF PHARMACOLOGY (2022) IF: 4.432
    Piperazine ferulate protects against cardiac ischemia/reperfusion injury in rat via the suppression of NLRP3 inflammasome activation and pyroptosis

    DOI: 10.1016/j.ejphar.2022.174856

    PMID: 35219728

    		 Sample: serum
  158. INFLAMMOPHARMACOLOGY (2021) IF: 4.473
    The impact of Sambucus nigra L. extract on inflammation, oxidative stress and tissue remodeling in a rat model of lipopolysaccharide-induced subacute rhinosinusitis

    DOI: 10.1007/s10787-021-00805-y

    PMID: 33881685

    		 Sample: Serum
  159. CELL BIOLOGY INTERNATIONAL (2023) IF: 4.473
    TFEB attenuates hyperglycemia-induced retinal capillary endothelial cells injury via autophagy regulation

    DOI: 10.1002/cbin.12002
    Sample: serum
  160. INFLAMMOPHARMACOLOGY (2021) IF: 4.473
    Exploring the role of Aquaporins (AQPs) in LPS induced systemic inflammation and the ameliorative effect of Garcinia in male Wistar rat

    DOI: 10.1007/s10787-021-00832-9

    PMID: 34106384

    		 Sample: serum
  161. CELL BIOLOGY INTERNATIONAL (2023) IF: 4.473
    BML-111 inhibits osteoclast differentiation by suppressing the MAPK and NF-κB pathways, alleviating deterioration of the knee joints in a CIA rat model

    DOI: 10.1002/cbin.11990
    Sample: serum
  162. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018) IF: 4.491
    Dual-functional lipid polymeric hybrid pH-responsive nanoparticles decorated with cell penetrating peptide and folate for therapy against rheumatoid arthritis

    DOI: 10.1016/j.ejpb.2018.06.020
    Sample: Plasma
  163. JOURNAL OF CELLULAR PHYSIOLOGY (2019) IF: 4.522
    C1q/TNF‐related protein‐9 promotes macrophage polarization and improves cardiac dysfunction after myocardial infarction

    DOI: 10.1002/jcp.28513
    Sample: Tissue homogenate
  164. PSYCHOPHARMACOLOGY (2021) IF: 4.53
    Selenium abates manganese–induced striatal and hippocampal toxicity via abrogation of neurobehavioral deficits, biometal accumulation, oxidative stress, inflammation, and caspase-3 activation in rats

    DOI: 10.1007/s00213-021-06010-7
    Sample: striatum,hippocampus
  165. BIOMEDICINE & PHARMACOTHERAPY (2020) IF: 4.545
    Semen Brassicae reduces thoracic aortic remodeling, inflammation, and oxidative damage in spontaneously hypertensive rats

    DOI: 10.1016/j.biopha.2020.110400

    PMID: 32570115

    		 Sample: Serum
  166. BIOMEDICINE & PHARMACOTHERAPY (2020) IF: 4.545
    Huoxuezhitong capsule ameliorates MIA-induced osteoarthritis of rats through suppressing PI3K/ Akt/ NF-κB pathway

    DOI: 10.1016/j.biopha.2020.110471
    Sample: Serum
  167. BIOMEDICINE & PHARMACOTHERAPY (2020) IF: 4.545
    Effects of Atractylodes Oil on Inflammatory Response and Serum Metabolites in Adjuvant Arthritis Rats

    DOI: 10.1016/j.biopha.2020.110130
    Sample: serum
  168. BIOMEDICINE & PHARMACOTHERAPY (2020) IF: 4.545
    Diacerein protects rats with liver ischemia/reperfusion damage: Down-regulation of TLR4/ NFκ-B signaling pathway

    DOI: 10.1016/j.biopha.2020.111063

    PMID: 33348310

    		 Sample: Tissue homogenate
  169. BIOMEDICINE & PHARMACOTHERAPY (2020) IF: 4.545
    Berberine regulates fecal metabolites to ameliorate 5-fluorouracil induced intestinal mucositis through modulating gut microbiota

    DOI: 10.1016/j.biopha.2020.109829

    PMID: 31958765

    		 Sample: Tissue homogenate
  170. TOXICOLOGY (2022) IF: 4.571
    MicroRNA-223-3p promotes pyroptosis of cardiomyocyte and release of inflammasome factors via downregulating the expression level of SPI1 (PU.1)

    DOI: 10.1016/j.tox.2022.153252

    PMID: 35792203

    		 Sample: H9C2 cell
  171. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020) IF: 4.604
    Study of double-targeting nanoparticles loaded with MCL-1 siRNA and dexamethasone for adjuvant-induced arthritis therapy

    DOI: 10.1016/j.ejpb.2020.07.009

    PMID: 32681961

    		 Sample: Serum
  172. International Journal of Environmental Research and Public Health (2023) IF: 4.614
    Quercetin and Its Derivative Counteract Palmitate-Dependent Lipotoxicity by Inhibiting Oxidative Stress and Inflammation in Cardiomyocytes

    DOI: 10.3390/ijerph20043492
    Sample: H9c2 cardiomyocytes
  173. Journal of Inflammation Research (2022) IF: 4.631
    C/EBPβ Promotes LPS-Induced IL-1β Transcription and Secretion in Alveolar Macrophages via NOD2 Signaling

    DOI: 10.2147/JIR.S377499
    Sample: NR8383 cell
  174. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2016) IF: 4.652
    Hyperbaric Oxygen Intervention Modulates Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats: Possible Involvement of TLR4/NF-κ B-Mediated Signaling Pathway

    DOI: 10.1159/000445586
    Sample: Tissue homogenate
  175. INFLAMMATION (2022) IF: 4.657
    Inhibition of PD-1 Alters the SHP1/2-PI3K/Akt Axis to Decrease M1 Polarization of Alveolar Macrophages in Lung Ischemia–Reperfusion Injury

    DOI: 10.1007/s10753-022-01762-6
    Sample: lung tissue
  176. INFLAMMATION (2022) IF: 4.657
    Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study

    DOI: 10.1007/s10753-022-01763-5
    Sample: knee articular tissue
  177. Journal of the American Heart Association (2019) IF: 4.66
    CTRP9 Ameliorates Atrial Inflammation, Fibrosis, and Vulnerability to Atrial Fibrillation in Post‐Myocardial Infarction Rats

    DOI: 10.1161/JAHA.119.013133
    Sample: left atria
  178. Frontiers in Neuroscience (2021) IF: 4.677
    Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain

    DOI: 10.3389/fnins.2020.589650

    PMID: 33584172

    		 Sample: Plasma
  179. MEDIATORS OF INFLAMMATION (2020) IF: 4.711
    Exposure to Air Pollution Exacerbates Inflammation in Rats with Preexisting COPD

    DOI: 10.1155/2020/4260204

    PMID: 32454790

    		 Sample: Tissue homogenate,Bronchoalveolar Lavage Fluid
  180. Frontiers in Immunology (2019) IF: 4.716
    Naringenin Produces Neuroprotection Against LPS-Induced Dopamine Neurotoxicity via the Inhibition of Microglial NLRP3 Inflammasome Activation

    DOI: 10.3389/fimmu.2019.00936
    Sample: BV-2 cells
  181. Frontiers in Physiology (2023) IF: 4.755
    Effects of different simulated submarine escape depths by free ascent in animal models

    DOI: 10.3389/fphys.2023.1107782
    Sample: Serum
  182. Biomedicines (2022) IF: 4.757
    Effect of Celecoxib and Infliximab against Multiple Organ Damage Induced by Sepsis in Rats: A Comparative Study

    DOI: 10.3390/biomedicines10071613

    PMID: 35884918

    		 Sample: Serum
  183. JOURNAL OF PSYCHIATRIC RESEARCH (2021) IF: 4.791
    Fecal microbiota transplantation ameliorates stress-induced depression-like behaviors associated with the inhibition of glial and NLRP3 inflammasome in rat brain

    DOI: 10.1016/j.jpsychires.2021.02.057

    PMID: 33677218

    		 Sample: cortex,hippocampus
  184. Aging-US (2020) IF: 4.831
    Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis

    DOI: 10.18632/aging.103215

    PMID: 32432571

    		 Sample: Cell culture supernatant,Tissue homogenate
  185. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2021) IF: 4.86
    N-acetyl cysteine abates hepatorenal toxicities induced by perfluorooctanoic acid exposure in male rats

    DOI: 10.1016/j.etap.2021.103667

    PMID: 33933708

    		 Sample: Serum,Tissue homogenate
  186. Oxidative Medicine and Cellular Longevity (2019) IF: 4.868
    Mangiferin Attenuates Myocardial Ischemia-Reperfusion Injury via MAPK/Nrf-2/HO-1/NF-κB In Vitro and In Vivo

    DOI: 10.1155/2019/7285434
    Sample: serum,LV(left ventricular) myocardium,H9c2 cells
  187. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016) IF: 4.874
    Cinnamaldehyde ameliorates LPS-induced cardiac dysfunction via TLR4-NOX4 pathway: The regulation of autophagy and ROS production

    DOI: 10.1016/j.yjmcc.2016.10.017
    Sample: Serum
  188. MOLECULES (2022) IF: 4.927
    Effect of Natural Adenylcyclase/cAMP/CREB Signalling Activator Forskolin against Intra-Striatal 6-OHDA-Lesioned Parkinson’s Rats: Preventing Mitochondrial, Motor and Histopathological Defects

    DOI: 10.3390/molecules27227951
    Sample: brain
  189. MOLECULES (2022) IF: 4.927
    7-Hydroxyflavone Alleviates Myocardial Ischemia/Reperfusion Injury in Rats by Regulating Inflammation

    DOI: 10.3390/molecules27175371

    PMID: 36080137

    		 Sample: serum
  190. INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
    Protective effect of mirtazapine against acetic acid-induced ulcerative colitis in rats: Role of NLRP3 inflammasome pathway

