Recombinant Human ALDH7A1/ATQ1 Protein (His Tag) (PKSH031063)
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For research use only.
| Synonyms | ATQ1, EPD, PDE |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ser 2-Gln 511 |
| Accession | P49419-2 |
| Calculated Molecular Weight | 56.0 kDa |
| Observed Molecular Weight | 56 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
| Form | Liquid |
| Purity | > 93 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as sterile 50mM Tris, 500mM NaCl, 20% glycerol, pH 8.0 |
| Background | ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Mammalian ALDH7A1 is homologous to plant ALDH7B1 which protects against various forms of stress such as increased salinity, dehydration and treatment with oxidants or pesticides. In mammals, ALDH7A1 is known to play a primary role during lysine catabolism through the NAD+-dependent oxidative conversion of aminoadipate semialdehyde (AASA) to its corresponding carboxylic acid, α-aminoadipic acid. Deleterious mutations in human ALDH7A1 are responsible for pyridoxine-dependent and folinic acid-responsive seizures. ALDH7A1 is a novel aldehyde dehydrogenase expressed in multiple subcellular compartments that protects against hyperosmotic stress by generating osmolytes and metabolizing toxic aldehydes. |
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