Recombinant 2019-nCoV NSP1 Protein (His Tag)

    • Recombinant 2019-nCoV NSP1 Protein (His Tag)-Elabscience
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    • Recombinant 2019-nCoV NSP1 Protein (His Tag)-Elabscience
    • Recombinant 2019-nCoV NSP1 Protein (His Tag)-Elabscience

      Catalog number:PKSR030467

      Synonyms:SARS-CoV 2 nsp1; SARS-CoV 2 Leader protein

      Size:
      • 10µg
      • 50µg
      Qty:
      - +
      Price: $220

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms SARS-CoV 2 nsp1; SARS-CoV 2 Leader protein
      Species Virus
      Expression_host E.coli
      Sequence Met1-Gly180
      Accession YP_009725297.1
      Mol_Mass 22.7 kDa
      AP_Mol_Mass 25 kDa
      Tag C-6His

      Properties

      Purity > 85 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
      Formulation Supplied as a 0.2 μM filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.5.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close association with cellular membranes. Nsp1 was proved to be able to suppress host gene expression by promoting host mRNA degradation and was involved in cellular chemokine deregulation. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling. Thus, nsp1 is a promising target for drugs, as inhibition of nsp1 would make SARS-CoV more susceptible to the host antiviral defenses.
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      MSDS for ELISA ISO 9001

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