    DOI: 10.1016/j.intimp.2021.108174

    PMID: 34601335

    		 Sample: colonic tissue
  191. INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
    Pinocembrin inhibited cardiomyocyte pyroptosis against doxorubicin-induced cardiac dysfunction via regulating Nrf2/Sirt3 signaling pathway

    DOI: 10.1016/j.intimp.2021.107533

    PMID: 33752080

    		 Sample: Serum,Cell culture supernatant
  192. INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
    Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway

    DOI: 10.1016/j.intimp.2021.107505

    PMID: 33725636

    		 Sample: serum,Cell culture supernatant(THP-1 cells)
  193. INTERNATIONAL IMMUNOPHARMACOLOGY (2019) IF: 4.932
    Apigenin attenuates acrylonitrile-induced neuro-inflammation in rats: Involved of inactivation of the TLR4/NF-κB signaling pathway

    DOI: 10.1016/j.intimp.2019.105697
    Sample: brain
  194. INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
    25-Hydroxycholesterol mitigates hepatic ischemia reperfusion injury via mediating mitophagy

    DOI: 10.1016/j.intimp.2021.107643

    PMID: 33878616

    		 Sample: Serum
  195. Journal of Inflammation Research (2020) IF: 4.953
    Pharmacological Inhibition of Galectin-3 Ameliorates Diabetes-Associated Cognitive Impairment, Oxidative Stress and Neuroinflammation in vivo and in vitro

    DOI: 10.2147/JIR.S273858

    PMID: 32982368

    		 Sample: Cell culture supernatant,Tissue homogenate
  196. Journal of Clinical Medicine (2022) IF: 4.964
    Moderate Aerobic Exercise Regulates Follicular Dysfunction by Initiating Brain-Derived Neurotrophic Factor (BDNF)-Mediated Anti-Apoptotic Signaling Pathways in Polycystic Ovary Syndrome

    DOI: 10.3390/jcm11195584

    PMID: 36233452

    		 Sample: serum
  197. FASEB JOURNAL (2020) IF: 4.966
    TGR5 receptor activation attenuates diabetic retinopathy through suppression of RhoA/ROCK signaling

    DOI: 10.1096/fj.201902496RR
    Sample: retinas
  198. Scientific Reports (2022) IF: 4.996
    Immunomodulatory activity of extracts from five edible basidiomycetes mushrooms in Wistar albino rats

    DOI: 10.1038/s41598-022-16349-2

    PMID: 35859110

    		 Sample: serum
  199. PLANTA MEDICA (2022) IF: 3.007
    Curative effect and mechanisms of Radix Arnebiae oil on burn wound healing in rats

    DOI: 10.1055/a-1997-5566
    Sample: burn wound tissue
  200. European Review for Medical and Pharmacological Sciences (2020) IF: 3.024
    Ulinastatin reduces myocardial injury induced by doxorubicin in SD rats.

    DOI: 10.26355/eurrev_202010_23437
    Sample: Serum
  201. European Review for Medical and Pharmacological Sciences (2020) IF: 3.024
    The effect of myocardial infarction-associated transcript 2 (Mirt2) and miR-101 on sepsis-induced myocardial injury in rats.

    DOI: 10.26355/eurrev_202006_21528
    Sample: Serum
  202. European Review for Medical and Pharmacological Sciences (2020) IF: 3.024
    Overexpression of HOXA-AS2 inhibits inflammation and apoptosis in podocytes via sponging miRNA-302b-3p to upregulate TIMP3

    DOI: 10.26355/eurrev_202005_21187
    Sample: Serum
  203. European Review for Medical and Pharmacological Sciences (2020) IF: 3.024
    Curcumin exerts protective effect on PC12 cells against lidocaine-induced cytotoxicity by suppressing the formation of NLRP3 inflammasome.

    DOI: 10.26355/eurrev_202006_21703
    Sample: Cell culture supernatant
  204. TOXICON (2022) IF: 3.033
    Caffeic acid protects against DNA damage, oxidative and inflammatory mediated toxicities, and upregulated caspases activation in the hepatorenal system of rats treated with aflatoxin B1

    DOI: 10.1016/j.toxicon.2021.12.021

    PMID: 34995555

    		 Sample: liver,kidney
  205. Journal of Diabetes Research (2019) IF: 3.04
    Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes

    DOI: 10.1155/2019/8151836
    Sample: Cell culture supernatant
  206. NEUROSCIENCE LETTERS (2020) IF: 3.046
    The novel estrogen receptor GPER1 decreases epilepsy severity and susceptivity in the hippocampus after status epilepticus

    DOI: 10.1016/j.neulet.2020.134978
    Sample: Hippocampus
  207. NEUROSCIENCE LETTERS (2022) IF: 3.046
    Participation of transient receptor potential vanilloid 1 in the analgesic effect of duloxetine for paclitaxel induced peripheral neuropathic pain

    DOI: 10.1016/j.neulet.2022.136512

    PMID: 35149198

    		 Sample: spinal cord
  208. RSC Advances (2019) IF: 3.049
    Morroniside alleviates coxsackievirus B3-induced myocardial damage apoptosis via restraining NLRP3 inflammasome activation

    DOI: 10.1039/C8RA08662A
    Sample: Tissue homogenate
  209. JOURNAL OF CHEMICAL NEUROANATOMY (2021) IF: 3.052
    DUSP1 regulates hippocampal damage in epilepsy rats via ERK1/2 pathway

    DOI: 10.1016/j.jchemneu.2021.102032

    PMID: 34562585

    		 Sample: Hippocampal tissue
  210. JOURNAL OF ETHNOPHARMACOLOGY (2016) IF: 3.055
    Venenum Bufonis induces rat neuroinflammation by activiating NF-κB pathway and attenuation of BDNF

    DOI: 10.1016/j.jep.2016.03.049
    Sample: Tissue homogenate
  211. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2020) IF: 3.056
    Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-κB-p65/NLRP-3 and JAK1/STAT-3 signaling pathways

    DOI: 10.1007/s11356-020-11416-5

    PMID: 33128149

    		 Sample: Serum
  212. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2020) IF: 3.056
    Platelet-rich plasma and/or sildenafil topical applications accelerate and better repair wound healing in rats through regulation of proinflammatory cytokines and collagen/TGF-β1 pathway

    DOI: 10.1007/s11356-020-10042-5

    PMID: 32671702

    		 Sample: Serum
  213. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2020) IF: 3.056
    Aged garlic extract rescues ethephon-induced kidney damage by modulating oxidative stress, apoptosis, inflammation, and histopathological changes in rats

    DOI: 10.1007/s11356-020-10997-5

    PMID: 33011947

    		 Sample: Serum
  214. MOLECULES (2019) IF: 3.06
    Plant-Derived Oleanolic Acid (OA) Ameliorates Risk Factors of Cardiovascular Diseases in a Diet-Induced Pre-Diabetic Rat Model: Effects on Selected Cardiovascular Risk Factors

    DOI: 10.3390/molecules24020340

    PMID: 30669379

    		 Sample: Plasma,Tissue homogenate
  215. MOLECULES (2019) IF: 3.06
    Hyaluronic Acid Coated Acid-Sensitive Nanoparticles for Targeted Therapy of Adjuvant-Induced Arthritis in Rats

    DOI: 10.3390/molecules24010146

    PMID: 30609724

    		 Sample: Serum
  216. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2019) IF: 3.061
    Neurobehavioural and biochemical responses associated with exposure to binary waterborne mixtures of zinc and nickel in rats

    DOI: 10.1016/j.etap.2019.103294
    Sample: cerebellum,cerebrum,liver
  217. Food Bioscience (2020) IF: 3.067
    Curcumin combined with Baicalin attenuated ethanol-induced hepatitis by suppressing p38 MAPK and TSC1/ eIF-2α/ATF4 pathways in rats

    DOI: 10.1016/j.fbio.2020.100851
    Sample: liver tissue lysate
  218. PROSTAGLANDINS & OTHER LIPID MEDIATORS (2021) IF: 3.072
    Anti-inflammatory activity of 2-((3-(chloromethyl)benzoyl)oxy)benzoic acid in LPS-induced rat model

    DOI: 10.1016/j.prostaglandins.2021.106549

    PMID: 33831580

    		 Sample: Plasma
  219. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2019) IF: 3.091
    Nisin reduces uterine inflammation in rats by modulating concentrations of pro‐ and anti‐inflammatory cytokines

    DOI: 10.1111/aji.13096
    Sample: Serum
  220. PHYTOTHERAPY RESEARCH (2017) IF: 3.092
    Scopoletin‐standardized Morinda elliptica leaf extract suppressed inflammation and cartilage degradation to alleviate osteoarthritis: A preclinical study

    DOI: 10.1002/ptr.5949
    Sample: Serum
  221. RSC Advances (2017) IF: 3.108
    Holistic and dynamic metabolic alterations of traditional Chinese medicine syndrome in a toxic heat and blood stasis syndrome rat model

    DOI: 10.1039/C7RA11748E
    Sample: plasma
  222. Frontiers in Bioscience-Landmark (2023) IF: 3.115
    β-arrestin2 Mediates the Arginine Vasopressin-Induced Expression of IL-1β in Murine Hearts

    DOI: 10.31083/j.fbl2801007
    Sample: Adult rat cardiac fibroblasts (ARCFs)
  223. EXPERIMENTAL BIOLOGY AND MEDICINE (2020) IF: 3.139
    H2S attenuates oxidative stress via Nrf2/NF-κB signaling to regulate restenosis after percutaneous transluminal angioplasty:

    DOI: 10.1177/1535370220961038
    Sample: Plasma
  224. REPRODUCTIVE TOXICOLOGY (2022) IF: 3.143
    Codeine alters female reproductive function by targeting ovarian steroidogenesis and folliculogenesis via the induction of oxidative stress, inflammation, and apoptosis

    DOI: 10.1016/j.reprotox.2022.02.001

    PMID: 35158039

    		 Sample: serum
  225. IMMUNOBIOLOGY (2023) IF: 3.152
    STING mediates SU5416/hypoxia-induced pulmonary arterial hypertension in rats by regulating macrophage NLRP3 inflammasome activation

