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Rat IL-1β(Interleukin 1 Beta) ELISA Kit

  • Cat.No.:E-EL-R0012

  • Reactivity: Rat

To Purchase E-EL-R0012

  • 96T
  • 48T
  • 24T
  • 96T*5
  • 96T*10
Price: $495

Product Details


Assay type Sandwich-ELISA
Format 96T/48T
Assay time 3.5h
Detection range 31.25-2000 pg/mL
Sensitivity 18.75 pg/mL
Sample type &Sample volume serum, plasma and other biological fluids; 100μL
Specificity This kit recognizes Rat IL-1β in samples. No significant cross-reactivity or interference between Rat IL-1β and analogues was observed.
Reproducibility Both intra-CV and inter-CV are < 10%.
Application This ELISA kit applies to the in vitro quantitative determination of Rat IL-1β concentrations in serum, plasma and other biological fluids.

Test Principle

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat IL-1β. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Rat IL-1β and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Rat IL-1β, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of Rat IL-1β. You can calculate the concentration of Rat IL-1β in the samples by comparing the OD of the samples to the standard curve.

Kit components & Storage

An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the components separately according to the following conditions once the kit is received.
Micro ELISA Plate(Dismountable) 96T: 8 wells ×12 strips
48T: 8 wells ×6 strips
-20℃, 6 months
Reference Standard 96T: 2 vials
48T: 1 vial
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
-20℃(Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL
HRP Conjugate Diluent 1 vial, 14 mL
Concentrated Wash Buffer (25×) 1 vial, 30 mL
Substrate Reagent 1 vial, 10 mL 2-8℃(Protect from light)
Stop Solution 1 vial, 10 mL 2-8°C
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Technical Data


Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Rat IL-1β were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Rat IL-1β were tested on 3 different plates, 20 replicates in each plate.

  Intra-assay Precision Inter-assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (pg/mL) 100.50 314.20 880.10 107.40 340.60 954.80
Standard deviation 5.70 13.50 30.80 5.60 20.40 33.40
CV (%) 5.67 4.30 3.50 5.21 5.99 3.50


The recovery of Rat IL-1β spiked at three different levels in samples throughout the range of the assay was evaluated in various matrices.

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 85-98 91
EDTA plasma (n=8) 86-100 93
Cell culture media (n=8) 86-101 92


Samples were spiked with high concentrations of Rat IL-1β and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

Target Information

Database LinksSwissProt:   Q63264
SynonymsIL1B, IL1-BETA, IL1F2, catabolin
Research AreaCancer, Cardiovascular, Metabolism, Immunology

Assay Procedures

elisa assay procedure 1

1. Add 100μL standard or sample to the wells. Incubate for 90 min at 37°C

elisa assay procedure 2

2. Discard the liquid, immediately add 100μL Biotinylated Detection Ab working solution to each well. Incubate for 60 min at 37°C

elisa assay procedure 3

3. Aspirate and wash the plate for 3 times

elisa assay procedure 4

4. Add 100μL HRP conjugate working solution. Incubate for 30 min at 37°C. Aspirate and wash the plate for 5 times

elisa assay procedure 5

5. Add 90μL Substrate Reagent. Incubate for 15 min at 37°C

elisa assay procedure 6

6. Add 50μL Stop Solution

elisa assay procedure 7

7. Read the plate at 450nm immediately. Calculation of the results


From now on, if you have published a paper by using any of our products since 1/1/2019, fill out the “Elabscience Publication Reward Application Form”carefully and send it to, we will get back to you with the reward after we confirm it ASAP!

View more details about our Publication Reward >>

  1. ACS Applied Materials & Interfaces (2021) IF: 9.2289
    Self-Assembled pH-Sensitive Polymeric Nanoparticles for the Inflammation-Targeted Delivery of Cu/Zn-Superoxide Dismutase

    DOI: 10.1021/acsami.1c03589

    PMID: 33764751

    Sample: Plasma
  2. Environmental Pollution (2019) IF: 6.792
    Selenium abates reproductive dysfunction via attenuation of biometal accumulation, oxido-inflammatory stress and caspase-3 activation in male rats exposed to arsenic

    DOI: 10.1016/j.envpol.2019.113079

    PMID: 31473390

    Sample: Serum
  3. British journal of pharmacology (2018) IF: 6.81
    High-fructose corn syrup consumption in adolescent rats causes bipolar-like behavioural phenotype with hyperexcitability in hippocampal CA3-CA1 synapses

    DOI: 10.1111/bph.14500

    PMID: 30221753

    Sample: Serum
  4. Food & Function (2022) IF: 5.3
    Asiatic acid from Cyclocarya paliurus regulates the autophagy–lysosome system via directly inhibiting TGF-β type I receptor and ameliorates diabetic nephropathy fibrosis

    DOI: 10.1039/D1FO02445K

    PMID: 35531774

    Sample: Tissue homogenate
  5. Oxidative medicine and cellular longevity (2020) IF: 5.076
    Neuregulin-1 β Protects the Rat Diaphragm during Sepsis against Oxidative Stress and Inflammation by Activating the PI3K/Akt Pathway

    DOI: 10.1155/2020/1720961

    PMID: 32765805

    Sample: Serum,Tissue homogenate
  6. Journal of Cellular Physiology (2020) IF: 5.546
    Autophagy decreases alveolar epithelial cell injury by regulating the release of inflammatory mediators

    DOI: 10.1002/jcp.29453

    PMID: 31960959

    Sample: Cell culture supernatant,Tissue homogenate
  7. Materials Science and Engineering: C (2020) IF: 5.88
    The sustained release of dexamethasone from TiO2 nanotubes reinforced by chitosan to enhance osteoblast function and anti-inflammation activity

