RBFOX3 Polyclonal Antibody

Uniprot : A6NFN3
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-12595

      Synonyms:FLJ56884,FLJ58356,Fox-1 homolog C,fox1 homolog C,Fox3,FOX3NeuN,hexaribonucleotide binding protein 3,HRNBP3,NEUN,neuronal nuclei,Rbfox3,RFOX3,RNA binding protein fox-1 homolog 3,RNA binding protein,fox 1 homolog (C. elegans) 3

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: WB,IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms FLJ56884,FLJ58356,Fox-1 homolog C,fox1 homolog C,Fox3,FOX3NeuN,hexaribonucleotide binding protein 3,HRNBP3,NEUN,neuronal nuclei,Rbfox3,RFOX3,RNA binding protein fox-1 homolog 3,RNA binding protein,fox 1 homolog (C. elegans) 3
      Swissprot A6NFN3
      Source Rabbit
      Reactivity Human ,Mouse
      Immunogen Synthetic peptide of human RBFOX3
      Application WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R217),ELISA
      Recommended dilution WB 1:200-1:1000 IHC 1:50-200
      Concentration 0.1 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus. Cytoplasm.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background Immunoprecipitation and mass spectrometry of the two major NeuN species at 45–50 kDa identified both as the RNA binding protein Rbfox3 (a member of the Fox family of alternative splicing factors), confirming and extending the identification of the 45 kDa band as Rbfox3. Mapping of the anti-NeuN reactive epitopes in both R3hdm2 and Rbfox3 reveals a common proline- and glutamine-rich domain that lies at the N-terminus of the Rbfox3 protein. Nuclear Rbfox3 isoforms can also enhance the inclusion of cryptic exons in the Rbfox2 mRNA, resulting in nonsense-mediated decay of the message, thereby contributing to the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism.

      Images

      polyclonal antibody-Elabscience

      Western Blot analysis of Jurkat cell using RBFOX3 Polyclonal Antibody at dilution of 1:550

      Immunohistochemistry of paraffin-embedded Human Brain using RBFOX3 Polyclonal Antibody at dilution of 1:100(Elabscience® Product Detected by Lifespan).

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