    DOI: 10.1016/j.imbio.2023.152345
    Sample: lung tissues,Bone marrow-derived macrophage (BMDMs
  226. Mycotoxin Research (2020) IF: 3.164
    Acute aflatoxin B 1 -induced gastro-duodenal and hepatic oxidative damage is preceded by time-dependent hyperlactatemia in rats

    DOI: 10.1007/s12550-020-00408-6
    Sample: Serum
  227. EUROPEAN JOURNAL OF PHARMACOLOGY (2019) IF: 3.17
    Associations of inflammatory markers and vascular cell adhesion molecule-1 with endothelial dysfunction in collagen-induced arthritis

    DOI: 10.1016/j.ejphar.2019.172786

    PMID: 31712060

    		 Sample: Serum
  228. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2017) IF: 3.176
    Small Molecule Inhibiting Nuclear Factor‐kB Ameliorates Oxidative Stress and Suppresses Renal Inflammation in Early Stage of Alloxan‐Induced Diabetic Nephropathy in Rat

    DOI: 10.1111/bcpt.12718
    Sample: Tissue homogenate
  229. NEUROSCIENCE LETTERS (2022) IF: 3.197
    Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation

    DOI: 10.1016/j.neulet.2022.136787

    PMID: 35820551

    		 Sample: serum
  230. Drug Design Development and Therapy (2020) IF: 3.216
    Hirudin Protects Against Kidney Damage in Streptozotocin-Induced Diabetic Nephropathy Rats by Inhibiting Inflammation via P38 MAPK/NF-κB Pathway

    DOI: 10.2147/DDDT.S257613

    PMID: 32848363

    		 Sample: Cell culture supernatant,Tissue homogenate
  231. PLoS One (2015) IF: 3.234
    Transplantation of Induced Pluripotent Stem Cells Alleviates Cerebral Inflammation and Neural Damage in Hemorrhagic Stroke

    DOI: 10.1371/journal.pone.0129881
    Sample: Tissue homogenate
  232. PLoS One (2015) IF: 3.234
    Osteoprotective Effect of Echinocystic Acid, a Triterpone Component from Eclipta prostrata, in Ovariectomy-Induced Osteoporotic Rats

    DOI: 10.1371/journal.pone.0136572
    Sample: Serum
  233. PLoS One (2015) IF: 3.234
    Extracellular Vesicles Derived from Bone Marrow Mesenchymal Stem Cells Protect against Experimental Colitis via Attenuating Colon Inflammation, Oxidative Stress and Apoptosis

    DOI: 10.1371/journal.pone.0140551
    Sample: Tissue homogenate
  234. MOLECULAR IMMUNOLOGY (2017) IF: 3.236
    The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways

    DOI: 10.1016/j.molimm.2017.12.008
    Sample: Bronchoalveolar Lavage Fluid,Serum,Tissue homogena
  235. Biomed Research International (2022) IF: 3.246
    Lagerstroemia speciosa Ameliorated Blood Pressure in LNAME Induced Hypertension in Experimental Rats through NO/cGMP and Oxidative Stress Modulation

    DOI: 10.1155/2022/5894416
    Sample: heart tissue
  236. HUMAN & EXPERIMENTAL TOXICOLOGY (2023) IF: 3.247
    The IL-6/HO-1/STAT3 signaling pathway is implicated in the amelioration of acetaminophen-induced hepatic toxicity: A neonatal rat model

    DOI: 10.1177/09603271231151376
    Sample: hepatic
  237. Life-Basel (2023) IF: 3.251
    Ferulic Acid Treats Gastric Ulcer via Suppressing Oxidative Stress and Inflammation

    DOI: 10.3390/life13020388
    Sample: gastric tissue
  238. JOURNAL OF GENE MEDICINE (2020) IF: 3.258
    Celastrol mitigates high glucose‐induced inflammation and apoptosis in rat H9c2 cardiomyocytes via miR‐345‐5p/growth arrest‐specific 6

    DOI: 10.1002/jgm.3201
    Sample: H9c2 cell
  239. NEUROTOXICOLOGY (2019) IF: 3.263
    Neuroprotective mechanisms of selenium against arsenic-induced behavioral impairments in rats

    DOI: 10.1016/j.neuro.2019.10.009

    PMID: 31678059

    		 Sample: Tissue homogenate
  240. NEUROTOXICOLOGY (2019) IF: 3.263
    Neuroprotection by luteolin and gallic acid against cobalt chloride-induced behavioural, morphological and neurochemical alterations in Wistar rats

    DOI: 10.1016/j.neuro.2019.07.005
    Sample: serum
  241. EUROPEAN JOURNAL OF PHARMACOLOGY (2020) IF: 3.263
    Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation

    DOI: 10.1016/j.ejphar.2020.173734

    PMID: 33220272

    		 Sample: Tissue homogenate(Hippocampal tissues)
  242. American Journal of Translational Research (2019) IF: 3.266
    Protective effects of Ulinastatin on oxidative stress and inflammation of rat-derived cardiomyocytes H9c2

    PMID: 31814912

    		 Sample: H9c2 cells
  243. Bioengineered (2021) IF: 3.269
    Dehydroevodiamine Suppresses Inflammatory Responses in Adjuvant-Induced Arthritis Rats and Human Fibroblast-Like Synoviocytes

    DOI: 10.1080/21655979.2021.1999554

    PMID: 34719315

    		 Sample: serum,MH7A cells
  244. IMMUNOLOGY LETTERS (2020) IF: 3.276
    Protective effect of Ganoderic acid A on adjuvant-induced arthritis

    DOI: 10.1016/j.imlet.2020.06.010

    PMID: 32565114

    		 Sample: Serum
  245. BMC NEUROSCIENCE (2021) IF: 3.288
    Metformin attenuates sepsis-induced neuronal injury and cognitive impairment

    DOI: 10.1186/s12868-021-00683-8

    PMID: 34911449

    		 Sample: hippocampus tissue
  246. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2020) IF: 3.292
    Nicotine-mediated upregulation of microRNA-141 expression determines adipokine-intervened insulin resistance

    DOI: 10.1016/j.etap.2020.103506

    PMID: 33002592

    		 Sample: Serum
  247. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018) IF: 3.293
    Inhibition of endoplasmic reticulum stress by 4-phenylbutyric acid prevents vital organ injury in rat acute pancreatitis

    DOI: 10.1152/ajpgi.00102.2018

    PMID: 30138574

    		 Sample: Serum
  248. Annals of Translational Medicine (2020) IF: 3.297
    Palmitic acid stimulates NLRP3 inflammasome activation through TLR4-NF-κB signal pathway in hepatic stellate cells

    DOI: 10.21037/atm.2020.02.21

    PMID: 32309315

    		 Sample: Serum,Cell culture supernatant,Tissue homogenate
  249. INFLAMMOPHARMACOLOGY (2018) IF: 3.304
    SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy

    DOI: 10.1007/s10787-018-0522-9

    PMID: 30094758

    		 Sample: Tissue homogenate
  250. INFLAMMOPHARMACOLOGY (2018) IF: 3.304
    prevented osteoarthritis cartilage degeneration by attenuating joint inflammation and collagen breakdown in postmenopausal rat model

    DOI: 10.1007/s10787-018-0452-6
    Sample: serum
  251. INFLAMMOPHARMACOLOGY (2018) IF: 3.304
    ) protected against osteoarthritis by mitigating inflammation and cartilage degradation: a preclinical study

    DOI: 10.1007/s10787-017-0432-2
    Sample: serum
  252. Journal of Tissue Engineering and Regenerative Medicine (2019) IF: 3.319
    Nanostructured fibrin agarose hydrogel as a novel haemostatic agent

    DOI: 10.1002/term.2831
    Sample: Plasma
  253. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2023) IF: 3.322
    Acupuncture exerts preventive effects in rats of chronic unpredictable mild stress: The involvement of inflammation in amygdala and brain-spleen axis

    DOI: 10.1016/j.bbrc.2023.01.046
    Sample: Serum,amygdala
  254. BRITISH JOURNAL OF NUTRITION (2020) IF: 3.334
    Impact of improving eating habits and rosmarinic acid supplementation on rat vascular and neuronal system in the metabolic syndrome model

    DOI: 10.1017/S000711452000327X

    PMID: 32814604

    		 Sample: Serum
  255. TOXICOLOGY AND APPLIED PHARMACOLOGY (2020) IF: 3.347
    Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment

    DOI: 10.1016/j.taap.2020.115380

    PMID: 33358696

    		 Sample: Tissue homogenate
  256. DRUG AND CHEMICAL TOXICOLOGY (2021) IF: 3.356
    Rupatadine protects the intestinal mucosa from injury by 5-flurouracil via modulation of inflammation, apoptosis and intestinal permeability

    DOI: 10.1080/01480545.2021.1997541

    PMID: 34747284

    		 Sample: intestinal
  257. INTERNATIONAL IMMUNOPHARMACOLOGY (2019) IF: 3.361
    The ameliorating effect of cannabinoid type 2 receptor activation on brain, lung, liver and heart damage in cecal ligation and puncture-induced sepsis model in rats

    DOI: 10.1016/j.intimp.2019.105978

    PMID: 31767546

    		 Sample: Tissue homogenate
  258. INTERNATIONAL IMMUNOPHARMACOLOGY (2019) IF: 3.361
    Inhibition of macrophage migration inhibitory factor attenuates inflammation and fetal kidney injury in a rat model of acute pancreatitis in pregnancy

    DOI: 10.1016/j.intimp.2018.12.068

    PMID: 30622028

    		 Sample: Serum
  259. Frontiers in Physiology (2020) IF: 3.367
    Effect of Clostridium butyricum and Butyrate on Intestinal Barrier Functions: Study of a Rat Model of Severe Acute Pancreatitis With Intra-Abdominal Hypertension

