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Recombinant 2019-nCoV Helicase Protein (N-6His-MBP)

Uniprot : P0DTD1
  • Cat.No.:PKSR030466

  • Expression host: E.coli

To Purchase PKSR030466

  • 10µg
  • 50µg
Price: $220


Synonyms SARS-CoV 2 Helicase; SARS-CoV 2 nsp13
Species SARS-CoV-2
Expression_host E.coli
Sequence Ala5325-Gln5925
Accession P0DTD1
Mol_Mass 112.8 kDa
AP_Mol_Mass 120 kDa
Tag N-6His-MBP


Purity > 80 % as determined by reducing SDS-PAGE.
Endotoxin level Please contact us for more information.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
Formulation Supplied as a 0.2 μM filtered solution of PBS, pH 7.4.
Reconstitution Not Applicable


The non-structural protein 13 (nsp13) of 2019-nCoV is a helicase that separates double-stranded RNA or DNA with a 5'-3' polarity, using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 demonstrated that it can unwind both doublestranded DNA and RNA in a 5’-3’ direction, and it can hydrolyze all deoxyribonucleotide and ribonucleotide triphosphates. Helicases are motor proteins that utilize the energy derived from nucleotide hydrolysisto unwind double-stranded nucleic acids into two single-stranded nucleic acids. Initially, helicases were only thought to be molecular engines that unwind nucleic acids during replication, recombination, and DNA repair. Recent studies have shown that they are also involved in other biological processes, including displacement of proteins from nucleic acid, movement of Holliday junctions, chromatin remodeling, catalysis of nucleic acid conformational changes, several aspects of RNA metabolism, including transcription, mRNA splicing, mRNA export, translation, RNA stability and mitochondrial gene expression. Some human diseases, including Bloom’s syndrome, Werner’s syndrome, and Xeroderma Pigmentosum have been associated with defects in helicase function.


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