    DOI: 10.1016/j.msec.2020.111241

    Sample: Cell culture supernatant
  8. Translational Stroke Research (2020) IF: 5.78
    AAV/BBB-Mediated Gene Transfer of CHIP Attenuates Brain Injury Following Experimental Intracerebral Hemorrhage

    DOI: 10.1007/s12975-019-00715-w

    PMID: 31325153

    Sample: Plasma
  9. Antioxidants (2020) IF: 5.014
    Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol

    DOI: 10.3390/antiox9010085

    PMID: 31963913

    Sample: Plasma
  10. Chemosphere (2019) IF: 5.778
    Impact of binary waterborne mixtures of nickel and zinc on hypothalamic-pituitary-testicular axis in rats

    DOI: 10.1016/j.chemosphere.2019.124501

    PMID: 31398612

    Sample: Serum
  11. Aging (Albany NY) (2018) IF: 5.515
    Methanolic extract of Tamarix Gallica attenuates hyperhomocysteinemia induced AD-like pathology and cognitive impairments in rats

    DOI: 10.18632/aging.101627

    PMID: 30425189

    Sample: Tissue homogenate
  12. IF: 5.57
    Delivery of siRNA using folate receptor-targeted pH-sensitive polymeric nanoparticles for rheumatoid arthritis therapy
    Sample: Plasma
  13. Nanomedicine-Nanotechnology Biology and Medicine (2019) IF: 5.57
    Delivery of siRNA using folate receptor-targeted pH-sensitive polymeric nanoparticles for rheumatoid arthritis therapy

    DOI: 10.1016/j.nano.2019.102017

    PMID: 31128293

    Sample: Plasma
  14. Cellular Physiology and Biochemistry (2017) IF: 5.104
    Bifidobacterium Infantis Ameliorates Chemotherapy-Induced Intestinal Mucositis Via Regulating T Cell Immunity In Colorectal Cancer Rats.

    DOI: 10.1159/000480005

    PMID: 28848081

    Sample: Serum
  15. Cellular Physiology and Biochemistry (2016) IF: 5.104
    Hyperbaric Oxygen Intervention Modulates Early Brain Injury After Experimental Subarachnoid Hemorrhage In Rats: Possible Involvement Of TLR4/NF-κB-Mediated Signaling Pathway.

    DOI: 10.1159/000445586

    PMID: 27197977

    Sample: Tissue homogenate
  16. Journal of Molecular and Cellular Cardiology (2016) IF: 5.68
    Cinnamaldehyde Ameliorates LPS-Induced Cardiac Dysfunction Via TLR4-NOX4 Pathway: The Regulation Of Autophagy And ROS Production.

    DOI: 10.1016/j.yjmcc.2016.10.017

    PMID: 27838370

    Sample: Serum
  17. Cellular and Molecular Life Sciences (2016) IF: 5.788
    Enteric Glial Cells Are Susceptible To Clostridium Difficile Toxin B.

    DOI: 10.1007/s00018-016-2426-4

    PMID: 27891552

    Sample: Cell culture supernatant
  18. Toxicology (2020) IF: 4.099
    Protocatechuic acid modulates reproductive dysfunction linked to furan exposure in rats

    DOI: 10.1016/j.tox.2020.152556

    PMID: 32758512

    Sample: Serum,Tissue homogenate
  19. European Journal of Pharmaceutics and Biopharmaceutics (2020) IF: 4.604
    Study of double-targeting nanoparticles loaded with MCL-1 siRNA and dexamethasone for adjuvant-induced arthritis therapy

    DOI: 10.1016/j.ejpb.2020.07.009

    PMID: 32681961

    Sample: Serum
  20. Biomedicine & Pharmacotherapy (2020) IF: 4.545
    Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role

    DOI: 10.1016/j.biopha.2020.110075

    PMID: 32179202

    Sample: Serum,Tissue homogenate
  21. Aging (2020) IF: 4.831
    Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis

    DOI: 10.18632/aging.103215

    PMID: 32432571

    Sample: Cell culture supernatant,Tissue homogenate
  22. Biomedicine & Pharmacotherapy (2020) IF: 4.545
    Semen Brassicae reduces thoracic aortic remodeling, inflammation, and oxidative damage in spontaneously hypertensive rats

    DOI: 10.1016/j.biopha.2020.110400

    PMID: 32570115

    Sample: Serum
  23. Biomedicine & Pharmacotherapy (2020) IF: 4.545
    Huoxuezhitong capsule ameliorates MIA-induced osteoarthritis of rats through suppressing PI3K/ Akt/ NF-κB pathway

    DOI: 10.1016/j.biopha.2020.110471

    Sample: Serum
  24. Biomedicine & Pharmacotherapy (2020) IF: 4.545
    Tetramethylpyrazine attenuates endotoxin-induced retinal inflammation by inhibiting microglial activation via the TLR4/NF-κB signalling pathway

    DOI: 10.1016/j.biopha.2020.110273

    PMID: 32460188

    Sample: Cell culture supernatant
  25. Biomedicine & Pharmacotherapy (2020) IF: 4.545
    Berberine regulates fecal metabolites to ameliorate 5-fluorouracil induced intestinal mucositis through modulating gut microbiota

    DOI: 10.1016/j.biopha.2020.109829

    PMID: 31958765

    Sample: Tissue homogenate
  26. International Journal of Biological Sciences (2019) IF: 4.858
    Hydrogen sulfide treatment alleviated ventilator-induced lung injury through regulation of autophagy and endoplasmic reticulum stress

    DOI: 10.7150/ijbs.38315

    PMID: 31853224

    Sample: Serum,Bronchoalveolar Lavage Fluid,Tissue homogena
  27. Journal of cellular biochemistry (2019) IF: 4.237
    Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study

    DOI: 10.1002/jcb.28976

    PMID: 31099131

    Sample: Tissue homogenate
  28. Laboratory Investigation (2018) IF: 4.254
    The role of Ca 2+ in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis

    DOI: 10.1038/s41374-018-0135-3

    PMID: 30487596

    Sample: Plasma
  29. Journal of tissue engineering and regenerative medicine (2019) IF: 4.089
    Nanostructured fibrin agarose hydrogel as a novel hemostatic agent

    DOI: 10.1002/term.2831

    PMID: 30793853

    Sample: Plasma
  30. Journal of Ethnopharmacology (2020) IF: 3.69
    COPD rat model is more susceptible to cold stress and PM 2.5 exposure and the underlying mechanism.

