Recombinant Cynomolgus Interleukin-4 Receptor Subunit Alpha/IL-4 Rα Protein (His Tag)

    • Recombinant Cynomolgus Interleukin-4 Receptor Subunit Alpha/IL-4 Rα Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Cynomolgus Interleukin-4 Receptor Subunit Alpha/IL-4 Rα Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Cynomolgus Interleukin-4 Receptor Subunit Alpha/IL-4 Rα Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSQ050053

      Synonyms:Interleukin-4 receptor subunit alpha;IL-4R-alpha;CD124;IL4-BP;Soluble IL-4R-alpha

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $129

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Interleukin-4 receptor subunit alpha;IL-4R-alpha;CD124;IL4-BP;Soluble IL-4R-alpha
      Species Cynomolgus
      Expression_host Human Cells
      Sequence Met26-Arg232
      Accession G7Q0S7
      Application Functional ELISA
      Mol_Mass 24.6 kDa
      AP_Mol_Mass 40 kDa
      Tag C-His
      Bio_Activity Immobilized Human IL-4(Cat: PKSH033456) at 10μg/ml(100 μl/well) can bind Human IL-4Ra-His. The ED50 of Human IL-4Ra-His is 7μg/mL.

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin receptor substrates, IRS1/IRS2. The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gamma chain. In immune cells, IL-4RA creates a type I receptor. In non-immune cells, it forms a type II receptor with of IL13RA1. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP.

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      MSDS for ELISA ISO 9001

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