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Rat IL-6(Interleukin 6) ELISA Kit

  • Cat.No.:E-EL-R0015

  • Reactivity: Rat

To Purchase E-EL-R0015

Size:
  • 96T
  • 48T
  • 24T
  • 96T*5
  • 96T*10
Price: $495
Qty:

Product Details

Properties

Assay type Sandwich-ELISA
Format 96T/48T
Assay time 3.5h
Detection range 12.50-800 pg/mL
Sensitivity 7.50 pg/mL
Sample type &Sample volume serum, plasma and other biological fluids; 100μL
Specificity This kit recognizes Rat IL-6 in samples. No significant cross-reactivity or interference between Rat IL-6 and analogues was observed.
Reproducibility Both intra-CV and inter-CV are < 10%.
Application This ELISA kit applies to the in vitro quantitative determination of Rat IL-6 concentrations in serum, plasma and other biological fluids.

Test Principle

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat IL-6. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Rat IL-6 and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Rat IL-6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of Rat IL-6. You can calculate the concentration of Rat IL-6 in the samples by comparing the OD of the samples to the standard curve.

Kit components & Storage

An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the components separately according to the following conditions once the kit is received.
ItemSpecificationsStorage
Micro ELISA Plate(Dismountable) 96T: 8 wells ×12 strips
48T: 8 wells ×6 strips
-20℃, 6 months
Reference Standard 96T: 2 vials
48T: 1 vial
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
-20℃(Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL
HRP Conjugate Diluent 1 vial, 14 mL
Concentrated Wash Buffer (25×) 1 vial, 30 mL
Substrate Reagent 1 vial, 10 mL 2-8℃(Protect from light)
Stop Solution 1 vial, 10 mL 2-8°C
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Technical Data

Precision

Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Rat IL-6 were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Rat IL-6 were tested on 3 different plates, 20 replicates in each plate.

  Intra-assay Precision Inter-assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (pg/mL) 34.58 93.20 396.79 34.39 95.73 379.80
Standard deviation 2.04 4.50 19.96 1.75 4.79 18.61
CV (%) 5.90 4.83 5.03 5.09 5.00 4.90

Recovery

The recovery of Rat IL-6 spiked at three different levels in samples throughout the range of the assay was evaluated in various matrices.

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 98-111 105
EDTA plasma (n=8) 95-109 102
Cell culture media (n=8) 89-95 92

Linearity

Samples were spiked with high concentrations of Rat IL-6 and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

Target Information

Database LinksSwissProt: P20607
SynonymsIL6, BSF2, HGF, HSF, IFNB2, CDF
Research AreaCancer,Neuroscience

Assay Procedures

elisa assay procedure 1

1. Add 100μL standard or sample to the wells. Incubate for 90 min at 37°C

elisa assay procedure 2

2. Discard the liquid, immediately add 100μL Biotinylated Detection Ab working solution to each well. Incubate for 60 min at 37°C

elisa assay procedure 3

3. Aspirate and wash the plate for 3 times

elisa assay procedure 4

4. Add 100μL HRP conjugate working solution. Incubate for 30 min at 37°C. Aspirate and wash the plate for 5 times

elisa assay procedure 5

5. Add 90μL Substrate Reagent. Incubate for 15 min at 37°C

elisa assay procedure 6

6. Add 50μL Stop Solution

elisa assay procedure 7

7. Read the plate at 450nm immediately. Calculation of the results

Related Products

Elabscience® provides ancillary reagents required for ELISA kit developments.11 reagents in total, including reagents for coating, blocking, washing, improving the stability and reducing matrix interference etc.
Cat.No. Product Name Specifications
E-ELIR-001 ELISA Plate Coating Buffer(1×) 100mL, 1000mL
E-ELIR-002 ELISA Plate Coating Buffer(5×) 100mL, 1000mL
E-ELIR-003 ELISA Plate Blocking Buffer 100mL, 1000mL
E-ELIR-004 Wash Buffer for Sandwich-ELISA(25×) 100mL, 1000mL
E-ELIR-005 Wash Buffer for Competitive-ELISA(25×) 100mL, 1000mL
E-ELIR-006 Stop Solution 100mL, 1000mL
E-ELIR-007 HRP-conjugate Stabilizer 10mL, 100mL, 500mL
E-ELIR-008 HRP-conjugate Diluent 100mL, 1000mL
E-ELIR-009 Biotinylated Antibody Stabilizer 10mL, 100mL, 500mL
E-ELIR-0010 Biotinylated Antibody Diluent 10mL, 100mL, 500mL
E-ELIR-0011 Sample Diluent 10mL, 100mL, 500mL

Citations

From now on, if you have published a paper by using any of our products since 1/1/2019, fill out the “Elabscience Publication Reward Application Form”carefully and send it to orders@elabscience.com, we will get back to you with the reward after we confirm it ASAP!

View more details about our Publication Reward >>

  1. British journal of pharmacology (2018) IF: 6.81
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    DOI: 10.1111/bph.14500

    PMID: 30221753

    Sample: Serum
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    DOI: 10.1155/2020/1720961

    PMID: 32765805

    Sample: Serum,Tissue homogenate
  3. Translational Stroke Research (2020) IF: 5.78
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    DOI: 10.1007/s12975-019-00715-w

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  4. International journal of biological macromolecules (2020) IF: 5.162
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    DOI: 10.1016/j.ijbiomac.2019.09.219

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    DOI: 99999999

    PMID: 99999999

    Sample: Serum
  6. IF: 5.57
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    Sample: Plasma
  7. Nanomedicine-Nanotechnology Biology and Medicine (2019) IF: 5.57
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    DOI: 10.1016/j.nano.2019.102017

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    Sample: Plasma
  8. The FASEB Journal (2018) IF: 5.595
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    DOI: 10.1096/fj.201800028RR