    DOI: 10.1016/j.jep.2020.113275

    Sample: Serum
  31. European Journal of Pharmaceutics and Biopharmaceutics (2018) IF: 4.491
    Dual-functional lipid polymeric hybrid pH-responsive nanoparticles decorated with cell penetrating peptide and folate for therapy against rheumatoid arthritis.

    DOI: 10.1016/j.ejpb.2018.06.020

    PMID: 29928978

    Sample: Plasma
  32. Oxidative Medicine and Cellular Longevity (2016) IF: 4.593
    Thioredoxin-Interacting Protein Mediates NLRP3 Inflammasome Activation Involved In The Susceptibility To Ischemic Acute Kidney Injury In Diabetes.

    DOI: 10.1155/2016/2386068

    PMID: 27867451

    Sample: Tissue homogenate
  33. Oxidative Medicine & Cellular Longevity (2015) IF: 4.593
    Polydatin Alleviates Small Intestine Injury During Hemorrhagic Shock As A Sirt1 Activator.

    DOI: 10.1155/2015/965961

    PMID: 26301045

    Sample: Serum
  34. Scientific Reports (2020) IF: 3.998
    The effects of exercise treatment on learning and memory ability, and cognitive performance in diet-induced prediabetes animals

    DOI: 10.1038/s41598-020-72098-0

    PMID: 32929110

    Sample: Tissue homogenate
  35. Journal of Ethnopharmacology (2020) IF: 3.69
    Water extract of Armillaria mellea (Vahl) P. Kumm. Alleviates the depression-like behaviors in acute- and chronic mild stress-induced rodent models via anti-inflammatory action

    DOI: 10.1016/j.jep.2020.113395

    PMID: 32956757

    Sample: Serum,Tissue homogenate
  36. Journal of Ethnopharmacology (2020) IF: 3.69
    Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4/MyD88/NF-κB and TGF-β/smads signaling pathways

    DOI: 10.1016/j.jep.2020.113275

    PMID: 32810620

    Sample: Serum
  37. International Immunopharmacology (2020) IF: 3.943
    Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis

    DOI: 10.1016/j.intimp.2020.106771

    PMID: 32683302

    Sample: Serum
  38. Immunology letters (2020) IF: 3.276
    Protective effect of Ganoderic acid A on adjuvant-induced arthritis

    DOI: 10.1016/j.imlet.2020.06.010

    PMID: 32565114

    Sample: Serum
  39. Environmental Toxicology and Pharmacology (2020) IF: 3.292
    Nicotine-mediated upregulation of microRNA-141 expression determines adipokine-intervened insulin resistance

    DOI: 10.1016/j.etap.2020.103506

    PMID: 33002592

    Sample: Serum
  40. Drug Design, Development and Therapy (2020) IF: 3.216
    Hirudin Protects Against Kidney Damage in Streptozotocin-Induced Diabetic Nephropathy Rats by Inhibiting Inflammation via P38 MAPK/NF-κB Pathway

    DOI: 10.2147/DDDT.S257613

    PMID: 32848363

    Sample: Cell culture supernatant,Tissue homogenate
  41. British Journal of Nutrition (2020) IF: 3.334
    Impact of improving eating habits and rosmarinic acid supplementation on rat vascular and neuronal system in the metabolic syndrome model

    DOI: 10.1017/S000711452000327X

    PMID: 32814604

    Sample: Serum
  42. Mycotoxin Research (2020) IF: 3.164
    Acute aflatoxin B 1-induced gastro-duodenal and hepatic oxidative damage is preceded by time-dependent hyperlactatemia in rats

    DOI: 10.1007/s12550-020-00408-6

    PMID: 32954470

    Sample: Serum
  43. Experimental Biology and Medicine (2020) IF: 3.139
    H 2 S attenuates oxidative stress via Nrf2/NF-κB signaling to regulate restenosis after percutaneous transluminal angioplasty

    DOI: 10.1177/1535370220961038

    PMID: 32996350

    Sample: Plasma
  44. European review for medical and pharmacological sciences (2020) IF: 3.024
    The effect of myocardial infarction-associated transcript 2 (miR-2) and miR-101 on sepsis-induced myocardial injury in rats

    DOI: 10.26355/eurrev_202006_21528

    Sample: Serum
  45. Environmental Science and Pollution Research (2020) IF: 3.056
    Aged garlic extract rescues ethephon-induced kidney damage by modulating oxidative stress, apoptosis, inflammation, and histopathological changes in rats

    DOI: 10.1007/s11356-020-10997-5

    PMID: 33011947

    Sample: Serum
  46. Environmental Science and Pollution Research (2020) IF: 3.056
    Platelet-rich plasma and/or sildenafil topical applications accelerate and better repair wound healing in rats through regulation of proinflammatory cytokines and collagen/TGF-β1 pathway

    DOI: 10.1007/s11356-020-10042-5

    PMID: 32671702

    Sample: Serum
  47. Cell Cycle (2020) IF: 3.699
    Knockdown of circular RNA circMAT2B reduces oxygen-glucose deprivation-induced inflammatory injury in H9c2 cells through up-regulating miR-133

