Recombinant Cynomolgus CSF1R/CD115 Protein (Fc Tag)

    • Recombinant Cynomolgus CSF1R  /  MCSF Receptor  /  CD115 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Cynomolgus CSF1R  /  MCSF Receptor  /  CD115 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Cynomolgus CSF1R  /  MCSF Receptor  /  CD115 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSQ050033

      Synonyms:Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD115; CSF1R; FMS;MCSF Receptor

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $111

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD115; CSF1R; FMS;MCSF Receptor
      Species Cynomolgus
      Expression_host Human Cells
      Sequence Ile20-Pro517
      Accession XP_005558297
      Mol_Mass 82.2 kDa
      AP_Mol_Mass 105-130 kDa
      Tag C-Fc

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.5.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. CSF1R is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. It plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. It is required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases.

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