Recombinant Cynomolgus CRTAM/CD355 Protein (Fc Tag)

    • Recombinant Cynomolgus CRTAM / CD355 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Cynomolgus CRTAM / CD355 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Cynomolgus CRTAM / CD355 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSQ050012

      Synonyms:Cytotoxic and Regulatory T-Cell Molecule; Class-I MHC-Restricted T-Cell-Associated Molecule; CD355; CRTAM

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $129

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      Overview

      Synonyms Cytotoxic and Regulatory T-Cell Molecule; Class-I MHC-Restricted T-Cell-Associated Molecule; CD355; CRTAM
      Species Cynomolgus
      Expression_host Human Cells
      Sequence Ser18-Gly287
      Accession A0A2K5TKL4
      Mol_Mass 57.1 kDa
      AP_Mol_Mass 80-90 kDa
      Tag C-Fc

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.5.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Cytotoxic and Regulatory T-Cell Molecule (CRTAM) is a member of Nectin family under the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and it is highly expressed by Purkinje cells of the cerebellum. CRTAM is a type I transmembrane glycoprotein containing one Ig-like C2-type domain and one Ig-like V-type domain in its extracellular domain, while its cytoplasmic region shows a potential class I PDZ domain. CRTAM is expressed as a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor coengagement of CD8+ cells expressiong CRTAM induces increased IFNγ or IL-22 production.

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