Recombinant Human ACE2 Protein (Fc Tag)

    • Recombinant Human ACE2 Protein (Fc Tag)-Elabscience
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    • Recombinant Human ACE2 Protein (Fc Tag)-Elabscience
    • Recombinant Human ACE2 Protein (Fc Tag)-Elabscience

      Catalog number:PKSR030492

      Synonyms:Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2

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      • 10µg
      • 50µg
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      Price: $156

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      Overview

      Synonyms Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
      Species Human
      Expression_host Human Cells
      Sequence Gln18-Ser740
      Accession Q9BYF1
      Mol_Mass 110.5 kDa
      AP_Mol_Mass 110-140 kDa
      Tag C-Fc
      Bio_Activity Immobilized Human ACE-2-Fc(Cat#PKSR030492) at 2μg/ml (100 μl/well) can bind 2019-nCoV S Protein RBD-SD1-mFc(Cat#PKSR030476). The ED50 of PKSR030476 is 15.5 ng/ml .

      Properties

      Purity > 95 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
      Formulation Supplied as a 0.2 μM filtered solution of 20mM Tris-HCl, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.

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