    DOI: 10.3389/fphys.2020.561061

    PMID: 33192557

    		 Sample: Plasma
  260. BRAIN RESEARCH BULLETIN (2020) IF: 3.37
    Mechanism of TREM2/DAP12 complex affecting β-amyloid plaque deposition in Alzheimer's disease modeled mice through mediating inflammatory response

    DOI: 10.1016/j.brainresbull.2020.10.006

    PMID: 33053435

    		 Sample: Tissue homogenate
  261. Molecular Pain (2022) IF: 3.37
    CXCR1 participates in bone cancer pain induced by Walker 256 breast cancer cells in female rats

    DOI: 10.1177/17448069221135743

    PMID: 36227008

    		 Sample: spinal cord tissues
  262. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2021) IF: 3.377
    Metformin ameliorates bladder dysfunction in a rat model of partial bladder outlet obstruction

    DOI: 10.1152/ajprenal.00625.2020

    PMID: 33645317

    		 Sample: Tissue homogenate(Bladder)
  263. JOURNAL OF BIOCHEMISTRY (2021) IF: 3.387
    Lidocaine activates autophagy of astrocytes and ameliorates chronic constriction injury-induced neuropathic pain

    DOI: 10.1093/jb/mvaa136
    Sample: astrocyte
  264. Biomed Research International (2021) IF: 3.411
    Celastrol Attenuates Learning and Memory Deficits in an Alzheimer’s Disease Rat Model

    DOI: 10.1155/2021/5574207
    Sample: brain
  265. CONNECTIVE TISSUE RESEARCH (2021) IF: 3.417
    Evaluation of cytokines in protective effect of docosahexaenoic acid in experimental achilles tendinopathy rat model induced with type-1 collagenase

    DOI: 10.1080/03008207.2021.1982915

    PMID: 34612118

    		 Sample: serum
  266. Molecular Medicine Reports (2022) IF: 3.423
    Adipose‑derived mesenchymal stem cell‑derived HCAR1 regulates immune response in the attenuation of sepsis

    DOI: 10.3892/mmr.2022.12795

    PMID: 35856408

    		 Sample: blood
  267. DISEASE MARKERS (2022) IF: 3.434
    Knockdown of ILK Alleviates High Glucose-Induced Damage of H9C2 Cells through TLR4/MyD88/NF-κB Pathway

    DOI: 10.1155/2022/6205190
    Sample: H9C2 cell
  268. JOURNAL OF CELLULAR BIOCHEMISTRY (2019) IF: 3.448
    Tao‐Hong‐Si‐Wu decoction reduces ischemia reperfusion rat myoblast cells calcium overloading and inflammation through the Wnt/IP3R/CAMKII pathway

    DOI: 10.1002/jcb.28582
    Sample: Cell culture supernate
  269. LIFE SCIENCES (2019) IF: 3.448
    Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats

    DOI: 10.1016/j.lfs.2019.117217
    Sample: kidney
  270. JOURNAL OF CELLULAR BIOCHEMISTRY (2019) IF: 3.448
    Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study

    DOI: 10.1002/jcb.28976

    PMID: 31099131

    		 Sample: Tissue homogenate
  271. BIOMEDICINE & PHARMACOTHERAPY (2018) IF: 3.457
    Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity

    DOI: 10.1016/j.biopha.2018.07.081
    Sample: Serum
  272. BIOMEDICINE & PHARMACOTHERAPY (2018) IF: 3.457
    Down-regulation of microRNA-21 reduces inflammation and podocyte apoptosis in diabetic nephropathy by relieving the repression of TIMP3 expression

    DOI: 10.1016/j.biopha.2018.09.007
    Sample: serum
  273. EXPERIMENTAL EYE RESEARCH (2022) IF: 3.467
    A modified high-yield method for primary culture of rat retinal microglial cells

    DOI: 10.1016/j.exer.2021.108919

    PMID: 34979098

    		 Sample: microglial cell
  274. JOURNAL OF NEUROIMMUNOLOGY (2022) IF: 3.478
    Activation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal rats

    DOI: 10.1016/j.jneuroim.2022.577894

    PMID: 35642994

    		 Sample: Brain tissue
  275. PHARMACEUTICAL BIOLOGY (2021) IF: 3.503
    Guizhi-Shaoyao-Zhimu decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF‐κB signalling to suppress osteoclastogenesis

    DOI: 10.1080/13880209.2021.1876100
    Sample: serum
  276. European Review for Medical and Pharmacological Sciences (2019) IF: 3.507
    Influence of lncRNA HOTAIR on acute kidney injury in sepsis rats through regulating miR-34a/Bcl-2 pathway.

    DOI: 10.26355/eurrev_201904_17717
    Sample: kidney tissues
  277. Journal of Personalized Medicine (2023) IF: 3.508
    Effect of Hydrogen on AM Pyroptosis Induced by Severe Burns in Rats

    DOI: 10.3390/jpm13030377
    Sample: lung tissues
  278. Oxidative Medicine and Cellular Longevity (2015) IF: 3.516
    Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator

    DOI: 10.1155/2015/965961
    Sample: Serum
  279. Toxicology Research (2021) IF: 3.524
    The modulatory effect of taurine on benzo (a) pyrene-induced hepatorenal toxicity

    DOI: 10.1093/toxres/tfab016

    PMID: 34141152

    		 Sample: serum
  280. Toxicology Research (2021) IF: 3.524
    Chlorogenic acid abates oxido-inflammatory and apoptotic responses in the liver and kidney of Tamoxifen-treated rats

    DOI: 10.1093/toxres/tfab002
    Sample: hepatic,renal
  281. MEDIATORS OF INFLAMMATION (2019) IF: 3.545
    High-Fat Diet Aggravates the Intestinal Barrier Injury via TLR4-RIP3 Pathway in a Rat Model of Severe Acute Pancreatitis

    DOI: 10.1155/2019/2512687
    Sample: serum
  282. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2022) IF: 3.568
    Exposure of aluminium to C6 glioma cells modulates molecular and functional neurotoxic markers

    DOI: 10.1002/jbt.23210

    PMID: 36056780

    		 Sample: C6 cell
  283. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2023) IF: 3.568
    Exploring the cardioprotective effects of canagliflozin against cisplatin-induced cardiotoxicity: Role of iNOS/NF-κB, Nrf2, and Bax/cytochrome C/Bcl-2 signals

    DOI: 10.1002/jbt.23309
    Sample: Cardiac
  284. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2022) IF: 3.568
    Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study

    DOI: 10.1002/jbt.23240
    Sample: blood
  285. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022) IF: 3.575
    Sulforaphane protects myocardium from ischemia-reperfusion injury by regulating CaMKIIN2 and CaMKIIδ

    DOI: 10.1016/j.bbrc.2022.03.015

    PMID: 35316762

    		 Sample: sera
  286. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021) IF: 3.575
    Effects of hydroxysafflor yellow A on rats with collagen-induced arthritis

    DOI: 10.1016/j.bbrc.2021.07.026

    PMID: 34271433

    		 Sample: serum
  287. METABOLIC BRAIN DISEASE (2021) IF: 3.584
    Dichloroacetic acid-induced dysfunction in rat hippocampus and the protective effect of curcumin

    DOI: 10.1007/s11011-020-00657-5

    PMID: 33411217

    		 Sample: hippocampal tissues
  288. NEUROSCIENCE (2018) IF: 3.59
    Inhibiting Succinate Dehydrogenase by Dimethyl Malonate Alleviates Brain Damage in a Rat Model of Cardiac Arrest

    DOI: 10.1016/j.neuroscience.2018.09.041

    PMID: 30300703

    		 Sample: Serum
  289. NEUROSCIENCE (2021) IF: 3.59
    Hydrogen Alleviates Neuronal Injury and Neuroinflammation Induced by Microglial Activation via the Nuclear Factor Erythroid 2-related Factor 2 Pathway in Sepsis-associated Encephalopathy

    DOI: 10.1016/j.neuroscience.2021.05.003

    PMID: 33992722

    		 Sample: Cell culture supernatant,Tissue homogenate(Brain)
  290. BMC IMMUNOLOGY (2022) IF: 3.594
    NLRP3 inflammasome up-regulates major histocompatibility complex class I expression and promotes inflammatory infiltration in polymyositis

    DOI: 10.1186/s12865-022-00515-2

    PMID: 35965334

    		 Sample: serum,muscle
  291. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2020) IF: 3.606
    Neuroprotective role of gallic acid in aflatoxin B1‐induced behavioral abnormalities in rats

    DOI: 10.1002/jbt.22684
    Sample: cerebrum tissue lysate supernatant
  292. LIFE SCIENCES (2020) IF: 3.647
    Lauric acid ameliorates lipopolysaccharide (LPS)-induced liver inflammation by mediating TLR4/MyD88 pathway in Sprague Dawley (SD) rats

    DOI: 10.1016/j.lfs.2020.118750

    PMID: 33188836

    		 Sample: Serum
  293. LIFE SCIENCES (2020) IF: 3.647
    IFI16 contributes to the pathogenesis of abdominal aortic aneurysm by regulating the caspase-1/IL-1β/MCPIP1 pathway

    DOI: 10.1016/j.lfs.2020.118752

    PMID: 33188834

    		 Sample: Cell culture supernatant
  294. LIFE SCIENCES (2020) IF: 3.647
    Attenuation of chronic arsenic neurotoxicity via melatonin in male offspring of maternal rats exposed to arsenic during conception: Involvement of oxidative DNA damage and inflammatory signaling cascades

    DOI: 10.1016/j.lfs.2020.118876

    PMID: 33310035

    		 Sample: Tissue homogenate
  295. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2022) IF: 3.652
    The cardioprotective effects of perindopril in a model of polymicrobial sepsis: The role of radical oxygen species and the inflammation pathway

    DOI: 10.1002/jbt.23080
    Sample: heart tissue
  296. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021) IF: 3.652
    Biochemical and histological alterations of doxorubicin-induced neurotoxicity in rats: Protective role of luteolin