    PMID: 29870680

    Sample: Tissue homogenate
  9. Cellular Physiology and Biochemistry (2017) IF: 5.104
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    DOI: 10.1159/000480005

    PMID: 28848081

    Sample: Serum
  10. Cellular Physiology and Biochemistry (2016) IF: 5.104
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    DOI: 10.1159/000445586

    PMID: 27197977

    Sample: Tissue homogenate
  11. Journal of Molecular and Cellular Cardiology (2016) IF: 5.68
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    DOI: 10.1016/j.yjmcc.2016.10.017

    PMID: 27838370

    Sample: Serum
  12. Molecular Pharmaceutics (2020) IF: 4.32
    Accelerated Blood Clearance of Nanoemulsions Modified with PEG- Cholesterol and PEG-Phospholipid Derivatives in Rats: The Effect of PEG-Lipid Linkages and PEG Molecular Weights

    DOI: 10.1021/acs.molpharmaceut.9b00770

    PMID: 99999999

    Sample: Plasma,Tissue homogenate
  13. European Journal of Pharmaceutics and Biopharmaceutics (2020) IF: 4.604
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    DOI: 10.1016/j.ejpb.2020.07.009

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    Sample: Serum
  14. Biomedicine & Pharmacotherapy (2020) IF: 4.545
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    DOI: 10.1016/j.biopha.2020.110400

    PMID: 32570115

    Sample: Serum
  15. Ecotoxicology and Environmental Safety (2020) IF: 4.872
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    DOI: 10.1016/j.ecoenv.2019.110065

    PMID: 31869719

    Sample: Tissue homogenate
  16. Biomedicine & Pharmacotherapy (2020) IF: 4.545
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    DOI: 10.1016/j.biopha.2020.110273

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    Sample: Cell culture supernatant
  17. Biomedicine & Pharmacotherapy (2020) IF: 4.545
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    DOI: 10.1016/j.biopha.2020.109829

    PMID: 31958765

    Sample: Tissue homogenate
  18. Frontiers in Pharmacology (2020) IF: 4.225
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    DOI: 10.3389/fphar.2020.00687

    PMID: 32508639

    Sample: Tissue homogenate
  19. Molecular Pharmaceutics (2019) IF: 4.321
    Accelerated Blood Clearance of Nanoemulsions Modified with PEG-Cholesterol and PEG-Phospholipid Derivatives in Rats: The Effect of PEG-Lipid Linkages and PEG Molecular Weights

    DOI: 10.1021/acs.molpharmaceut.9b00770

    PMID: 31860321

    Sample: Serum
  20. International Journal of Biological Sciences (2019) IF: 4.858
    Hydrogen sulfide treatment alleviated ventilator-induced lung injury through regulation of autophagy and endoplasmic reticulum stress

    DOI: 10.7150/ijbs.38315

    PMID: 31853224

    Sample: Serum,Bronchoalveolar Lavage Fluid,Tissue homogena
  21. Journal of cellular biochemistry (2019) IF: 4.237
    Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study

    DOI: 10.1002/jcb.28976

    PMID: 31099131

    Sample: Tissue homogenate
  22. Neurobiology of aging (2019) IF: 4.454
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    DOI: 10.1016/j.neurobiolaging.2018.11.023

    PMID: 30594047

    Sample: Tissue homogenate,Cell culture medium
  23. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease (2019) IF: 4.328
    Inflammation-dependent ISG15 upregulation mediates MIA-induced dendrite damages and depression by disrupting NEDD4/Rap2A signaling

    DOI: 10.1016/j.bbadis.2019.02.020

    PMID: 30826466

    Sample: Serum
  24. Oxidative Medicine and Cellular Longevity (2018) IF: 4.936
    Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways.

    DOI: 10.1155/2018/9647809

    PMID: 29977458

    Sample: Cells
  25. European Journal of Pharmaceutics and Biopharmaceutics (2018) IF: 4.491
    Dual-functional lipid polymeric hybrid pH-responsive nanoparticles decorated with cell penetrating peptide and folate for therapy against rheumatoid arthritis.

    DOI: 10.1016/j.ejpb.2018.06.020

    PMID: 29928978

    Sample: Plasma
  26. Scientific reports (2017) IF: 4.259
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    DOI: 10.1038/s41598-017-17566-w

    PMID: 29222448

    Sample: Serum
  27. Oxidative Medicine and Cellular Longevity (2017) IF: 4.593
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    DOI: 10.1155/2017/3869561

    PMID: 29081886

    Sample: Cell culture supernatant
  28. International Journal of Nanomedicine (2017) IF: 4.3
    Multifunctional Folate Receptor-targeting And pH-responsive Nanocarriers Loaded With Methotrexate For Treatment Of Rheumatoid Arthritis.

    DOI: 10.2147/IJN.S140992

    PMID: 28932117

    Sample: Serum
  29. Scientific Reports (2017) IF: 4.259
    Hydrogen Sulfide Ameliorates Chronic Renal Failure In Rats By Inhibiting Apoptosis And Inflammation Through ROS/MAPK And NF-κB Signaling Pathways.

    DOI: 10.1038/s41598-017-00557-2

    PMID: 28352125

    Sample: Tissue homogenate
  30. Oxidative Medicine & Cellular Longevity (2015) IF: 4.593
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    DOI: 10.1155/2015/965961

    PMID: 26301045

    Sample: Serum
  31. International Immunopharmacology (2020) IF: 3.943
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    DOI: 10.1016/j.intimp.2020.106771

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    Sample: Serum
  32. Immunology letters (2020) IF: 3.276
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    DOI: 10.1016/j.imlet.2020.06.010

    PMID: 32565114

    Sample: Serum
  33. European Journal of Pharmacology (2020) IF: 3.263
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    DOI: 10.1016/j.yexcr.2020.112086

    PMID: 32416091

    Sample: Serum,Cell sample
  34. Environmental Toxicology and Pharmacology (2020) IF: 3.292
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    DOI: 10.1016/j.etap.2020.103506

