Synonyms	Cysteine Protease ATG4A;AUT-Like 2 Cysteine Endopeptidase;Autophagin-2;Autophagy-Related Cysteine Endopeptidase 2;Autophagy-Related Protein 4 Homolog A;hAPG4A;ATG4A;APG4A;AUTL2
Species	Human
Expression_host	E.coli
Sequence	Met 1-Val398
Accession	Q8WYN0
Mol_Mass	47.5 kDa
AP_Mol_Mass	40-55 kDa
Tag	N-His

Properties

Purity	> 80 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution	Not Applicable

Background

Cysteine Protease ATG4A (ATG4A) is a cytoplasmic protein that belongs to the peptidase C54 family. ATG4A is widely expressed in many tissues at a low level, but the highest expression is observed in skeletal muscle and brain. ATG4A is a cysteine protease required for autophagy; it cleaves the C-terminal part of MAP1LC3, GABARAPL2 or GABARAP. ATG4A is inhibited by N-ethylmaleimide. It is suggested that ATG4A has a significant role in suppressing various cancers.

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