    DOI: 10.1002/jbt.22962

    PMID: 34766659

    		 Sample: brain
  297. JOURNAL OF ETHNOPHARMACOLOGY (2020) IF: 3.69
    Water extract of Armillaria mellea (Vahl) P. Kumm. Alleviates the depression-like behaviors in acute- and chronic mild stress-induced rodent models via anti-inflammatory action

    DOI: 10.1016/j.jep.2020.113395

    PMID: 32956757

    		 Sample: Serum,Tissue homogenate
  298. JOURNAL OF ETHNOPHARMACOLOGY (2020) IF: 3.69
    Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4/MyD88/NF-κB and TGF-β/smads signaling pathways

    DOI: 10.1016/j.jep.2020.113275

    PMID: 32810620

    		 Sample: Serum
  299. JOURNAL OF ETHNOPHARMACOLOGY (2020) IF: 3.69
    Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways

    DOI: 10.1016/j.jep.2020.113039

    PMID: 32497675

    		 Sample: Serum,Cell culture supernatant
  300. CELL CYCLE (2020) IF: 3.699
    Knockdown of circular RNA circMAT2B reduces oxygen-glucose deprivation-induced inflammatory injury in H9c2 cells through up-regulating miR-133

    DOI: 10.1080/15384101.2020.1814025

    PMID: 32897801

    		 Sample: Cell culture supernatant
  301. BRAIN RESEARCH BULLETIN (2023) IF: 3.715
    Acetaldehyde dehydrogenase 2 activation attenuates sepsis-induced brain injury through NLRP3 inflammasome regulation

    DOI: 10.1016/j.brainresbull.2023.01.012
    Sample: serum
  302. BIOLOGICAL TRACE ELEMENT RESEARCH (2022) IF: 3.738
    Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1–7 Signals

    DOI: 10.1007/s12011-022-03286-4
    Sample: kidney
  303. Bosnian Journal of Basic Medical Sciences (2022) IF: 3.759
    Tenofovir-silver nanoparticles conjugate ameliorates neurocognitive disorders and protects ultrastructural and cytoarchitectonic properties of the prefrontal cortex in diabetic rats

    DOI: 10.17305/bjbms.2021.6699
    Sample: prefrontal cortex (PFC)
  304. PHYTOTHERAPY RESEARCH (2019) IF: 3.766
    Vernonia amygdalina inhibited osteoarthritis development by anti‐inflammatory and anticollagenase pathways in cartilage explant and osteoarthritis‐induced rat model

    DOI: 10.1002/ptr.6366
    Sample: serum
  305. Heliyon (2020) IF: 3.776
    In vivo exposure to codeine induces reproductive toxicity: role of HER2 and p53/Bcl-2 signaling pathway

    DOI: 10.1016/j.heliyon.2020.e05589
    Sample: testicular
  306. Frontiers in Pharmacology (2018) IF: 3.831
    PSTPIP2 Inhibits the Inflammatory Response and Proliferation of Fibroblast-Like Synoviocytes in vitro

    DOI: 10.3389/fphar.2018.01432

    PMID: 30564127

    		 Sample: Serum,Cell culture supernatant
  307. Frontiers in Pharmacology (2018) IF: 3.831
    Anti-inflammatory Mechanism of Geniposide: Inhibiting the Hyperpermeability of Fibroblast-Like Synoviocytes via the RhoA/p38MAPK/NF-κB/F-Actin Signal Pathway

    DOI: 10.3389/fphar.2018.00105
    Sample: fibroblast-like synoviocytes (FLSs)
  308. BIOSCIENCE REPORTS (2019) IF: 3.84
    Up-regulated MCPIP1 in abdominal aortic aneurysm is associated with vascular smooth muscle cell apoptosis and MMPs production

    DOI: 10.1042/BSR20191252

    PMID: 31651935

    		 Sample: Serum,Plasma,Cell sample
  309. Frontiers in Pharmacology (2019) IF: 3.845
    Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer’s Disease-Like Complications of Diabetes

    DOI: 10.3389/fphar.2019.00288
    Sample: hippocampus tissues
  310. PEPTIDES (2023) IF: 3.867
    Irisin prevents hypoxic-ischemic brain damage in rats by inhibiting oxidative stress and protecting the blood-brain barrier

    DOI: 10.1016/j.peptides.2023.170945
    Sample: brain
  311. JOURNAL OF CELLULAR PHYSIOLOGY (2018) IF: 3.923
    8‐Br‐cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia–reperfusion injury

    DOI: 10.1002/jcp.27236
    Sample: Plasma
  312. Annals of Translational Medicine (2022) IF: 3.932
    The method of Yiqi Yangyin Tongluo can attenuate the pyroptosis of rheumatoid arthritis chondrocytes through the ASIC1a/NLRP3 signaling pathway

    DOI: 10.21037/atm-21-6822

    PMID: 35284559

    		 Sample: serum
  313. INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
    Klotho ameliorates the onset and progression of cataract via suppressing oxidative stress and inflammation in the lens in streptozotocin-induced diabetic rats

    DOI: 10.1016/j.intimp.2020.106582

    PMID: 32438076

    		 Sample: Plasma
  314. INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
    Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis

    DOI: 10.1016/j.intimp.2020.106771

    PMID: 32683302

    		 Sample: Serum
  315. INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
    Betulin alleviates on myocardial inflammation in diabetes mice via regulating Siti1/NLRP3/NF-κB pathway

    DOI: 10.1016/j.intimp.2020.106653
    Sample: H9c2 cell
  316. THROMBOSIS RESEARCH (2021) IF: 3.944
    Brain-derived extracellular vesicles mediated coagulopathy, inflammation and apoptosis after sepsis

    DOI: 10.1016/j.thromres.2021.09.014

    PMID: 34583153

    		 Sample: blood
  317. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021) IF: 3.981
    The beneficial activity of curcumin and resveratrol loaded in nanoemulgel for healing of burn-induced wounds

    DOI: 10.1016/j.jddst.2021.102360
    Sample: Tissue homogenate
  318. Scientific Reports (2020) IF: 3.998
    The effects of exercise treatment on learning and memory ability, and cognitive performance in diet-induced prediabetes animals

    DOI: 10.1038/s41598-020-72098-0

    PMID: 32929110

    		 Sample: Tissue homogenate
  319. Scientific Reports (2020) IF: 3.998
    Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats

    DOI: 10.1038/s41598-020-59411-7
    Sample: serum
  320. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2021) IF: 2.043
    miR-484 targeting of Yap1-induced LPS-inhibited proliferation, and promoted apoptosis and inflammation in cardiomyocyte

    DOI: 10.1093/bbb/zbaa009

    PMID: 33604630

    		 Sample: Cell culture supernatant(H9c2 cells)
  321. Evidence-based Complementary and Alternative Medicine (2018) IF: 2.064
    Sheng-Di-Da-Huang Decoction Inhibited Inflammation Expressed in Microglia after Intracerebral Hemorrhage in Rats

    DOI: 10.1155/2018/6470534
    Sample: brain tissues
  322. Brain and Behavior (2020) IF: 2.091
    Fetal exposure to dichloroacetic acid and impaired cognitive function in the adulthood

    DOI: 10.1002/brb3.1801
    Sample: hippocampal tissue
  323. Molecular Medicine Reports (2020) IF: 2.1
    Troxerutin attenuates oxygen‑glucose deprivation and reoxygenation‑induced oxidative stress and inflammation by enhancing the PI3K/AKT/HIF‑1α signaling pathway in H9C2 cardiomyocytes

    DOI: 10.3892/mmr.2020.11207
    Sample: Cell culture supernatant
  324. Molecular Medicine Reports (2020) IF: 2.1
    Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy

    DOI: 10.3892/mmr.2020.11312

    PMID: 32705206

    		 Sample: Serum
  325. INFLAMMATION RESEARCH (2014) IF: 2.143
    Effect of retinoic acid on the function of lipopolysaccharide-stimulated bone marrow stromal cells grown on titanium surfaces

    DOI: 10.1007/s00011-014-0784-7
    Sample: Cell culture supernatant
  326. NEUROSCIENCE LETTERS (2018) IF: 2.159
    Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats

    DOI: 10.1016/j.neulet.2018.06.023
    Sample: Tissue homogenate
  327. HUMAN & EXPERIMENTAL TOXICOLOGY (2019) IF: 2.171
    Hepatorenal protective effects of protocatechuic acid in rats administered with anticancer drug methotrexate:

    DOI: 10.1177/0960327119871095
    Sample: hepatic and renal
  328. Therapeutic Advances in Endocrinology and Metabolism (2020) IF: 2.173
    Plant-derived oleanolic acid ameliorates markers of subclinical inflammation and innate immunity activation in diet-induced pre-diabetic rats:

    DOI: 10.1177/2042018820935771
    Sample: Plasma
  329. Biomed Research International (2019) IF: 2.197
    Galangin Suppresses Renal Inflammation via the Inhibition of NF-κB, PI3K/AKT and NLRP3 in Uric Acid Treated NRK-52E Tubular Epithelial Cells

    DOI: 10.1155/2019/3018357

    PMID: 31240210

    		 Sample: Cell culture supernatant
  330. FEBS Open Bio (2020) IF: 2.231
    ASIC1a inhibits cell pyroptosis induced by acid‐induced activation of rat hepatic stellate cells

    DOI: 10.1002/2211-5463.12850

    PMID: 32237041

    		 Sample: Cell culture medium
  331. Toxicology Research (2020) IF: 2.283
    The effects of phenanthrene exposure on Treg and Th17 cells related cytokines in female rats

    DOI: 10.1093/toxres/tfaa030

    PMID: 32670559

    		 Sample: Tissue homogenate
  332. SOUTH AFRICAN JOURNAL OF BOTANY (2021) IF: 2.315
    Investigation of therapeutic potential of three endemic Cirsium species for global health problem obesity

    DOI: 10.1016/j.sajb.2021.05.004
    Sample: Serum
  333. CLINICAL RHEUMATOLOGY (2020) IF: 2.394
    Investigation of the efficacy of daidzein in experimental knee osteoarthritis-induced with monosodium iodoacetate in rats

