Recombinant Human BDNF Protein (with pro peptide)(Active)

    • Recombinant Human BDNF Protein (with pro peptide)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human BDNF Protein (with pro peptide)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human BDNF Protein (with pro peptide)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033559

      Synonyms:Brain-Derived Neurotrophic Factor; BDNF; Abrineurin

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $129

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Brain-Derived Neurotrophic Factor; BDNF; Abrineurin
      Species Human
      Expression_host E.coli
      Sequence Ala19-Arg247(R125A,R127A,R128A)
      Accession P23560
      Application Functional ELISA
      Mol_Mass 25.9 kDa
      AP_Mol_Mass 28 kDa
      Bio_Activity Immobilized Human pro-BDNF at 2ug/ml(100 μl/well) can bind Human TrkB-His(Cat: PKSH033579). The ED50 of Human pro-BDNF is 1.4 ug/ml .

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.

      Image

      Immobilized Human pro-BDNF at 2ug/ml(100 μl/well) can bind Human TrkB-His(Cat: PKSH033579). The ED50 of Human pro-BDNF is 1.4 ug/ml.

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