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Recombinant 2019-nCoV NSP1 Protein (His Tag)

Uniprot : YP_009725297.1
  • Cat.No.:PKSR030467

  • Expression host: E.coli

To Purchase PKSR030467

Size:
  • 10µg
  • 50µg
Price: $220
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Description

Synonyms SARS-CoV 2 nsp1; SARS-CoV 2 Leader protein
Species Virus
Expression_host E.coli
Sequence Met1-Gly180
Accession YP_009725297.1
Mol_Mass 22.7 kDa
AP_Mol_Mass 25 kDa
Tag C-6His

Properties

Purity > 85 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
Formulation Supplied as a 0.2 μM filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.5.
Reconstitution Please refer to the printed manual for detailed information.

Background

The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close association with cellular membranes. Nsp1 was proved to be able to suppress host gene expression by promoting host mRNA degradation and was involved in cellular chemokine deregulation. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling. Thus, nsp1 is a promising target for drugs, as inhibition of nsp1 would make SARS-CoV more susceptible to the host antiviral defenses.

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