    PMID: 33002592

    Sample: Serum
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    DOI: 10.1016/j.etap.2020.103456

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    Sample: Serum,Tissue homogenate
  36. Experimental Biology and Medicine (2020) IF: 3.139
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    DOI: 10.1177/1535370220961038

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    Sample: Plasma
  37. European review for medical and pharmacological sciences (2020) IF: 3.024
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    DOI: 10.26355/eurrev_202006_21528

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    Sample: Serum
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    Sample: Serum
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    DOI: 10.1080/15384101.2020.1814025

    PMID: 32897801

    Sample: Cell culture supernatant
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    DOI: 10.1155/2020/8641026

    PMID: 32104151

    Sample: Soil,Water,Oil,Plant?Tissue,Plant?Fluid,Antibody,F
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    DOI: 10.1016/j.intimp.2020.106582

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    Sample: Plasma
  42. Obesity (2020) IF: 3.742
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    DOI: 10.1002/oby.22666

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    Sample: Cell culture supernatant
  43. Inflammation (2020) IF: 3.212
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    DOI: 10.1007/s10753-019-01123-w

    PMID: 31705353

    Sample: Serum
  44. Journal of Biochemical and Molecular Toxicology (2020) IF: 3.606
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    DOI: 10.1002/jbt.22427

    PMID: 31777137

    Sample: Serum,Tissue homogenate
  45. International Immunopharmacology (2020) IF: 3.943
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    DOI: 10.1016/j.intimp.2020.106615

    PMID: 32447219

    Sample: Plasma
  46. International Immunopharmacology (2020) IF: 3.943
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    DOI: 10.1016/j.intimp.2019.105978

    PMID: 31767546

    Sample: Tissue homogenate
  47. Biology of Reproduction (2019) IF: 3.322
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    DOI: 10.1093/biolre/ioz133

    PMID: 31342065

    Sample: Tissue homogenate
  48. European Journal of Pharmacology (2019) IF: 3.263
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    DOI: 10.1016/j.ejphar.2019.172786

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    Sample: Serum
  49. Life Sciences (2019) IF: 3.647
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    DOI: 10.1016/j.lfs.2019.117045

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    Sample: Serum
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    DOI: 10.1016/j.neuroscience.2018.09.041

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    Sample: Serum
  51. Inflammopharmacology (2018) IF: 3.304
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    DOI: 10.1007/s10787-018-0522-9

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    Sample: Tissue homogenate
  52. International Journal of Neuropsychopharmacology (2018) IF: 3.981
    Emodin rescued hyperhomocysteinemia-induced dementia and Alzheimer's disease-like features in rats

    DOI: 10.1093/ijnp/pyy090

    PMID: 30407508

    Sample: Plasma,Tissue homogenate
  53. Frontiers in pharmacology (2018) IF: 3.831
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    DOI: 10.3389/fphar.2018.01432

    PMID: 30564127

    Sample: Serum,Cell culture supernatant
  54. Journal of cellular physiology (2019) IF: 3.923
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    DOI: 10.1002/jcp.28126

    PMID: 30644097

    Sample: Serum
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    DOI: 10.3390/molecules24020340

    PMID: 30669379

    Sample: Plasma,Tissue homogenate
  56. Journal of Trace Elements in Medicine and Biology (2019) IF: 3.755
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    DOI: 10.1016/j.jtemb.2019.01.014

    PMID: 30910212

    Sample: Tissue homogenate
  57. Ecotoxicology and environmental safety (2019) IF: 3.974
    Cold stress provokes lung injury in rats co-exposed to fine particulate matter and lipopolysaccharide

    DOI: 10.1016/j.ecoenv.2018.10.064

    PMID: 30384172

    Sample: Tissue homogenate
  58. Journal of Cellular Physiology (2019) IF: 3.923
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    DOI: 10.1002/jcp.28513

    PMID: 30953351

    Sample: Tissue homogenate
  59. Environmental Toxicology and Pharmacology (2020) IF: 3.292
    Chronic exposure of bisphenol A impairs carbohydrate and lipid metabolism by altering corresponding enzymatic and metabolic pathways

    DOI: 10.1016/j.etap.2020.103387

    PMID: 32339907

    Sample: Serum
  60. Inflammopharmacology (2018) IF: 3.304
    SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy

    DOI: 10.1007/s10787-018-0522-9

    PMID: 30094758

    Sample: Serum
  61. International Journal of Neuropsychopharmacology IF: 3.98
    Emodin rescued hyperhomocysteinemia-induced dementia and Alzheimer's disease-like features in rats

    DOI: 10.1093/ijnp/pyy090

    PMID: 30407508

    Sample: Serum, Tissue homogenate
  62. Toxins (2018) IF: 3.273
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    DOI: 10.3390/toxins10110449

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    Sample: Serum, Tissue homogenate
  63. Phytomedicine (2018) IF: 3.61
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    DOI: 10.1016/j.phymed.2018.05.017

    PMID: 30195870

    Sample: Tissue homogenate
  64. Biomedicine & Pharmacotherapy (2018) IF: 3.457
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    DOI: 10.1016/j.biopha.2018.07.081

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    Sample: Serum
  65. Acta Cirurgica Brasileira (2018) IF: 3.0895
    Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation.

    DOI: 10.1590/s0102-865020180030000006

    PMID: 29668774

  66. Molecular Immunology (2018) IF: 3.236
    The Protective Effect Of Dexmedetomidine On LPS-Induced Acute Lung Injury Through The HMGB1-Mediated TLR4/NF-κB And PI3K/Akt/mTOR Pathways.

    DOI: 10.1016/j.molimm.2017.12.008

    PMID: 29241031

    Sample: Bronchoalveolar Lavage Fluid,Serum,Tissue homogena
  67. Molecular Immunology (2017) IF: 3.236
    NLRC5 Promotes Cell Proliferation Via Regulating The NF-κB Signaling Pathway In Rheumatoid Arthritis.