    DOI: 10.1007/s10067-020-04958-z

    PMID: 32103372

    		 Sample: Serum
  334. Canadian Respiratory Journal (2022) IF: 2.409
    Chitosan-Coated Solid Lipid Nano-Encapsulation Improves the Therapeutic Antiairway Inflammation Effect of Berberine against COPD in Cigarette Smoke-Exposed Rats

    DOI: 10.1155/2022/8509396

    PMID: 35465190

    		 Sample: BALF
  335. METABOLIC BRAIN DISEASE (2019) IF: 2.411
    attenuates hydrogen peroxide induced oxidative toxicity in PC12 cells

    DOI: 10.1007/s11011-019-00440-1
    Sample: PC12 cells
  336. EXPERIMENTAL PHYSIOLOGY (2020) IF: 2.431
    Combination of quercetin and exercise training attenuates depression in rats with 1,2‐dimethylhydrazine‐induced colorectal cancer: Possible involvement of inflammation and BDNF signalling

    DOI: 10.1113/EP088605
    Sample: Serum,Tissue homogenate
  337. Experimental and Therapeutic Medicine (2021) IF: 2.447
    Graphene oxide induces dose‑dependent lung injury in rats by regulating autophagy

    DOI: 10.3892/etm.2021.9893
    Sample: Tissue homogenate
  338. Experimental and Therapeutic Medicine (2021) IF: 2.447
    Gadolinium chloride pre‑treatment reduces the inflammatory response and preserves intestinal barrier function in a rat model of sepsis

    DOI: 10.3892/etm.2021.10577
    Sample: serum,intestinal tissue
  339. Experimental and Therapeutic Medicine (2021) IF: 2.447
    Emodin ameliorates acute pancreatitis‑induced lung injury by suppressing NLRP3 inflammasome‑mediated neutrophil recruitment

    DOI: 10.3892/etm.2021.10289
    Sample: serum
  340. Experimental and Therapeutic Medicine (2021) IF: 2.447
    Activated protein C overexpression suppresses the pyroptosis of subarachnoid hemorrhage model cells by regulating the NLRP3 inflammasome pathway

    DOI: 10.3892/etm.2021.10827

    PMID: 34650639

    		 Sample: brain tissue
  341. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2022) IF: 2.457
    Maternal prenatal stress and depression-like behavior associated with hippocampal and cortical neuroinflammation in the offspring: An experimental study

    DOI: 10.1002/jdn.10176

    PMID: 35261075

    		 Sample: hippocampus
  342. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017) IF: 2.466
    Umbilical cord-derived mesenchymal stem cells alleviated inflammation and inhibited apoptosis in interstitial cystitis via AKT/mTOR signaling pathway

    DOI: 10.1016/j.bbrc.2017.11.072
    Sample: Tissue homogenate
  343. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2022) IF: 2.471
    Healing Potential of Propolis Extract–Passiflora edulis Seed Oil Emulgel Against Excisional Wound: Biochemical, Histopathological, and Cytokines Level Evidence

    DOI: 10.1089/adt.2022.075
    Sample: Skin samples
  344. Cardiovascular Engineering and Technology (2021) IF: 2.495
    The Mitochondrial-Derived Peptide MOTS-c Attenuates Oxidative Stress Injury and the Inflammatory Response of H9c2 Cells Through the Nrf2/ARE and NF-κB Pathways

    DOI: 10.1007/s13239-021-00589-w

    PMID: 34859377

    		 Sample: H9c2 cell
  345. NEUROLOGICAL RESEARCH (2022) IF: 2.529
    Investigation of therapeutic effects of calcium dobesilate in cerebral hypoxia/ reperfusion injury in rats

    DOI: 10.1080/01616412.2022.2159109
    Sample: brains
  346. Iranian Journal of Basic Medical Sciences (2022) IF: 2.532
    Cobalt exposure triggers impairments in cognitive and anxiety-like behaviors, brain oxidative stress and inflammation, and hippocampo-amygdala histomorphological alterations: Protective role of aqueous Prosopis africana seed extract

    DOI: 10.22038/IJBMS.2022.65689.14456
    Sample: Brain
  347. BIOSCIENCE REPORTS (2019) IF: 2.535
    Thousand and one kinase 1 protects MCAO-induced cerebral ischemic stroke in rats by decreasing apoptosis and pro-inflammatory factors

    DOI: 10.1042/BSR20190749
    Sample: brain,neural stem cells
  348. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018) IF: 2.559
    Serum thyroid hormones levels are significantly decreased in pregnant rats with acute pancreatitis

    DOI: 10.1016/j.bbrc.2018.09.180

    PMID: 30286956

    		 Sample: Serum
  349. CELL BIOLOGY INTERNATIONAL (2020) IF: 2.571
    Acid‐sensing ion channel 1a mediates acid‐induced pyroptosis through calpain‐2/calcineurin pathway in rat articular chondrocytes

    DOI: 10.1002/cbin.11422
    Sample: Cell culture supernatant
  350. TISSUE & CELL (2022) IF: 2.586
    Resveratrol alleviates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition and down-regulating TLR4/NF-κB and TGF-β1/smad3 signalling pathways in rats

    DOI: 10.1016/j.tice.2022.101953

    PMID: 36228366

    		 Sample: Lung tissue
  351. BMC Pharmacology & Toxicology (2022) IF: 2.605
    Accidental lead in contaminated pipe-borne water and dietary furan intake perturbs rats’ hepatorenal function altering oxidative, inflammatory, and apoptotic balance

    DOI: 10.1186/s40360-022-00615-0
    Sample: hepatic,renal
  352. RENAL FAILURE (2019) IF: 2.606
    Diabetes aggravates renal ischemia and reperfusion injury in rats by exacerbating oxidative stress, inflammation, and apoptosis

    DOI: 10.1080/0886022X.2019.1643737
    Sample: renal
  353. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2020) IF: 2.614
    Tiliacora triandra extract and its major constituent attenuates diabetic kidney and testicular impairment by modulating redox imbalance and pro‐inflammatory responses in rats

    DOI: 10.1002/jsfa.10779
    Sample: Tissue homogenate
  354. Evidence-based Complementary and Alternative Medicine (2021) IF: 2.63
    Si-Miao-Yong-An Decoction Maintains the Cardiac Function and Protects Cardiomyocytes from Myocardial Ischemia and Reperfusion Injury

    DOI: 10.1155/2021/8968464
    Sample: H9C2 cells
  355. Evidence-based Complementary and Alternative Medicine (2021) IF: 2.63
    Moxibustion against Cyclophosphamide-Induced Premature Ovarian Failure in Rats through Inhibiting NLRP3-/Caspase-1-/GSDMD-Dependent Pyroptosis

    DOI: 10.1155/2021/8874757

    PMID: 33613687

    		 Sample: Serum
  356. ENVIRONMENTAL TOXICOLOGY (2019) IF: 2.649
    Cadmium and nickel co‐exposure exacerbates genotoxicity and not oxido‐inflammatory stress in liver and kidney of rats: Protective role of omega‐3 fatty acid

    DOI: 10.1002/tox.22860
    Sample: Tissue homogenate
  357. BIOMARKERS (2022) IF: 2.663
    Justicia carnea extracts ameliorated hepatocellular damage in streptozotocin-induced type 1 diabetic male rats via decrease in oxidative stress, inflammation and increasing other risk markers

    DOI: 10.1080/1354750X.2022.2157487
    Sample: liver
  358. INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2022) IF: 2.687
    Evaluation of the therapeutic effects of calcium dobesilate in sciatic nerve crush injury in rats

    DOI: 10.1016/j.injury.2022.08.061

    PMID: 36070970

    		 Sample: sciatic nerve
  359. EXPERIMENTAL BIOLOGY AND MEDICINE (2020) IF: 2.691
    Protective effect of exogenous hydrogen sulfide on diaphragm muscle fibrosis in streptozotocin-induced diabetic rats:

    DOI: 10.1177/1535370220931038
    Sample: Tissue homogenate
  360. Journal of Experimental Zoology Part A-Ecological and Integrative Physiology (2022) IF: 2.693
    Molecular mechanisms underlying ameliorative impact of melatonin against age-dependent chronic arsenic toxicity in rats' brains

    DOI: 10.1002/jez.2603
    Sample: brain
  361. Brain and Behavior (2021) IF: 2.708
    Melatonin salvages lead-induced neuro-cognitive shutdown, anxiety, and depressive-like symptoms via oxido-inflammatory and cholinergic mechanisms

    DOI: 10.1002/brb3.2227

    PMID: 34087957

    		 Sample: brain
  362. JOURNAL OF FOOD BIOCHEMISTRY (2022) IF: 2.72
    Effect of coconut water and milk on heat stress-induced gastrointestinal tract dysmotility in rats: Role of oxidative stress and inflammatory response

    DOI: 10.1111/jfbc.14129

    PMID: 35298033

    		 Sample: stomach
  363. JOURNAL OF FOOD BIOCHEMISTRY (2021) IF: 2.72
    Chlorogenic acid co-administration abates tamoxifen-mediated reproductive toxicities in male rats: An experimental approach

    DOI: 10.1111/jfbc.13615

    PMID: 33491243

    		 Sample: Tissue homogenate
  364. EUROPEAN JOURNAL OF PHARMACOLOGY (2016) IF: 2.73
    The protective role of neuregulin-1: A potential therapy for sepsis-induced cardiomyopathy

    DOI: 10.1016/j.ejphar.2016.06.042
    Sample: Serum
  365. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY (2017) IF: 2.733
    Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model

    DOI: 10.1097/GME.0000000000000882
    Sample: serum
  366. DARU-Journal of Pharmaceutical Sciences (2020) IF: 2.739
    Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model

    DOI: 10.1007/s40199-020-00343-y

    PMID: 32388789

    		 Sample: Serum
  367. PLoS One (2020) IF: 2.74
    Associations of inflammatory markers with impaired left ventricular diastolic and systolic function in collagen-induced arthritis

