Recombinant Human 14-3-3 epsilon/YWHAE Protein (PKSH031395)
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For research use only.
| Synonyms | 14-3-3E, HEL2, KCIP-1, MDCR, MDS |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Gln 255 |
| Accession | NP_006752.1 |
| Calculated Molecular Weight | 29.4 kDa |
| Observed Molecular Weight | 29.4 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
| Form | Lyophilized powder |
| Purity | > 96 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile 50 mM Tris, 150 mM NaCl, 0.1 mM DTT, 10% Glycerol, pH 7.5. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | YWHAE; also known as 14-3-3 epsilon; mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 epsilon / YWHAE is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism; protein trafficking; signal transduction; apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm; and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 epsilon / YWHAE is found in both plants and mammals; and this protein is 100% identical to the mouse ortholog. YWHAE interacts with CDC25 phosphatases; RAF1 and IRS1 proteins; suggesting its role in diverse biochemical activities related to signal transduction; such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 epsilon / YWHAE is implicated in the regulation of a large spectrum of both general and specialized signaling pathways. 14-3-3 epsilon / YWHAE Binds to a large number of partners; usually by recognition of a phosphoserine or phosphothreonine motif. This Binding generally results in the modulation of the activity of the binding partner. |
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