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Recombinant Human ACE2 Protein (His Tag)

Uniprot : Q9BYF1
  • Cat.No.:PKSH032068

  • Expression host: HEK293 Cells

To Purchase PKSH032068

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  • 10µg
  • 50µg
Price: $223
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Description

Synonyms Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
Species Human
Expression_host HEK293 Cells
Sequence Gln18-Ser740
Accession Q9BYF1
Mol_Mass 84.6 kDa
AP_Mol_Mass 103 kDa
Tag C-6His
Bio_Activity Testing in progress

Properties

Purity >95 % as determined by reducing SDS-PAGE.
Endotoxin level <1.0 EU per µg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4.
Reconstitution Not Applicable

Background

Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.

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