Recombinant Cynomolgus PD-1/CD279/PDCD1 Protein (Fc Tag)

    • Recombinant Protein-Elabscience
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    • Recombinant Protein-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSQ050027

      Synonyms:Programmed cell death 1; PD-1; PD1; Programmed cell death protein 1

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $117

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      Overview

      Synonyms Programmed cell death 1; PD-1; PD1; Programmed cell death protein 1
      Species Cynomolgus
      Expression_host Human Cells
      Sequence Leu25-Gln167
      Accession B0LAJ3
      Mol_Mass 42.9 kDa
      AP_Mol_Mass 60-75 kDa
      Tag C-Fc

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
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      MSDS for ELISA ISO 9001

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