Recombinant Human BLNK/Ly-57 Protein (His Tag)

    • Recombinant Human BLNK / Ly-57 / SLP-65 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human BLNK / Ly-57 / SLP-65 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human BLNK / Ly-57 / SLP-65 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033753

      Synonyms:B-Cell Linker Protein; B-Cell Adapter Containing a SH2 Domain Protein; B-Cell Adapter Containing a Src Homology 2 Domain Protein; Cytoplasmic Adapter Protein; Src Homology 2 Domain-Containing Leukocyte Protein of 65 kDa; SLP-65; BLNK; BASH; SLP65

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $178

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      Overview

      Synonyms B-Cell Linker Protein; B-Cell Adapter Containing a SH2 Domain Protein; B-Cell Adapter Containing a Src Homology 2 Domain Protein; Cytoplasmic Adapter Protein; Src Homology 2 Domain-Containing Leukocyte Protein of 65 kDa; SLP-65; BLNK; BASH; SLP65
      Species Human
      Expression_host E.coli
      Sequence Met1-Ser456
      Accession Q8WV28
      Mol_Mass 51.5 kDa
      AP_Mol_Mass 40-80 kDa
      Tag C-His

      Properties

      Purity > 90% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 1mM DTT, pH 7.2.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      B-Cell Linker Protein (BLNK) is a cell membrane protein which contains 1 SH2 domain. BLNK is expressed in B cells and fibroblast cell lines, playing a important role in B cell receptor signaling. BLNK as a central linker protein, downstream of the B-cell receptor (BCR), bridges the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. BLNK associates with the activation of ERK/EPHB2, MAP kinase p38 and JNK, modulates AP1, NF-kappa-B and NFAT activation. BLNK involves in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. BLNK deficiency results in agammaglobulinemia type 4 and much more profound block in B-cell development.

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