    DOI: 10.1080/15384101.2020.1814025

    PMID: 32897801

    Sample: Cell culture supernatant
  48. Mediators of Inflammation (2020) IF: 3.758
    Exposure to Air Pollution Exacerbates Inflammation in Rats with Preexisting COPD

    DOI: 10.1155/2020/4260204

    PMID: 32454790

    Sample: Tissue homogenate,Bronchoalveolar Lavage Fluid
  49. Journal of Ethnopharmacology (2020) IF: 3.69
    Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways

    DOI: 10.1016/j.jep.2020.113039

    PMID: 32497675

    Sample: Serum,Cell culture supernatant
  50. Environmental Toxicology (2020) IF: 3.118
    Cadmium and nickel co-exposure exacerbates genotoxicity and not oxido-inflammatory stress in liver and kidney of rats: Protective role of omega-3 fatty acid

    DOI: 10.1002/tox.22860

    PMID: 31639282

    Sample: Tissue homogenate
  51. International Immunopharmacology (2020) IF: 3.943
    Klotho ameliorates the onset and progression of cataract via suppressing oxidative stress and inflammation in the lens in streptozotocin-induced diabetic rats

    DOI: 10.1016/j.intimp.2020.106582

    PMID: 32438076

    Sample: Plasma
  52. European Review for Medical and Pharmacological Sciences (2020) IF: 3.024
    Overexpression of HOXA-AS2 inhibits inflammation and apoptosis in podocytes via sponging miR-A-302b-3p to upregulate TIMP3

    DOI: 10.26355/eurrev_202005_21187

    PMID: 32432759

    Sample: Serum
  53. European Review for Medical and Pharmacological Sciences (2020) IF: 3.024
    Curcumin exerts protective effect on PC12 cells against lidocaine-induced cytotoxicity by suppressing the formation of NLRP3 inflammasome

    DOI: 10.26355/eurrev_202006_21703

    PMID: 32633404

    Sample: Cell culture supernatant
  54. Inflammation (2020) IF: 3.212
    Nobiletin Protects from Renal Ischemia-Reperfusion Injury in Rats by Suppressing Inflammatory Cytokines and Regulating iNOS-eNOS Expressions

    DOI: 10.1007/s10753-019-01123-w

    PMID: 31705353

    Sample: Serum
  55. Annals of Translational Medicine (2020) IF: 3.297
    Palmitic acid stimulates NLRP3 inflammasome activation through TLR4-NF-κB signal pathway in hepatic stellate cells

    DOI: 10.21037/atm.2020.02.21

    PMID: 32309315

    Sample: Serum,Cell culture supernatant,Tissue homogenate
  56. International Immunopharmacology (2020) IF: 3.943
    The ameliorating effect of cannabinoid type 2 receptor activation on brain, lung, liver and heart damage in cecal ligation and puncture-induced sepsis model in rats

    DOI: 10.1016/j.intimp.2019.105978

    PMID: 31767546

    Sample: Tissue homogenate
  57. NeuroToxicology (2020) IF: 3.105
    Neuroprotective mechanisms of selenium against arsenic-induced behavioral impairments in rats

    DOI: 10.1016/j.neuro.2019.10.009

    PMID: 31678059

    Sample: Tissue homogenate
  58. European Journal of Pharmacology (2019) IF: 3.263
    Associations of inflammatory markers and vascular cell adhesion molecule-1 with endothelial dysfunction in collagen-induced arthritis

    DOI: 10.1016/j.ejphar.2019.172786

    PMID: 31712060

    Sample: Serum
  59. Neuroscience (2018) IF: 3.056
    Inhibiting Succinate Dehydrogenase by Dimethyl Malonate Alleviates Brain Damage in a Rat Model of Cardiac Arrest

    DOI: 10.1016/j.neuroscience.2018.09.041

    PMID: 30300703

    Sample: Serum
  60. Inflammopharmacology (2018) IF: 3.304
    SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy

    DOI: 10.1007/s10787-018-0522-9

    PMID: 30094758

    Sample: Tissue homogenate
  61. Journal of cellular physiology (2019) IF: 3.923
    8-Br-cADPR, a TRPM2 Ion Channel Antagonist, Inhibits Renal Ischemia-Reperfusion Injury

    DOI: 10.1002/jcp.27236

    PMID: 30191993

    Sample: Plasma
  62. Frontiers in pharmacology (2018) IF: 3.831
    PSTPIP2 inhibits the inflammatory response and proliferation of fibroblast-like synoviocytes in vitro

    DOI: 10.3389/fphar.2018.01432

    PMID: 30564127

    Sample: Serum,Cell culture supernatant
  63. Molecules (2019) IF: 3.098
    Hyaluronic Acid Coated Acid-Sensitive Nanoparticles for Targeted Therapy of Adjuvant-Induced Arthritis in Rats

    DOI: 10.3390/molecules24010146

    PMID: 30609724

    Sample: Serum
  64. Molecules (2019) IF: 3.098
    Plant-Derived Oleanolic Acid (OA) Ameliorates Risk Factors of Cardiovascular Diseases in a Diet-Induced Pre-Diabetic Rat Model: Effects on Selected Cardiovascular Risk Factors

    DOI: 10.3390/molecules24020340

    PMID: 30669379

    Sample: Plasma,Tissue homogenate
  65. Journal of Trace Elements in Medicine and Biology (2019) IF: 3.755
    Rutin abrogates manganese - induced striatal and hippocampal toxicity via inhibition of iron depletion, oxidative stress, inflammation and suppressing the NF-κB signaling pathway

    DOI: 10.1016/j.jtemb.2019.01.014

    PMID: 30910212

    Sample: Tissue homogenate
  66. Life sciences (2019) IF: 3.234
    Myocardial caspase-3 and NF-κB activation promotes calpain-induced septic apoptosis: The role of Akt/eNOS/NO pathway

