Recombinant 2019-nCoV Papain-Like Protease Protein (Active)

    • Recombinant Rat KLK10 Protein (His Tag)-Elabscience
    • Recombinant 2019-nCoV Papain-Like Protease Protein -Elabscience
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    • Recombinant Rat KLK10 Protein (His Tag)-Elabscience
    • Recombinant 2019-nCoV Papain-Like Protease Protein -Elabscience
    • Recombinant Rat KLK10 Protein (His Tag)-Elabscience
    • Recombinant 2019-nCoV Papain-Like Protease Protein -Elabscience

      Catalog number:PKSR030472

      Synonyms:Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a

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      • 10µg
      • 50µg
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      Price: $220

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      Overview

      Synonyms Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a
      Species Virus
      Expression_host E.coli
      Sequence Glu1564-Lys1878
      Accession QHD43415.1
      Mol_Mass 35.8 kDa
      AP_Mol_Mass 34 kDa
      Bio_Activity Measured by its ability to cleave a fluorogenic peptide substrate, (E-EDANS)RELNGGAPI(K-DABCYL)S (Synthetic).The specific activity is >2000pmoi/min/mg.

      Properties

      Purity > 90 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
      Formulation Supplied as a 0.2 μM filtered solution of 20mM Tris-HCl, 10 mM Mercaptoethanol [BME], 20% Glycerol, pH 7.5.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits; specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons.

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