Synonyms	Aldo-Keto Reductase Family 1 Member C2;3-Alpha-HSD3;Chlordecone Reductase Homolog HAKRD;Dihydrodiol Dehydrogenase 2;DD-2;DD2;Dihydrodiol Dehydrogenase/Bile Acid-Binding Protein;DD/BABP;Trans-1;2-Dihydrobenzene-1;2-Diol Dehydrogenase;Type III 3-Alpha-Hydroxysteroid Dehydrogenase;AKR1C2;DDH2
Species	Human
Expression_host	E.coli
Sequence	Met 1-Tyr323
Accession	P52895
Mol_Mass	36.7 kDa
AP_Mol_Mass	35 kDa
Tag	None

Properties

Purity	> 90 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, pH 8.0.
Reconstitution	Not Applicable

Background

Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation of the most potent androgen 5-α-Dihydrotestosterone (5-α-DHT) to 5-α-Androstane-3-α, 17-β-diol (3-α-diol).

Citations

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