    DOI: 10.1016/j.lfs.2019.02.048

    PMID: 30807754

    Sample: Serum,Tissue homogenate
  67. Journal of Cellular Physiology (2019) IF: 3.923
    C1q/TNF-related protein-9 promotes macrophage polarization and improves cardiac dysfunction after myocardial infarction

    DOI: 10.1002/jcp.28513

    PMID: 30953351

    Sample: Tissue homogenate
  68. International Immunopharmacology (2019) IF: 3.361
    Inhibition of macrophage migration inhibitory factor attenuates inflammation and fetal kidney injury in a rat model of acute pancreatitis in pregnancy

    DOI: 10.1016/j.intimp.2018.12.068

    PMID: 30622028

    Sample: Serum
  69. Am J Physiol Gastrointest Liver Physiol (2018) IF: 3.293
    Inhibition of endoplasmic reticulum stress by 4-phenylbutyric acid prevents vital organ injury in rat acute pancreatitis

    DOI: 10.1152/ajpgi.00102.2018

    PMID: 30138574

    Sample: Serum
  70. Inflammopharmacology (2018) IF: 3.304
    SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy

    DOI: 10.1007/s10787-018-0522-9

    PMID: 30094758

    Sample: Serum
  71. Toxins (2018) IF: 3.273
    The Protective Role of Bacillus velezensis A2 on the Biochemical and Hepatic Toxicity of Zearalenone in Mice.

    DOI: 10.3390/toxins10110449

    PMID: 30384460

    Sample: Serum, Tissue homogenate
  72. Biomedicine & Pharmacotherapy (2018) IF: 3.457
    Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity.

    DOI: 10.1016/j.biopha.2018.07.081

    PMID: 30119204

    Sample: Serum
  73. Molecular Immunology (2018) IF: 3.236
    The Protective Effect Of Dexmedetomidine On LPS-Induced Acute Lung Injury Through The HMGB1-Mediated TLR4/NF-κB And PI3K/Akt/mTOR Pathways.

    DOI: 10.1016/j.molimm.2017.12.008

    PMID: 29241031

    Sample: Bronchoalveolar Lavage Fluid,Serum,Tissue homogena
  74. Phytotherapy Research (2017) IF: 3.092
    Scopoletin-standardized Morinda Elliptica Leaf Extract Suppressed Inflammation And Cartilage Degradation To Alleviate Osteoarthritis: A preclinical Study.

    DOI: 10.1002/ptr.5949

    PMID: 29067744

    Sample: Serum
  75. Basic & Clinical Pharmacology & Toxicology (2016) IF: 3.176
    Small Molecule Inhibiting NF-κB Ameliorates Oxidative Stress And Suppresses Renal Inflammation In Early Stage Of Alloxan-Induced Diabetic Nephropathy In Rat.

    DOI: 10.1111/bcpt.12718

    PMID: 27888584

    Sample: Tissue homogenate
  76. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy (2020) IF: 2.842
    Activation of Nrf2 Signaling by Apelin Attenuates Renal Ischemia Reperfusion Injury in Diabetic Rats

    DOI: 10.2147/DMSO.S246743

    PMID: 32606875

    Sample: Serum
  77. Toxin Reviews (2020) IF: 2.851
    Nicotine lowers TNF-α, IL-1b secretion and leukocyte accumulation via nAChR in rat stomach

    DOI: 10.1080/15569543.2020.1790604

    Sample: Tissue homogenate
  78. Therapeutic Advances in Endocrinology and Metabolism (2020) IF: 2.173
    Plant-derived oleanolic acid ameliorates markers of subclinical inflammation and innate immunity activation in diet-induced pre-diabetic rats

    DOI: 10.1177/2042018820935771

    PMID: 32782775

    Sample: Plasma
  79. Molecular Medicine Reports (2020) IF: 2.1
    Pretreatment with the ALDH2 activator Alda-1 protects rat livers from ischemia/reperfusion injury by inducing autophagy

    DOI: 10.3892/mmr.2020.11312

    PMID: 32705206

    Sample: Serum
  80. Journal of the Science of Food and Agriculture (2020) IF: 2.614
    Tiliacora triandra extract and its major constituent attenuates diabetic kidney and testicular impairment by modulating redox imbalance and pro-inflammatory responses in rats

    DOI: 10.1002/jsfa.10779

    PMID: 32875596

    Sample: Tissue homogenate
  81. Experimental Physiology (2020) IF: 2.431
    Combination of quercetin and exercise training attenuates depression in rats with 1,2-dimethylhydrazine-induced colorectal cancer: Possible involvement of inflammation and BDNF signalling

    DOI: 10.1113/EP088605

    PMID: 32681548

    Sample: Serum,Tissue homogenate
  82. Cell Biology International (2020) IF: 2.571
    Acid-sensing ion channel 1a mediates acid-induced pyroptosis through calpain-2/calcineurin pathway in rat articular chondrocytes

    DOI: 10.1002/cbin.11422

    PMID: 32678496

    Sample: Cell culture supernatant
  83. Molecular Medicine Reports (2020) IF: 2.1
    Troxerutin attenuates oxygen-glucose deprivation and reoxygenation-induced oxidative stress and inflammation by enhancing the PI3K/AKT/HIF-1α signaling pathway in H9C2 cardiomyocytes

    DOI: 10.3892/mmr.2020.11207

    PMID: 32626962

    Sample: Cell culture supernatant
  84. Toxicology Research (2020) IF: 2.283
    The effects of phenanthrene exposure on Treg and Th17 cells related cytokines in female rats

    DOI: 10.1093/toxres/tfaa030

    PMID: 32670559

    Sample: Tissue homogenate
  85. Clinical Rheumatology (2020) IF: 2.394
    Investigation of the efficacy of daidzein in experimental knee osteoarthritis-induced with monosodium iodoacetate in rats