    DOI: 10.1016/j.molimm.2017.08.024

    PMID: 28865311

    Sample: Tissue homogenate,Cell lysate,Serum
  68. Phytotherapy Research (2017) IF: 3.092
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    DOI: 10.1002/ptr.5775

    PMID: 28127805

    Sample: Cell culture supernatant
  69. Basic & Clinical Pharmacology & Toxicology (2016) IF: 3.176
    Small Molecule Inhibiting NF-κB Ameliorates Oxidative Stress And Suppresses Renal Inflammation In Early Stage Of Alloxan-Induced Diabetic Nephropathy In Rat.

    DOI: 10.1111/bcpt.12718

    PMID: 27888584

    Sample: Tissue homogenate
  70. Physiology & Behavior (2020) IF: 2.826
    Inhibition of the fatty acid amide hydrolase changes behaviors and brain catecholamines in a sex-specific manner in rats exposed to chronic unpredictable stress

    DOI: 10.1016/j.physbeh.2020.113174

    PMID: 32966816

    Sample: Tissue homogenate
  71. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy (2020) IF: 2.842
    Activation of Nrf2 Signaling by Apelin Attenuates Renal Ischemia Reperfusion Injury in Diabetic Rats

    DOI: 10.2147/DMSO.S246743

    PMID: 32606875

    Sample: Serum
  72. Molecular Medicine Reports (2020) IF: 2.1
    Pretreatment with the ALDH2 activator Alda-1 protects rat livers from ischemia/reperfusion injury by inducing autophagy

    DOI: 10.3892/mmr.2020.11312

    PMID: 32705206

    Sample: Serum
  73. Journal of the Science of Food and Agriculture (2020) IF: 2.614
    Tiliacora triandra extract and its major constituent attenuates diabetic kidney and testicular impairment by modulating redox imbalance and pro-inflammatory responses in rats

    DOI: 10.1002/jsfa.10779

    PMID: 32875596

    Sample: Tissue homogenate
  74. Immunological Investigations (2020) IF: 2.511
    Overexpression of lncRNA HULC Attenuates Myocardial Ischemia/reperfusion Injury in Rat Models and Apoptosis of Hypoxia/reoxygenation Cardiomyocytes via Targeting miR-377-5p through NLRP3/Caspase-1/IL-1β Signaling Pathway Inhibition

    DOI: 10.1080/08820139.2020.1791178

    PMID: 32674625

    Sample: Cell culture supernatant
  75. Fundamental & Clinical Pharmacology (2020) IF: 2.754
    Ameliorative effect of Ozagrel, a thromboxane A2 synthase inhibitor, in hyperhomocysteinemia-induced experimental vascular cognitive impairment and dementia

    DOI: 10.1111/fcp.12610

    PMID: 33020931

    Sample: Tissue homogenate
  76. Journal of Ovarian Research (2020) IF: 2.989
    The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats

    DOI: 10.1186/s13048-020-00650-7

    PMID: 32386521

    Sample: Serum
  77. Digestive Diseases and Sciences (2020) IF: 2.751
    Apocynin Attenuates Acute Kidney Injury and Inflammation in Rats with Acute Hypertriglyceridemic Pancreatitis

    DOI: 10.1007/s10620-019-05892-0

    PMID: 31617131

    Sample: Serum
  78. Pharmaceutical Biology (2020) IF: 2.971
    Protective effect of apigenin magnesium complex on H 2 O 2-induced oxidative stress and inflammatory responses in rat hepatic stellate cells

    DOI: 10.1080/13880209.2020.1772840

    PMID: 32544362

    Sample: Cell culture supernatant
  79. PloS one (2020) IF: 2.74
    Associations of inflammatory markers with impaired left ventricular diastolic and systolic function in collagen-induced arthritis

    DOI: 10.1371/journal.pone.0230657

    PMID: 32208438

    Sample: Serum
  80. Future Microbiology (2020) IF: 2.907
    The anti-inflammatory, anti-oxidant and protective effects of a probiotic mixture on organ toxicity in a rat model

    DOI: 10.2217/fmb-2020-0005

    PMID: 32250184

    Sample: Serum
  81. Naunyn-Schmiedeberg's archives of pharmacology (2020) IF: 2.05
    Protective effect of oleuropein on ketamine-induced cardiotoxicity in rats

    DOI: 10.1007/s00210-020-01870

    PMID: 99999999

    Sample: Serum
  82. Cancer chemotherapy and pharmacology (2020) IF: 2.967
    The gut microbiota attenuates muscle wasting by regulating energy metabolism in chemotherapy-induced malnutrition rats

    DOI: 10.1007/s00280-020-04060-w

    PMID: 32415349

    Sample: Serum,Tissue homogenate,Feces
  83. Experimental and Clinical Endocrinology & Diabetes (2019) IF: 2.058
    Hyperuricemia Inhibition Protects SD Rats Against Fructose-Induced Obesity Hypertension Via Modulation of Inflammation and Renin-Angiotensin System in Adipose Tissue

    DOI: 10.1055/a-1023-6710

    PMID: 31683330

    Sample: Serum
  84. Canadian journal of physiology and pharmacology (2018) IF: 2.21
    Histopathological and biochemical changes in the development of nonalcoholic fatty liver disease induced by high-sucrose diet at different times

    DOI: 10.1139/cjpp-2018-0353

    PMID: 30388378

    Sample: Serum
  85. Bioscience reports (2018) IF: 2.899
    Shenqi Fuzheng Injection impairs bile duct ligation-induced cholestatic liver injury in vivo

    DOI: 10.1042/BSR20180787

    PMID: 30610157

    Sample: Tissue homogenate
  86. Journal of Neuroimmunology (2019) IF: 2.655
    The role of UCH-L1, MMP-9, and GFAP as peripheral markers of different susceptibility to seizure development in a preclinical model of epilepsy