    DOI: 10.1371/journal.pone.0230657

    PMID: 32208438

    		 Sample: Serum
  368. Experimental and Therapeutic Medicine (2022) IF: 2.751
    S100A9‑containing serum exosomes obtained from patients with burn injuries promote myocardial cell pyroptosis through NLRP3

    DOI: 10.3892/etm.2022.11583

    PMID: 36277145

    		 Sample: AC16 cell
  369. Experimental and Therapeutic Medicine (2022) IF: 2.751
    1,2,3,4,6‑penta‑O‑galloyl‑β‑D‑glucose alleviates inflammation and oxidative stress in diabetic nephropathy rats through MAPK/NF‑κB and ERK/Nrf2/HO‑1 signaling pathways

    DOI: 10.3892/etm.2022.11576

    PMID: 36160883

    		 Sample: MPC5 cell
  370. Pharmacological Reports (2020) IF: 2.754
    Pro-inflammatory cytokines, but not brain- and extracellular matrix-derived proteins, are increased in the plasma following electrically induced kindling of seizures

    DOI: 10.1007/s43440-020-00208-w

    PMID: 33377994

    		 Sample: Plasma
  371. Pharmacological Reports (2020) IF: 2.754
    Agomelatine prevents indomethacin-induced gastric ulcer in rats

    DOI: 10.1007/s43440-019-00049-2
    Sample: gastric tissue
  372. ANDROLOGIA (2021) IF: 2.775
    Achillea millefolium alleviates testicular damage in paclitaxel-intoxicated rats via attenuation of testicular oxido-inflammatory stress and apoptotic responses

    DOI: 10.1111/and.14028

    PMID: 33650701

    		 Sample: Tissue homogenate(testicular)
  373. Radiation Oncology (2020) IF: 2.817
    Hippocampal changes in inflammasomes, apoptosis, and MEMRI after radiation-induced brain injury in juvenile rats

    DOI: 10.1186/s13014-020-01525-3

    PMID: 32276638

    		 Sample: Tissue homogenate
  374. JOURNAL OF NEUROIMMUNOLOGY (2019) IF: 2.832
    The role of UCH-L1, MMP-9, and GFAP as peripheral markers of different susceptibility to seizure development in a preclinical model of epilepsy

    DOI: 10.1016/j.jneuroim.2019.03.018

    PMID: 30952062

    		 Sample: Plasma
  375. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy (2020) IF: 2.842
    Kukoamine B Ameliorate Insulin Resistance, Oxidative Stress, Inflammation and Other Metabolic Abnormalities in High-Fat/High-Fructose-Fed Rats

    DOI: 10.2147/DMSO.S247844
    Sample: serum
  376. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy (2020) IF: 2.842
    Activation of Nrf2 Signaling by Apelin Attenuates Renal Ischemia Reperfusion Injury in Diabetic Rats

    DOI: 10.2147/DMSO.S246743

    PMID: 32606875

    		 Sample: Serum
  377. WOUND REPAIR AND REGENERATION (2019) IF: 2.85
    Effects of depression on healing and inflammatory responses of acute wounds in rats

    DOI: 10.1111/wrr.12726
    Sample: serum
  378. Toxin Reviews (2020) IF: 2.851
    Nicotine lowers TNF-α, IL-1b secretion and leukocyte accumulation via nAChR in rat stomach

    DOI: 10.1080/15569543.2020.1790604
    Sample: Tissue homogenate
  379. 3 Biotech (2022) IF: 2.893
    Nephroprotective effect of polyphenol-rich extract of Costus spicatus in cisplatin-induced nephrotoxicity in Wistar albino rats

    DOI: 10.1007/s13205-022-03233-z

    PMID: 35903285

    		 Sample: Kidney tissue
  380. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2019) IF: 2.895
    Rutin abrogates manganese—Induced striatal and hippocampal toxicity via inhibition of iron depletion, oxidative stress, inflammation and suppressing the NF-κB signaling pathway

    DOI: 10.1016/j.jtemb.2019.01.014
    Sample: Tissue homogenate
  381. BIOSCIENCE REPORTS (2018) IF: 2.899
    Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats

    DOI: 10.1042/BSR20180892

    PMID: 30232232

    		 Sample: Tissue homogenate
  382. HUMAN & EXPERIMENTAL TOXICOLOGY (2021) IF: 2.903
    Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis:

    DOI: 10.1177/09603271211006171
    Sample: Tissue homogenate
  383. HUMAN & EXPERIMENTAL TOXICOLOGY (2021) IF: 2.903
    Carvacrol hinders the progression of hepatic fibrosis via targeting autotaxin and thioredoxin in thioacetamide-induced liver fibrosis in rat:

    DOI: 10.1177/09603271211026729
    Sample: liver
  384. HUMAN & EXPERIMENTAL TOXICOLOGY (2021) IF: 2.903
    Biochemical assessment of the neurotoxicity of gold nanoparticles functionalized with colorectal cancer-targeting peptides in a rat model:

    DOI: 10.1177/09603271211017611
    Sample: Tissue homogenate(brain)
  385. Future Microbiology (2020) IF: 2.907
    The anti-inflammatory, anti-oxidant and protective effects of a probiotic mixture on organ toxicity in a rat model

    DOI: 10.2217/fmb-2020-0005

    PMID: 32250184

    		 Sample: Serum
  386. INFLAMMATION (2019) IF: 2.939
    Nobiletin Protects from Renal Ischemia-Reperfusion Injury in Rats by Suppressing Inflammatory Cytokines and Regulating iNOS-eNOS Expressions

    DOI: 10.1007/s10753-019-01123-w

    PMID: 31705353

    		 Sample: Serum
  387. Molecular Medicine Reports (2021) IF: 2.952
    NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease

    DOI: 10.3892/mmr.2021.12035

    PMID: 33864663

    		 Sample: Cell
  388. Molecular Medicine Reports (2018) IF: 2.952
    C5a aggravates dysfunction of the articular cartilage and synovial fluid in rats with knee joint immobilization

    DOI: 10.3892/mmr.2018.9208
    Sample: Synovial fluid,Tissue homogenate
  389. JOURNAL OF CELLULAR BIOCHEMISTRY (2018) IF: 2.959
    Exosomes derived from miR‐146a‐modified adipose‐derived stem cells attenuate acute myocardial infarction−induced myocardial damage via downregulation of early growth response factor 1

    DOI: 10.1002/jcb.27731
    Sample: Serum,Cell culture supernatant
  390. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2019) IF: 2.965
    Protective effect of betulinic acid on Freund's complete adjuvant‐induced arthritis in rats

    DOI: 10.1002/jbt.22373
    Sample: serum,synovium
  391. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2019) IF: 2.965
    Fluoride and diethylnitrosamine coexposure enhances oxido‐inflammatory responses and caspase‐3 activation in liver and kidney of adult rats

    DOI: 10.1002/jbt.22327
    Sample: Serum
  392. PHARMACEUTICAL BIOLOGY (2020) IF: 2.971
    Effect of phenylacetamide isolated from lepidium apetalum on myocardial injury in spontaneously hypertensive rats and its possible mechanism

    DOI: 10.1080/13880209.2020.1778043
    Sample: myocardial tissue
  393. JOURNAL OF ETHNOPHARMACOLOGY (2017) IF: 2.981
    Renoprotective and antioxidative effects of methanolic Paederia foetida leaf extract on experimental diabetic nephropathy in rats

    DOI: 10.1016/j.jep.2017.01.035
    Sample: Serum,Tissue homogenate
  394. PeerJ (2021) IF: 2.984
    Melatonin ameliorates myocardial injury by reducing apoptosis and autophagy of cardiomyocytes in a rat cardiopulmonary bypass model

    DOI: 10.7717/peerj.11264

    PMID: 33954056

    		 Sample: Plasma
  395. JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2017) IF: 1.099
    Fetal liver injury ameliorated by migration inhibitory factor inhibition in a rat model of acute pancreatitis in pregnancy

    DOI: 10.1111/jog.13538
    Sample: serum
  396. Annals of Surgical Treatment and Research (2019) IF: 1.181
    Examination of protective and therapeutic effects of ruscogenin on cerulein-induced experimental acute pancreatitis in rats

    DOI: 10.4174/astr.2019.97.6.271

    PMID: 31824881

    		 Sample: Serum,Tissue homogenate
  397. CHEMICAL & PHARMACEUTICAL BULLETIN (2018) IF: 1.258
    Anti-inflammatory Effects of a Small Molecule Gastrin-Releasing Peptide Receptor Antagonist on Adjuvant-Induced Rheumatoid Arthritis in rats

    DOI: 10.1248/cpb.c17-00887
    Sample: serum
  398. Experimental and Therapeutic Medicine (2017) IF: 1.261
    Tocotrienol alleviates inflammation and oxidative stress in a rat model of spinal cord injury via suppression of transforming growth factor-β

    DOI: 10.3892/etm.2017.4505
    Sample: Serum
  399. Brazilian Journal of Cardiovascular Surgery (2021) IF: 1.312
    Probiotic Saccharomyces boulardii Alleviates Lung Injury by Reduction of Oxidative Stress and Cytokine Response Induced by Supraceliac Aortic Ischemia-Reperfusion Injury in Rats

    DOI: 10.21470/1678-9741-2020-0153
    Sample: serum,Lung tissue
  400. CONTRIBUTIONS TO PLASMA PHYSICS (2018) IF: 1.318
    Effects and mechanisms of cold atmospheric plasma on skin wound healing of rats

    DOI: 10.1002/ctpp.201800025
    Sample: skin tissues
  401. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2019) IF: 1.351
    Electroacupuncture reduces astrocyte number and oxidative stress in aged rats with surgery-induced cognitive dysfunction:

