Recombinant Actinin-α1 Monoclonal Antibody (AN301292L)
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For research use only.
| Verified Samples | Verified Samples in IHC: Human breast |
| Dilution | IHC 1:200-1:1000, WB 1:2000-1:10000, IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200, |
| Isotype | IgG,κ |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant Human Actinin-α1 protein |
| Abbre | Actinin-α1 |
| Synonyms | ACTN, Non-muscle alpha-actinin, BDPLT, ACTN1, BDPLT15, Alpha-actinin cytoskeletal isoform, F-actin cross-linking protein, Non-muscle alpha-actinin-1, actinin, actinin 1 smooth muscle, Actinin alpha 1, ACTN 1, alpha 1, Alpha Actinin 1, Alpha actinin cytoskeletal isoform, Alpha-actinin-1, F actin cross linking protein, FLJ40884, FLJ54432, Non muscle alpha actinin 1, Actinin-α1 |
| Swissprot | |
| Cellular Localization | Cytoplasm, cytoskeleton, Cytoplasm, myofibril, sarcomere, Z line, Cell membrane, Cell junction, Cell projection, ruffle, Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures. |
| Concentration | 0.2 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A |
| Research Areas | Signal Transduction, Stem Cells, Developmental Biology |
| Clone | B1055 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. |
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