Recombinant Human β-NGF/NGFB Protein (with pro peptide)(Active)

    • Recombinant Human β-Nerve Growth Factor / β-NGF Protein (with pro peptide) -Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human β-Nerve Growth Factor / β-NGF Protein (with pro peptide) -Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human β-Nerve Growth Factor / β-NGF Protein (with pro peptide) -Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033552

      Synonyms:Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $129

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      Overview

      Synonyms Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB
      Species Human
      Expression_host E.coli
      Sequence Glu19-Ala241
      Accession P01138
      Application Cell Culture
      Mol_Mass 25 kDa
      AP_Mol_Mass 30 kDa
      Bio_Activity Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is 32697 pg/mL.

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystin knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration.

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