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Recombinant Cynomolgus PVRIG (C-6His)

Uniprot : A0A2K5WVV8
  • Cat.No.:PKSQ050123

  • Expression host: HEK293 Cells

To Purchase PKSQ050123

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  • 10μg
  • 50μg
Price: $132
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Description

Synonyms C7orf15;CD112R;PVRIG;transmembrane protein PVRIG;C7orf15MGC138295;MGC104322;MGC138297;MGC2463
Species Cynomolgus macaques
Expression_host HEK293 Cells
Sequence Thr41-Asp171
Accession A0A2K5WVV8
Mol_Mass 14.5 kDa
AP_Mol_Mass 20-30 kDa
Tag C-His

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.

Background

PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

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