    DOI: 10.1007/s10067-020-04958-z

    PMID: 32103372

    Sample: Serum
  86. FEBS Open bio (2020) IF: 2.231
    ASIC1a inhibits cell pyroptosis induced by acid‐induced activation of rat hepatic stellate cells

    DOI: 10.1002/2211-5463.12850

    PMID: 32237041

    Sample: Cell culture medium
  87. Radiation Oncology (2020) IF: 2.817
    Hippocampal changes in inflammasomes, apoptosis, and MEMRI after radiation-induced brain injury in juvenile rats

    DOI: 10.1186/s13014-020-01525-3

    PMID: 32276638

    Sample: Tissue homogenate
  88. PloS one (2020) IF: 2.74
    Associations of inflammatory markers with impaired left ventricular diastolic and systolic function in collagen-induced arthritis

    DOI: 10.1371/journal.pone.0230657

    PMID: 32208438

    Sample: Serum
  89. Future Microbiology (2020) IF: 2.907
    The anti-inflammatory, anti-oxidant and protective effects of a probiotic mixture on organ toxicity in a rat model

    DOI: 10.2217/fmb-2020-0005

    PMID: 32250184

    Sample: Serum
  90. Bioscience reports (2019) IF: 2.942
    Up-regulated MCPIP1 in abdominal aortic aneurysm is associated with vascular smooth muscle cell apoptosis and MMPs production

    DOI: 10.1042/BSR20191252

    PMID: 31651935

    Sample: Serum,Plasma,Cell sample
  91. RSC Advances (2019) IF: 2.936
    Morroniside alleviates coxsackievirus B3-induced myocardial damage apoptosis via restraining NLRP3 inflammasome activation

    DOI: 10.1039/C8RA08662A

    Sample: Tissue homogenate
  92. Journal of Neuroimmunology (2019) IF: 2.655
    The role of UCH-L1, MMP-9, and GFAP as peripheral markers of different susceptibility to seizure development in a preclinical model of epilepsy

    DOI: 10.1016/j.jneuroim.2019.03.018

    PMID: 30952062

    Sample: Plasma
  93. American Journal of Reproductive Immunology (2019) IF: 2.745
    Nisin Reduces Uterine Inflammation in Rats by Modulating Concentrations of Pro- And Anti-Inflammatory Cytokines

    DOI: 10.1111/aji.13096

    PMID: 30681748

    Sample: Serum
  94. Bioscience reports (2018) IF: 2.899
    Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats

    DOI: 10.1042/BSR20180892

    PMID: 30232232

    Sample: Tissue homogenate
  95. Biochemical and biophysical research communications (2018) IF: 2.559
    Serum thyroid hormones levels are significantly decreased in pregnant rats with acute pancreatitis

    DOI: 10.1016/j.bbrc.2018.09.180

    PMID: 30286956

    Sample: Serum
  96. Journal of cellular biochemistry (2019) IF: 2.959
    Exosomes derived from miR-146a-modified adipose- derived stem cells attenuate acute myocardial infarction- induced myocardial damage via downregulation of early growth response factor 1

    DOI: 10.1002/jcb.27731

    PMID: 30362610

    Sample: Serum,Cell culture supernatant
  97. Journal of diabetes research (2019) IF: 2.885
    Lipopolysaccharide (LPS) Aggravates High Glucose-and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes

    DOI: 10.1155/2019/8151836

    PMID: 30911553

    Sample: Cell culture supernatant
  98. BioMed Research International (2019) IF: 2.197
    Galangin Suppresses Renal Inflammation via the Inhibition of NF-κB, PI3K/AKT and NLRP3 in Uric Acid Treated NRK-52E Tubular Epithelial Cells

    DOI: 10.1155/2019/3018357

    PMID: 31240210

    Sample: Cell culture supernatant
  99. Neuroscience Letters (2018) IF: 2.159
    Rutin Attenuates Neurobehavioral Deficits, Oxidative Stress, Neuro-Inflammation and Apoptosis in Fluoride Treated Rats.

    DOI: 10.1016/j.neulet.2018.06.023

    PMID: 29908257

    Sample: Tissue homogenate
  100. Biochemical And Biophysical Research Communications (2017) IF: 2.466
    Umbilical Cord-Derived Mesenchymal Stem Cells Alleviated Inflammation And Inhibited Apoptosis In Interstitial Cystitis Via AKT/mTOR Signaling Pathway.

    DOI: 10.1016/j.bbrc.2017.11.072

    PMID: 29137981

    Sample: Tissue homogenate
  101. Inflammation Research (2015) IF: 2.659
    Effect Of Retinoic Acid On The Function Of Lipopolysaccharide-Stimulated Bone Marrow Stromal Cells Grown On Titanium Surfaces.

    DOI: 10.1007/s00011-014-0784-7

    PMID: 25403801

    Sample: Cell culture supernatant
  102. Journal of Ethnopharmacology (2017) IF: 2.981
    Renoprotective And Antioxidative Effects Of Methanolic Paederia Foetida Leaf Extract On Experimental Diabetic Nephropathy In Rats.

    DOI: 10.1016/j.jep.2017.01.035

    PMID: 28111217

    Sample: Serum,Tissue homogenate
  103. European Journal of Pharmacology (2016) IF: 2.896
    The Protective Role Of Neuregulin-1: A Potential Therapy For Sepsis-Induced Cardiomyopathy.

    DOI: 10.1016/j.ejphar.2016.06.042

    PMID: 27346832

    Sample: Serum
  104. Plos One (2015) IF: 2.806
    Extracellular Vesicles Derived From Bone Marrow Mesenchymal Stem Cells Protect Against Experimental Colitis Via Attenuating Colon Inflammation, Oxidative Stress And Apoptosis.