    DOI: 10.1016/j.jneuroim.2019.03.018

    PMID: 30952062

    Sample: Plasma
  87. American Journal of Reproductive Immunology (2019) IF: 2.745
    Nisin Reduces Uterine Inflammation in Rats by Modulating Concentrations of Pro- And Anti-Inflammatory Cytokines

    DOI: 10.1111/aji.13096

    PMID: 30681748

    Sample: Serum
  88. Bioscience reports (2018) IF: 2.899
    Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats

    DOI: 10.1042/BSR20180892

    PMID: 30232232

    Sample: Tissue homogenate
  89. Journal of cellular biochemistry (2019) IF: 2.959
    Exosomes derived from miR-146a-modified adipose- derived stem cells attenuate acute myocardial infarction- induced myocardial damage via downregulation of early growth response factor 1

    DOI: 10.1002/jcb.27731

    PMID: 30362610

    Sample: Serum,Cell culture supernatant
  90. Journal of cellular biochemistry (2019) IF: 2.959
    MAPKs and NF-κB-mediated acrylamide-induced neuropathy in rat striatum and human neuroblastoma cells SY5Y

    DOI: 10.1002/jcb.27671

    PMID: 30368882

    Sample: Tissue homogenate
  91. Autoimmunity (2019) IF: 2.648
    The changes in immune cell concentration during the progression of pre-diabetes to type 2 diabetes in a high-fat high-carbohydrate diet-induced pre-diabetic rat model

    DOI: 10.1080/08916934.2019.1575820

    PMID: 30776930

    Sample: Plasma
  92. Neurochemical research (2019) IF: 2.772
    Interleukin-1 Receptor Associated Kinase 1 Mediates the Maintenance of Neuropathic Pain after Chronic Constriction Injury in Rats

    DOI: 10.1007/s11064-019-02767-8

    PMID: 30859436

    Sample: Tissue homogenate
  93. ACS omega (2020) IF: 2.87
    Antiarthritic Potential of Comprehensively Standardized Extract of Alternanthera bettzickiana: In Vitro and In Vivo Studies

    DOI: 10.1021/acsomega.0c01670

    PMID: 32803042

    Sample: Serum
  94. Cardiovascular Therapeutics (2020) IF: 2.538
    Bredemolic Acid Improves Cardiovascular Function and Attenuates Endothelial Dysfunction in Diet-Induced Prediabetes: Effects on Selected Markers

    DOI: 10.1155/2020/1936406

    PMID: 32117470

    Sample: Plasma,Tissue homogenate
  95. Inflammation (2018) IF: 2.884
    Protective Effect of Apigenin on Acrylonitrile-Induced Inflammation and Apoptosis in Testicular Cells via the NF-κB Pathway in Rats.

    DOI: 10.1007/s10753-018-0791-x

    PMID: 29687413

    Sample: Plasma
  96. Environmental Toxicology and Pharmacology (2018) IF: 2.776
    Diabetes escalates knee osteoarthritis in rats: Evidence of adaptive mechanism.

    DOI: 10.1016/j.etap.2018.05.009

    PMID: 29803977

    Sample: Serum
  97. Neuroscience Letters (2018) IF: 2.159
    Rutin Attenuates Neurobehavioral Deficits, Oxidative Stress, Neuro-Inflammation and Apoptosis in Fluoride Treated Rats.

    DOI: 10.1016/j.neulet.2018.06.023

    PMID: 29908257

    Sample: Tissue homogenate
  98. Cardiovascular Toxicology (2018) IF: 2.712
    Catechin Attenuates Coronary Heart Disease In A Rat Model By Inhibiting Inflammation.

    DOI: 10.1007/s12012-018-9449-z

    PMID: 29464499

  99. Gene (2018) IF: 2.415
    MicroRNA-24 regulates vascular remodeling via inhibiting PDGF-BB pathway in diabetic rat model.

    DOI: 10.1016/j.gene.2018.03.056

    PMID: 29559348

  100. BMC Complementary and Alternative Medicine (2015) IF: 2.288
    Edible Bird’S Nest Attenuates High Fat Diet-Induced Oxidative Stress And Inflammation Via Regulation Of Hepatic Antioxidant And Inflammatory Genes.

    DOI: 10.1186/s12906-015-0843-9

    PMID: 26341858

    Sample: Serum
  101. Biochemical And Biophysical Research Communications (2017) IF: 2.466
    Umbilical Cord-Derived Mesenchymal Stem Cells Alleviated Inflammation And Inhibited Apoptosis In Interstitial Cystitis Via AKT/mTOR Signaling Pathway.

    DOI: 10.1016/j.bbrc.2017.11.072

    PMID: 29137981

    Sample: Tissue homogenate
  102. Biochemical And Biophysical Research Communications (2017) IF: 2.466
    Edaravone Attenuates Lipopolysaccharide-induced Acute Respiratory Distress Syndrome Associated Early Pulmonary Fibrosis Via Inhibition Of Oxidative Stress And Transforming Growth Factor-β1/Smad3 Signaling.

    DOI: 10.1016/j.bbrc.2017.10.165

    PMID: 29102631

    Sample: Serum
  103. Inflammation (2017) IF: 2.955
    MeCP2 Regulates PTCH1 Expression Through DNA Methylation In Rheumatoid Arthritis.

    DOI: 10.1007/s10753-017-0591-8

    PMID: 28573530

    Sample: Cell culture supernatant
  104. Biomedicine & Pharmacotherapy (2017) IF: 2.759
    Anti-Steatotic And Anti-Inflammatory Effects Of Hovenia Dulcis Thunb. Extracts In Chronic Alcohol-Fed Rats.

    DOI: 10.1016/j.biopha.2017.03.077

    PMID: 28380415

    Sample: Serum
  105. International Journal of Molecular Medicine (2017) IF: 2.341
    Sirt1 Exerts Neuroprotective Effects By Attenuating Cerebral Ischemia/Reperfusion-Induced Injury Via Targeting P53/Microrna-22.