    DOI: 10.1177/0300060519860026
    Sample: Serum
  402. JOURNAL OF FOOD BIOCHEMISTRY (2019) IF: 1.358
    Epicatechin and scopoletin rich Morinda citrifolia (Noni) leaf extract supplementation, mitigated Osteoarthritis via anti‐inflammatory, anti‐oxidative, and anti‐protease pathways

    DOI: 10.1111/jfbc.12755
    Sample: Serum
  403. Experimental and Therapeutic Medicine (2018) IF: 1.41
    Protective effect of dexpanthenol against cisplatin‑induced hepatotoxicity

    DOI: 10.3892/etm.2018.6683
    Sample: Tissue homogenate
  404. ARQUIVOS DE NEURO-PSIQUIATRIA (2022) IF: 1.42
    Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats

    DOI: 10.1590/0004-282X-ANP-2021-0101

    PMID: 35239805

    		 Sample: brain tissue,serum
  405. PATHOLOGY RESEARCH AND PRACTICE (2018) IF: 1.466
    miR-93-3p alleviates lipopolysaccharide-induced inflammation and apoptosis in H9c2 cardiomyocytes by inhibiting toll-like receptor 4

    DOI: 10.1016/j.prp.2018.08.024

    PMID: 30195636

    		 Sample: Cell culture supernatant
  406. Natural Product Communications (2023) IF: 1.496
    Vanillic Acid Alleviates Right Ventricular Function in Rats With MCT-Induced Pulmonary Arterial Hypertension

    DOI: 10.1177/1934578X221148896
    Sample: serum
  407. PEDIATRICS INTERNATIONAL (2021) IF: 1.524
    Early administration of milrinone ameliorates lung and kidney injury during sepsis in juvenile rats

    DOI: 10.1111/ped.14917

    PMID: 34242458

    		 Sample: Lung，kidney
  408. ORL-Journal for Oto-Rhino-Laryngology Head and Neck Surgery (2022) IF: 1.538
    Mucolytic and Antioxidant Effects of Intranasal Acetylcysteine Use on Acute Rhinosinusitis in Rats with an Acute Rhinosinusitis Model

    DOI: 10.1159/000524869

    PMID: 35661091

    		 Sample: nose,sinuses
  409. PATHOLOGY RESEARCH AND PRACTICE (2017) IF: 1.543
    A preliminary study on fetal lung injury in a rat model of acute pancreatitis in pregnancy

    DOI: 10.1016/j.prp.2017.09.016
    Sample: serum
  410. Molecular Medicine Reports (2015) IF: 1.554
    Asiaticoside attenuates the effects of spinal cord injury through antioxidant and anti‑inflammatory effects, and inhibition of the p38‑MAPK mechanism

    DOI: 10.3892/mmr.2015.4425
    Sample: Serum
  411. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2023) IF: 1.573
    Effect of zinc supplementation on immunotoxicity induced by subchronic oral exposure to glyphosate-based herbicide (GOBARA®) in Wistar rats

    DOI: 10.1177/03000605221147188
    Sample: Serum
  412. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2016) IF: 1.617
    Anti-oxidant and anti-inflammatory effects of apigenin in a rat model of sepsis: an immunological, biochemical, and histopathological study

    DOI: 10.3109/08923973.2016.1173058
    Sample: Serum
  413. Journal of Oleo Science (2022) IF: 1.628
    Chemoprotective Effect of Decalactone on Hepatic Cancer via Diminishing the Inflammatory Response and Oxidative Stress

    DOI: 10.5650/jos.ess22033

    PMID: 35965085

    		 Sample: liver
  414. JOURNAL OF FOOD BIOCHEMISTRY (2020) IF: 1.662
    The effects of chrysin on lipopolysaccharide‐induced sepsis in rats

    DOI: 10.1111/jfbc.13359
    Sample: lung,liver,kidney
  415. RENAL FAILURE (2019) IF: 1.687
    The aqueous extract of aged black garlic ameliorates colistin-induced acute kidney injury in rats

    DOI: 10.1080/0886022X.2018.1561375

    PMID: 30714460

    		 Sample: Tissue homogenate
  416. Molecular Medicine Reports (2017) IF: 1.692
    Neuroprotective effects of curcumin alleviate lumbar intervertebral disc degeneration through regulating the expression of iNOS, COX‑2, TGF‑β1/2, MMP‑9 and BDNF in a rat model

    DOI: 10.3892/mmr.2017.7464
    Sample: intervertebral discs
  417. BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT (2022) IF: 1.762
    Nelumbo nucifera Gaertn. leaves: network pharmacology and molecular docking analysis of active ingredients and their mechanisms of action in treating atherosclerosis

    DOI: 10.1080/13102818.2022.2116996
    Sample: serum
  418. Cutaneous and Ocular Toxicology (2021) IF: 1.82
    Effects of Achillea millefolium on cisplatin induced ocular toxicity: an experimental study

    DOI: 10.1080/15569527.2021.1919137

    PMID: 34180746

    		 Sample: ocular
  419. INTERNATIONAL UROLOGY AND NEPHROLOGY (2020) IF: 1.843
    Vinpocetine reduces cisplatin-induced acute kidney injury through inhibition of NF–κB pathway and activation of Nrf2/ARE pathway in rats

    DOI: 10.1007/s11255-020-02485-z
    Sample: Serum,Urine,Tissue homogenate
  420. Molecular Medicine Reports (2019) IF: 1.851
    MicroRNA‑22 alleviates inflammation in ischemic stroke via p38 MAPK pathways

    DOI: 10.3892/mmr.2019.10269
    Sample: serum
  421. Annals of Surgical Treatment and Research (2022) IF: 1.859
    Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats

    DOI: 10.4174/astr.2022.102.1.29

    PMID: 35071117

    		 Sample: colonic tissue
  422. Journal of Zhejiang University-SCIENCE B (2019) IF: 1.879
    Improvement in post-partum uterine involution in rats treated with Apios americana

    DOI: 10.1631/jzus.B1800475
    Sample: serum
  423. PHARMACEUTICAL BIOLOGY (2018) IF: 1.918
    Mechanism of TangGanJian on nonalcoholic fatty liver disease with type 2 diabetes mellitus

    DOI: 10.1080/13880209.2018.1504972
    Sample: serum
  424. MEDICAL SCIENCE MONITOR (2020) IF: 1.918
    Carbon Monoxide Inhibits the Expression of Proteins Associated with Intestinal Mucosal Pyroptosis in a Rat Model of Sepsis Induced by Cecal Ligation and Puncture

    DOI: 10.12659/MSM.920668
    Sample: serum,intestinal tissue
  425. Molecular Medicine Reports (2018) IF: 1.922
    Neuroprotective effect of tanshinone IIA weakens spastic cerebral palsy through inflammation, p38MAPK and VEGF in neonatal rats

    DOI: 10.3892/mmr.2017.8069
    Sample: hippocampus
  426. Toxicology Research (2017) IF: 1.969
    Nano NiO induced liver toxicity via activating the NF-κB signaling pathway in rats

    DOI: 10.1039/C6TX00444J
    Sample: Tissue homogenate
  427. MEDICAL SCIENCE MONITOR (2019) IF: 1.98
    Electroacupuncture Alleviates Ischemic Brain Injury by Inhibiting the miR-223/NLRP3 Pathway

    DOI: 10.12659/MSM.917213
    Sample: cortical
  428. Toxicology Reports (2019)
    Manganese suppresses oxidative stress, inflammation and caspase-3 activation in rats exposed to chlorpyrifos

    DOI: 10.1016/j.toxrep.2019.02.007

    PMID: 30859069

    		 Sample: Tissue homogenate
  429. Turkish Journal of Pharmaceutical Sciences (2021)
    Investigation of the Genotoxic, Cytotoxic, Apoptotic, and Oxidant Effects of Olive Leaf Extracts on Liver Cancer Cell Lines

    DOI: 10.4274/tjps.galenos.2021.03271
    Sample: H4IIE cell,clone-9 cell
  430. IBRO Neuroscience Reports (2022)
    Highly active antiretroviral therapy-silver nanoparticle conjugate interacts with neuronal and glial cells and alleviates anxiety-like behaviour in streptozotocin-induced diabetic rats

    DOI: 10.1016/j.ibneur.2022.06.003

    PMID: 35769902

    		 Sample: brain
  431. Brazilian Journal of Anesthesiology (2021)
    Dose-related effects of dexmedetomidine on sepsis-initiated lung injury in rats

    DOI: 10.1016/j.bjane.2021.02.051
    Sample: plasma
  432. Acta Cirurgica Brasileira (2017) IF: 0.729
    Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the P38-MAPK/TXNIP signaling activation in streptozotocin induced diabetic rats

    DOI: 10.1590/s0102-865020170060000003
    Sample: Serum,Plasma
  433. GENETICS AND MOLECULAR RESEARCH (2015) IF: 0.775
    Protective effect of penehyclidine hydrochloride on lipopolysaccharide-induced acute kidney injury in rat.

    DOI: 10.4238/2015.August.10.14
    Sample: serum
  434. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY (2018) IF: 0.796
    Dopamine Pretreatment Protects Offspring Rats from LPS-Induced Hypertension and Kidney Damage by Inhibiting NLRP3 Activation in Kidney

    DOI: 10.1134/S1068162018010077
    Sample: serum
  435. RENAL FAILURE (2016) IF: 0.875
    Effect of apelin hormone on renal ischemia/reperfusion induced oxidative damage in rats

    DOI: 10.1080/0886022X.2016.1184957
    Sample: Serum
  436. INDIAN JOURNAL OF PHARMACOLOGY (2020) IF: 0.888
    Mangiferin ameliorates intracerebroventricular-quinolinic acid-induced cognitive deficits, oxidative stress, and neuroinflammation in Wistar rats

    DOI: 10.4103/ijp.IJP_699_19
    Sample: Tissue homogenate
  437. Ulusal Travma ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery (2022) IF: 0.894
    Intraductal botulinum toxin injection suppressed the inflammation in experimental acute pancreatitis.

    DOI: 10.14744/tjtes.2021.90140
    Sample: Serum
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