Recombinant Clusterin/Apolipoprotein J/Apo-J Monoclonal Antibody (AN300045P)

Name: Recombinant Clusterin/Apolipoprotein J/Apo-J Monoclonal Antibody
Brand: Elabscience
SKU: AN300045P
Price: 380.0 USD
Availability: InStock

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Recombinant Clusterin/Apolipoprotein J/Apo-J Monoclonal Antibody - 1

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Verified Samples	Verified Samples in WB:Human fetal lung
Dilution	WB: 1:1000；IHC-P: 1:100-1:500
Isotype	IgG
Host	Rabbit
Reactivity	Human
Applications	WB, IHC-P
Clonality	Recombinant;Monoclonal
Immunogen	Recombinant Human Clusterin / Apolipoprotein J / Apo-J protein
Abbre	CLU
Synonyms	KUB, AAG, Ku70-binding protein, Sulfated glycoprotein, Complement-associated protein SP, Testosterone-repressed prostate message, NA1/NA, SGP, CLU, AAG4, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, clusterin, CLUS, Aging-associated gene 4 protein, Apolipoprotein J, Complement cytolysis inhibitor, Complement-associated protein SP-40, Ku70-binding protein 1, Sulfated glycoprotein2, Testosterone-repressed prostate message 2, Complement cytolysis inhibitor a chain, Clusterin alpha chain, Complement cytolysis inhibitor b chain, APOJ CLI, Sulfated glycoprotein 2
Swissprot	P10909
Calculated MW	53 kDa
Observed MW	35,65 kDa The actual band is not consistent with the expectation. Western blotting is a method for detecting a certain protein in a complex sample based on the specific binding of antigen and antibody. Different proteins can be divided into bands based on different mobility rates. The mobility is affected by many factors, which may cause the observed band size to be inconsistent with the expected size. The common factors include: 1. Post-translational modifications: For example, modifications such as glycosylation, phosphorylation, methylation, and acetylation will increase the molecular weight of the protein. 2. Splicing variants: Different expression patterns of various mRNA splicing bodies may produce proteins of different sizes. 3. Post-translational cleavage: Many proteins are first synthesized into precursor proteins and then cleaved to form active forms, such as COL1A1. 4. Relative charge: the composition of amino acids (the proportion of charged amino acids and uncharged amino acids). 5. Formation of multimers: For example, in protein dimer, strong interactions between proteins can cause the bands to be larger. However, the use of reducing conditions can usually avoid the formation of multimers. If a protein in a sample has different modified forms at the same time, multiple bands may be detected on the membrane.
Cellular Localization	Nucleus, Cytoplasm, Mitochondrion membrane, Peripheral membrane protein, Cytoplasm, Microsome, Endoplasmic reticulum, Mitochondrion
Tissue Specificity	Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in brain, testis, ovary, liver and pancreas, lower levels in kidney, heart, spleen and lung.
Concentration	1 mg/mL
Buffer	0.2 μm filtered solution in PBS
Purification Method	Protein A
Research Areas	Immunology, Cardiovascular, Signal Transduction, Cancer, Metabolism
Clone	A1155
Conjugation	Unconjugated
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping	Ice bag
background	The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]