    DOI: 10.1371/journal.pone.0140551

    PMID: 26469068

    Sample: Tissue homogenate
  105. Plos One (2015) IF: 2.806
    Osteoprotective Effect Of Echinocystic Acid, A Triterpone Component From Eclipta Prostrata, In Ovariectomy-Induced Osteoporotic Rats.

    DOI: 10.1371/journal.pone.0136572

    PMID: 26317835

    Sample: Serum
  106. Plos One (2015) IF: 2.806
    Transplantation Of Induced Pluripotent Stem Cells Alleviates Cerebral Inflammation And Neural Damage In Hemorrhagic Stroke.

    DOI: 10.1371/journal.pone.0129881

    PMID: 26086994

    Sample: Tissue homogenate
  107. Journal of Ethnopharmacology (2016) IF: 2.981
    Venenum Bufonis Induces Rat Neuroinflammation By Activiating NF-κB Pathway And Attenuation Of BDNF.

    DOI: 10.1016/j.jep.2016.03.049

    PMID: 27013094

    Sample: Tissue homogenate
  108. The Korean Journal of Physiology & Pharmacology: Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology (2020) IF: 1.805
    The hepato-protective effect of eupatilin on an alcoholic liver disease model of rats

    DOI: 10.4196/kjpp.2020.24.5.385

    PMID: 32830145

    Sample: Tissue homogenate
  109. International urology and nephrology (2020) IF: 1.843
    Vinpocetine reduces cisplatin-induced acute kidney injury through inhibition of NF-κB pathway and activation of Nrf2/ARE pathway in rats

    DOI: 10.1007/s11255-020-02485-z

    PMID: 32418008

    Sample: Serum,Urine,Tissue homogenate
  110. Journal of International Medical Research (2019) IF: 1.287
    Electroacupuncture reduces astrocyte number and oxidative stress in aged rats with surgery-induced cognitive dysfunction

    DOI: 10.1177/0300060519860026

    PMID: 31311378

    Sample: Serum
  111. Annals of Surgical Treatment and Research (2019) IF: 1.367
    Examination of Protective and Therapeutic Effects of Ruscogenin on Cerulein-Induced Experimental Acute Pancreatitis in Rats

    DOI: 10.4174/astr.2019.97.6.271

    PMID: 31824881

    Sample: Serum,Tissue homogenate
  112. Experimental and therapeutic medicine (2018) IF: 1.41
    Protective effect of dexpanthenol against cisplatin-induced hepatotoxicity

    DOI: 10.3892/etm.2018.6683

    PMID: 30402149

    Sample: Tissue homogenate
  113. Journal of Food Biochemistry (2019) IF: 1.552
    Epicatechin and scopoletin rich Morinda citrifolia (Noni) leaf extract supplementation, mitigated Osteoarthritis via anti-inflammatory, anti-oxidative, and anti-protease pathways

    DOI: 10.1111/jfbc.12755

    PMID: 31353568

    Sample: Serum
  114. Journal of biochemical and molecular toxicology (2019) IF: 1.837
    Fluoride and diethylnitrosamine coexposure enhances oxido-inflammatory responses and caspase-3 activation in liver and kidney of adult rats

    DOI: 10.1002/jbt.22327

    PMID: 30920066

    Sample: Serum
  115. Renal failure (2019) IF: 1.44
    The aqueous extract of aged black garlic ameliorates colistin-induced acute kidney injury in rats

    DOI: 10.1080/0886022X.2018.1561375

    PMID: 30714460

    Sample: Tissue homogenate
  116. Molecular Medicine Reports (2018) IF: 1.922
    C5a aggravates dysfunction of the articular cartilage and synovial fluid in rats with knee joint immobilization.

    DOI: 10.3892/mmr.2018.9208

    PMID: 29956782

    Sample: Synovial fluid,Tissue homogenate
  117. Experimental and Therapeutic Medicine (2017) IF: 1.261
    Tocotrienol Alleviates Inflammation And Oxidative Stress In A Rat Model Of Spinal Cord Injury Via Suppression Of Transforming Growth Factor-β.

    DOI: 10.3892/etm.2017.4505

    PMID: 28672950

    Sample: Serum
  118. Toxicology Research (2017) IF: 1.969
    Nano NIO Induced Liver Toxicity Via Activating The NF-κB Signaling Pathway In Rats.

    DOI: 10.1039/c6tx00444j

    PMID: 30090495

    Sample: Tissue homogenate
  119. Molecular Medicine Reports (2015) IF: 1.692
    Asiaticoside Attenuates The Effects Of Spinal Cord Injury Through Antioxidant And AntiInflammatory Effects, And Inhibition Of The p38MAPK Mechanism.

    DOI: 10.3892/mmr.2015.4425

    PMID: 26458544

    Sample: Serum
  120. Immunopharmacology & Immunotoxicology (2016) IF: 1.475
    Anti-Oxidant And Anti-Inflammatory Effects Of Apigenin In A Rat Model Of Sepsis: An Immunological, Biochemical, And Histopathological Study.

