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Recombinant Human APE1/APE Protein

Uniprot : P27695
  • Cat.No.:PKSH032090

  • Expression host: E.coli

To Purchase PKSH032090

Size:
  • 10μg
  • 50μg
Price: $275
Qty:

Description

Synonyms DNA-(Apurinic or Apyrimidinic Site) Lyase;APEX Nuclease;APEN;Apurinic-Apyrimidinic Endonuclease 1;AP Endonuclease 1;APE-1REF-1;Redox Factor-1;APEX1;APE;APE1;APEX;APX;HAP1;REF1
Species Human
Expression_host E.coli
Sequence Pro2-Leu318
Accession AAH02338.1
Mol_Mass 35.6 kDa
AP_Mol_Mass 40 kDa
Tag None

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 10mM HEPES, 100mM KCl, 50% Glycerol, pH 7.4.
Reconstitution Not Applicable

Background

Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases; APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors; which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors; such as c-Jun; c-Fos; NF-kB; p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.

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