    DOI: 10.3892/ijmm.2016.2806

    PMID: 27878231

    Sample: Tissue homogenate
  106. BMC Complementary and Alternative Medicine (2015) IF: 2.288
    Edible Bird’S Nest Attenuates High Fat Diet-Induced Oxidative Stress And Inflammation Via Regulation Of Hepatic Antioxidant And Inflammatory Genes.

    DOI: 10.1186/s12906-015-0843-9

    PMID: 26341858

    Sample: Serum
  107. Journal of Surgical Research (2013) IF: 2.187
    Dobutamine-Mediated Heme Oxygenase-1 Induction Via PI3K And p38 MAPK Inhibits High Mobility Group Box 1 Protein Release And Attenuates Rat Myocardial Ischemia/Reperfusion Injury In Vivo.

    DOI: 10.1016/j.jss.2013.02.051

    PMID: 23531454

    Sample: Tissue homogenate
  108. Journal of Ethnopharmacology (2017) IF: 2.981
    Renoprotective And Antioxidative Effects Of Methanolic Paederia Foetida Leaf Extract On Experimental Diabetic Nephropathy In Rats.

    DOI: 10.1016/j.jep.2017.01.035

    PMID: 28111217

    Sample: Serum,Tissue homogenate
  109. European Journal of Pharmacology (2016) IF: 2.896
    The Protective Role Of Neuregulin-1: A Potential Therapy For Sepsis-Induced Cardiomyopathy.

    DOI: 10.1016/j.ejphar.2016.06.042

    PMID: 27346832

    Sample: Serum
  110. Plos One (2015) IF: 2.806
    Transplantation Of Induced Pluripotent Stem Cells Alleviates Cerebral Inflammation And Neural Damage In Hemorrhagic Stroke.

    DOI: 10.1371/journal.pone.0129881

    PMID: 26086994

    Sample: Tissue homogenate
  111. Microbial Pathogenesis (2016) IF: 2.009
    Candida Glabrata Induced Infection Of Rat Tracheal Epithelial Cells Is Mediated By TLR-2 Induced Activation Of NF-κB.

    DOI: 10.1016/j.micpath.2015.10.009

    PMID: 26477714

    Sample: Cell lysate
  112. Journal of Ethnopharmacology (2016) IF: 2.981
    Venenum Bufonis Induces Rat Neuroinflammation By Activiating NF-κB Pathway And Attenuation Of BDNF.

    DOI: 10.1016/j.jep.2016.03.049

    PMID: 27013094

    Sample: Tissue homogenate
  113. Journal of Biomedical Science (2015) IF: 2.799
    High Fat Diet-Induced Inflammation And Oxidative Stress Are Attenuated By N-Acetylneuraminic Acid In Rats.

    DOI: 10.1186/s12929-015-0211-6

    PMID: 26498218

    Sample: Serum
  114. International Immunopharmacology (2015) IF: 2.956
    Anti-Inflammatory Effects And Pharmacokinetics Study Of Geniposide On Rats With Adjuvant Arthritis.

    DOI: 10.1016/j.intimp.2014.11.017

    PMID: 25434608

    Sample: Cell culture supernatant
  115. International Immunopharmacology (2014) IF: 2.956
    Effects And Mechanisms Of Geniposide On Rats With Adjuvant Arthritis.

    DOI: 10.1016/j.intimp.2014.02.021

    PMID: 24583144

    Sample: Cell lysate
  116. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research (2020) IF: 1.918
    Evaluation of 2 Rat Models for Sepsis Developed by Improved Cecal Ligation/Puncture or Feces Intraperitoneal-Injection

    DOI: 10.12659/MSM.919054

    PMID: 31992687

    Sample: Plasma
  117. Asian Journal of Surgery (2020) IF: 1.838
    Potent therapeutic effects of ruscogenin on gastric ulcer established by acetic acid

    DOI: 10.1016/j.asjsur.2019.07.001

    PMID: 31345657

    Sample: Tissue homogenate
  118. in vivo (2019) IF: 1.541
    Oral Administration of Chitosan Attenuates Bleomycin-induced Pulmonary Fibrosis in Rats

    DOI: 10.21873/invivo.11624

    PMID: 31471392

    Sample: Bronchoalveolar Lavage Fluid
  119. Molecular Biology Reports (2019) IF: 1.402
    Protective effects of Anthocleista djalonensis A. Chev root extracts against induced testicular inflammation and impaired spermatogenesis in adult rats

    DOI: 10.1007/s11033-019-05033-w

    PMID: 31428909

    Sample: Serum,Tissue homogenate
  120. Annals of Surgical Treatment and Research (2019) IF: 1.367
    Examination of Protective and Therapeutic Effects of Ruscogenin on Cerulein-Induced Experimental Acute Pancreatitis in Rats

    DOI: 10.4174/astr.2019.97.6.271

    PMID: 31824881

    Sample: Serum,Tissue homogenate
  121. Biological and Pharmaceutical Bulletin (2018) IF: 1.54
    Qiliqiangxin Protects against Renal Injury in Rat with Cardiorenal Syndrome Type I through Regulating the Inflammatory and Oxidative Stress Signaling

    DOI: 10.1248/bpb.b17-00930

    PMID: 30068867

    Sample: Plasma
  122. Experimental and therapeutic medicine (2018) IF: 1.41
    Protective effect of dexpanthenol against cisplatin-induced hepatotoxicity

    DOI: 10.3892/etm.2018.6683

    PMID: 30402149

    Sample: Tissue homogenate
  123. Biotechnology & Biotechnological Equipment (2018) IF: 1.227
    Effect of polysaccharides from Vitis vinifera L. on NF-κB/IκB-α signal pathway and inflammatory factors in Alzheimer's model rats.