    DOI: 10.3109/08923973.2016.1173058

    PMID: 27144896

    Sample: Serum
  121. European Journal of Neuroscience (2021) IF: 3.115
    Fecal microbiota transplantation ameliorates gut microbiota imbalance and intestinal barrier damage in rats with stress-induced depressive-like behavior

    DOI: 10.1111/ejn.15192

    PMID: 33742731

    Sample: Serum,Tissue homogenate
  122. Journal of Psychiatric Research (2021) IF: 3.745
    Fecal microbiota transplantation ameliorates stress-induced depression-like behaviors associated with the inhibition of glial and NLRP3 inflammasome in rat brain

    DOI: 10.1016/j.jpsychires.2021.02.057

    PMID: 33677218

    Sample: Tissue homogenate
  123. Journal of Ethnopharmacology (2020) IF: 3.69
    Fructuse water extract attenuates liver fibrosis via TLR4/MyD88/NF-κB and TGF-β/smads signaling pathways

    DOI: 10.1016/j.jep.2020.113275

    Sample: Serum
  124. Journal of Inflammation Research (2020)
    Pharmacological Inhibition of Galectin-3 Ameliorates Diabetes-Associated Cognitive Impairment, Oxidative Stress and Neuroinflammation in vivo and in vitro

    DOI: 10.2147/JIR.S273858

    PMID: 32982368

    Sample: Cell culture supernatant,Tissue homogenate
  125. Journal of Family and Reproductive Health (2020)
    Protective effect of exogenous hydrogen sulfide on diaphragm muscle fibrosis in streptozotocin-induced diabetic rats

    DOI: 10.1177/1535370220931038

    PMID: 32493122

    Sample: Tissue homogenate
  126. Daru: journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2020)
    Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model

    DOI: 10.1007/s40199-020-00343-y

    PMID: 32388789

    Sample: Serum
  127. Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian J Pharm (2020)
    Myricetin Ameliorates Brain Damage Induces by Cerebral Ischemia-Reperfusion Injury in Rats

    DOI: 10.22377/ajp.v14i1.3474

    Sample: Tissue homogenate
  128. Medicinal Plant (2017)
    Protection of Dicliptera chinensis Polysaccharide Granule on Acute Liver Injury of Rat Caused by D-galactosamine
    Sample: Serum,Tissue Slice
  129. Eastern Anatolian Journal of Science (2020)
    The Possible Beneficial Effects of Lazaroid U-74389G on Ovarian Injury
    Sample: Tissue homogenate
  130. New Trends in Medicine Sciences (2020)
    Role of Hyperoside on Ovarian Tissue Damage Created by Ovarian Torsion Detorsion
    Sample: Tissue homogenate
  131. New Trends in Medicine Sciences (2020)
    Role of 6-Shogaol Against Ovarian Torsion Detorsion-Induced Reproductive Organ Damage
    Sample: Tissue homogenate
  132. The Egyptian Journal of Forensic Sciences and Applied Toxicology (2020)
    Sample: Plasma
  133. Adv. Anim. Vet. Sci (2020)
    Ameliorative potential of coconut water in overfed male broiler breeders

    DOI: 10.17582/journal.aavs/2020/

    Sample: Serum
  134. Preprint (2020)
    Therapeutic effects of different treatment periods against ischemic stroke and toxicology study of Angong Niuhuang Pill in rats

    DOI: 10.21203/rs.2.21991/v2

    Sample: Serum,Tissue homogenate
  135. Journal of Experimental Pharmacology (2020)
    Alpha-Mangostin Improves Cardiac Hypertrophy and Fibrosis and Associated Biochemical Parameters in High-Fat/High-Glucose Diet and Low-Dose Streptozotocin Injection-Induced Type 2 Diabetic Rats

    DOI: 10.2147/JEP.S233111

    PMID: 32095085

    Sample: Tissue homogenate
  136. Borneo Journal of Pharmacy (2020)
    Level of Cytokine Interleukin-6 and Interleukin 1-β on Infectious Rat Model Treated with Etlingera elatior (Jack) RM Smith Fruit Extract as Immunomodulator

    DOI: 10.33084/bjop.v3i2.1318

    Sample: Plasma
  137. Pharmacology and Clinical Pharmacy Research (2019)
    Anti-Inflammatory Activity of Marine Sponge Aaptos sp. to the Plasma Interleukin-1β Level in Wistar Male Rats

    DOI: 10.15416/pcpr.v4i2.24269

    Sample: Plasma
  138. Pathology-Research and Practice (2018)
    miR-93-3p alleviates lipopolysaccharide-induced inflammation and apoptosis in H9c2 cardiomyocytes by inhibiting toll-like receptor 4

    DOI: 10.1016/j.prp.2018.08.024

    PMID: 30195636

    Sample: Cell culture supernatant
  139. Iraqi Journal of Pharmaceutical Sciences (2018)
    Effects of Vitamin E and Q10 Supplementation against Doxorubicin-Induced Neurotoxicity in Rats

    DOI: 10.31351/vol27iss2pp24-31

    Sample: Tissue homogenate
  140. Kobe Journal of Medical Sciences (2018)
    Anti-inflammatory Effects of Hibiscus Sabdariffa Linn. on the IL-1β/IL-1ra Ratio in Plasma and Hippocampus of Overtrained Rats and Correlation with Spatial Memory

    PMID: 30381729

    Sample: Plasma,Tissue homogenate
  141. Toxicology Reports (2019)
    Manganese suppresses oxidative stress, inflammation and caspase-3 activation in rats exposed to chlorpyrifos

    DOI: 10.1016/j.toxrep.2019.02.007

    PMID: 30859069

    Sample: Tissue homogenate
  142. bioRxiv (2018) IF: /
    Autophagy Decreases Alveolar Epithelial Cell Injury by Suppressing the NF-κB Signaling Pathway and Regulating the Release of Inflammatory Mediators.

    DOI: 10.1101/328039

    Sample: Tissue homogenate
  143. Acta Cirurgica Brasileira (2017) IF: 0.729
    Dexmedetomidine Protects Against Renal Ischemia And Reperfusion Injury By Inhibiting The P38-MAPK/TXNIP Signaling Activation In Streptozotocin Induced Diabetic Rats.

    DOI: 10.1590/s0102-865020170060000003

    PMID: 28700004

    Sample: Serum,Plasma
  144. Renal Failure (2016) IF: 0.79
    Effect Of Apelin Hormone On Renal Ischemia/Reperfusion Induced Oxidative Damage In Rats.

    DOI: 10.1080/0886022X.2016.1184957

    PMID: 27197832

    Sample: Serum
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