    DOI: 10.1080/13102818.2018.1464948

    Sample: Serum
  124. Experimental and Therapeutic Medicine (2018) IF: 1.41
    Bletilla striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAAinduced cirrhotic rats.

    DOI: 10.3892/etm.2018.6430

    PMID: 30186392

    Sample: Serum,Tissue homogenate
  125. Iranian Journal of Basic Medical Sciences (2018) IF: 1.424
    The Protective Effects Of Naringin Against 5-Fluorouracil-Induced Hepatotoxicity And Nephrotoxicity In Rats.

    DOI: 10.22038/IJBMS.2018.27510.6714

    PMID: 29796225

  126. Molecular Medicine Reports (2014) IF: 1.692
    IsoproterenolMediated Heme Oxygenase1 Induction Inhibits High Mobility Group Box 1 Protein Release And Protects Against Rat Myocardial Ischemia/Reperfusion Injury In Vivo.

    DOI: 10.3892/mmr.2014.2026

    PMID: 24604346

    Sample: Tissue homogenate
  127. Experimental and Therapeutic Medicine (2017) IF: 1.261
    Astragalus Polysaccharides Combined With Ibuprofen Exhibit A Therapeutic Effect On Septic Rats Via An Anti-Inflammatory Cholinergic Pathway.

    DOI: 10.3892/etm.2017.4865

    PMID: 28912862

    Sample: Plasma
  128. Experimental and Therapeutic Medicine (2018) IF: 1.261
    Gambogic Acid Exerts Cardioprotective Effects In A Rat Model Of Acute Myocardial Infarction Through Inhibition Of Inflammation, iNOS And NFκB/p38 Pathway.

    DOI: 10.3892/etm.2017.5599

    PMID: 29434760

    Sample: Serum
  129. Experimental and Therapeutic Medicine (2017) IF: 1.261
    Tocotrienol Alleviates Inflammation And Oxidative Stress In A Rat Model Of Spinal Cord Injury Via Suppression Of Transforming Growth Factor-β.

    DOI: 10.3892/etm.2017.4505

    PMID: 28672950

    Sample: Serum
  130. Medical Science Monitor (2017) IF: 1.585
    Epigallocatechin Gallate Attenuates Hip Fracture-Induced Acute Lung Injury By Limiting Mitochondrial Dna (Mtdna) Release.

    DOI: 10.12659/MSM.902477

    PMID: 28698540

    Sample: Bronchoalveolar Lavage Fluid
  131. Toxicology Research (2017) IF: 1.969
    Nano NIO Induced Liver Toxicity Via Activating The NF-κB Signaling Pathway In Rats.

    DOI: 10.1039/c6tx00444j

    PMID: 30090495

    Sample: Tissue homogenate
  132. Brazilian Journal of Medical and Biological Research (2017) IF: 1.578
    Angiotensin-(1-7) Relieved Renal Injury Induced By Chronic Intermittent Hypoxia In Rats By Reducing Inflammation, Oxidative Stress And Fibrosis.

    DOI: 10.1590/1414-431X20165594

    PMID: 28076452

    Sample: Plasma
  133. Molecular Medicine Reports (2015) IF: 1.692
    Asiaticoside Attenuates The Effects Of Spinal Cord Injury Through Antioxidant And AntiInflammatory Effects, And Inhibition Of The p38MAPK Mechanism.

    DOI: 10.3892/mmr.2015.4425

    PMID: 26458544

    Sample: Serum
  134. Immunopharmacology & Immunotoxicology (2016) IF: 1.475
    Anti-Oxidant And Anti-Inflammatory Effects Of Apigenin In A Rat Model Of Sepsis: An Immunological, Biochemical, And Histopathological Study.

    DOI: 10.3109/08923973.2016.1173058

    PMID: 27144896

    Sample: Serum
  135. Journal of Inflammation Research (2020)
    Pharmacological Inhibition of Galectin-3 Ameliorates Diabetes-Associated Cognitive Impairment, Oxidative Stress and Neuroinflammation in vivo and in vitro

    DOI: 10.2147/JIR.S273858

    PMID: 32982368

    Sample: Cell culture supernatant,Tissue homogenate
  136. Naunyn-Schmiedeberg's archives of pharmacology (2020)
    Protective effect of oleuropein on ketamine-induced cardiotoxicity in rats

    DOI: 10.1007/s00210-020-01870-w

    PMID: 32383030

    Sample: Tissue homogenate
  137. Journal of Family and Reproductive Health (2020)
    Protective effect of exogenous hydrogen sulfide on diaphragm muscle fibrosis in streptozotocin-induced diabetic rats

    DOI: 10.1177/1535370220931038

    PMID: 32493122

    Sample: Tissue homogenate
  138. Advances in Traditional Medicine (2020)
    Anti-inflammatory activity of Xanthium indicum on carrageenan-induced paw edema in rats

    DOI: 10.1007/s13596-020-00502-1

    PMID: 99999999

    Sample: Tissue homogenate
  139. Medicinal Plant (2017)
    Protection of Dicliptera chinensis Polysaccharide Granule on Acute Liver Injury of Rat Caused by D-galactosamine

    DOI: 99999999

    PMID: 99999999

    Sample: Serum,Tissue Slice
  140. Asian Journal of Research in Biochemistry (2019)
    Effect of Oral Intake of Sodium Benzoate on Serum Cholesterol and Proinflammatory Cytokine (Tumor Necrosis Factor Alpha [TNF-α] and Interleukin-6 [IL-6]) Levels in the Heart Tissue of Wistar Rats

    DOI: 10.9734/ajrb/2019/v5i230086

    PMID: 99999999

    Sample: Serum,Tissue homogenate
  141. Biomedical and Pharmacology Journal (2019)
    Therapeutic Intervention of Curcumin on Interleukin-6 and Oxidative Stress Induced by Paraquat Toxicity of Lung and Liver in Rats

    DOI: 10.13005/bpj/1803

    PMID: 99999999

    Sample: Serum
  142. New Trends in Medicine Sciences (2020)
    Role of 6-Shogaol Against Ovarian Torsion Detorsion-Induced Reproductive Organ Damage

    DOI: 99999999

    PMID: 99999999

    Sample: Tissue homogenate
  143. The Egyptian Journal of Forensic Sciences and Applied Toxicology (2020)
    ANTI-INFLAMMATORY AND ANTIOXIDANT PROPERTIES OF ECBALLIUM ELATERIUM FRUIT JUICE AGAINST CYCLOPHPSPHAMIDE INDUCED HEPATOTOXICITY IN RATS

    DOI: 99999999

    PMID: 99999999

    Sample: Plasma
  144. GSC Biological and Pharmaceutical Sciences (2019)
    Protective effects of naringin in indomethacin-induced gastric ulcer in rats

    DOI: 10.30574/gscbps.2019.8.2.0132

    PMID: 99999999

    Sample: Tissue homogenate
  145. Journal of Experimental Pharmacology (2020)
    Alpha-Mangostin Improves Cardiac Hypertrophy and Fibrosis and Associated Biochemical Parameters in High-Fat/High-Glucose Diet and Low-Dose Streptozotocin Injection-Induced Type 2 Diabetic Rats

    DOI: 10.2147/JEP.S233111

    PMID: 32095085

    Sample: Tissue homogenate
  146. International Journal of Clinical and Experimental Pathology (2020) IF: 0.252
    Sepsis causes heart injury through endoplasmic reticulum stress-mediated apoptosis signaling pathway

    DOI: 99999999

    PMID: 32509067

    Sample: Serum
  147. Borneo Journal of Pharmacy (2020)
    Level of Cytokine Interleukin-6 and Interleukin 1-β on Infectious Rat Model Treated with Etlingera elatior (Jack) RM Smith Fruit Extract as Immunomodulator

    DOI: 10.33084/bjop.v3i2.1318

    PMID: 99999999

    Sample: Plasma
  148. WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2018)
    SERUM INTERLEUKIN-6 AND GASTRIC MUCOSA EXPRESSION OF CD3 AND CD20 IN DYSTHYROID RATS

    DOI: 10.20959/wjpps20184-11252

    PMID: 99999999

    Sample: Serum,Tissue homogenate
  149. Pathology-Research and Practice (2018)
    miR-93-3p alleviates lipopolysaccharide-induced inflammation and apoptosis in H9c2 cardiomyocytes by inhibiting toll-like receptor 4

    DOI: 10.1016/j.prp.2018.08.024

    PMID: 30195636

    Sample: Cell culture supernatant
  150. Mustansiriya Medical Journal (2018)
    Evaluation of the effects of TAK-242 and GIT-27 on methotrexate-induced liver injury

    DOI: 10.4103/MJ.MJ_15_18

    PMID: 99999999

    Sample: Serum
  151. Synergy (2019)
    Effects of salmon calcitonin and omega-3fatty acids on selected biomarkers in experimental diabetic - osteoarthritic rats

    DOI: 10.1016/j.synres.2018.100045

    PMID: 99999999

    Sample: Plasma,Serum
  152. North-West University (2018)
    Studies on Garcinia mangostana Linn as a therapeutic intervention in an immune-inflammatory model of schizophrenia

    DOI: 99999999

    PMID: 99999999

    Sample: Plasma
  153. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy (2019)
    Cardioprotective effects of a ruthenium (II) Schiff base complex in diet-induced prediabetic rats.

    DOI: 10.2147/DMSO.S183811

    PMID: 30858714

    Sample: Tissue homogenate,Plasma
  154. Indonesian Journal of Tropical and Infectious Disease (2019)
    EFFECT OF AFRICAN LEAF (VERNONIA AMYGDALINA) TO IL-6 AND IL-10 LEVEL ON STAPHYLOCOCCUC AUREUS INFECTION

    DOI: 10.20473/ijtid.v7i4.9654

    PMID: 99999999

    Sample: Whole Blood
  155. Pathophysiology (2019)
    Pathophysiology of iron overload-induced renal injury and dysfunction: Roles of renal oxidative stress and systemic inflammatory mediators

    DOI: 10.1016/j.pathophys.2019.03.002

    PMID: 30910397

    Sample: Serum
  156. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE (2019) IF: 0.166
    Effects of methylene blue on the nitric oxide-soluble guanylate cyclase-cyclic guanylyl monophosphate pathway and cytokine levels in rats with sepsis

    DOI: 99999999

    PMID: 99999999

    Sample: Serum,Tissue homogenate
  157. Acta cirurgica brasileira (2018) IF: 0.993
    Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation.

    DOI: 10.1590/s0102-865020180030000006

    PMID: 29668774

    Sample: Serum
  158. bioRxiv (2018) IF: /
    Autophagy Decreases Alveolar Epithelial Cell Injury by Suppressing the NF-κB Signaling Pathway and Regulating the Release of Inflammatory Mediators.

    DOI: 10.1101/328039

    Sample: Tissue homogenate
  159. Acta Cirurgica Brasileira (2016) IF: 0.729
    Toll-Like Receptor 7 Involves The Injury In Acute Kidney Ischemia/Reperfusion Of STZ-Induced Diabetic Rats.

    DOI: 10.1590/S0102-865020160070000004

    PMID: 27487279

    Sample: Serum
  160. Renal Failure (2016) IF: 0.79
    Effect Of Apelin Hormone On Renal Ischemia/Reperfusion Induced Oxidative Damage In Rats.

    DOI: 10.1080/0886022X.2016.1184957

    PMID: 27197832

    Sample: Serum
  161. Iranian Journal of Immunology (2016) IF: 0.85
    The Immunostimulatory Effect Of Lactic Acid Bacteria In A Rat Model.

    DOI: IJIv13i3A7

    PMID: 27671513

    Sample: Serum
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