Recombinant Human BLyS/TNFSF13B/BAFF Protein (Fc Tag)

    • Recombinant Human BLyS / TNFSF13B / BAFF Protein (N-Fc)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human BLyS / TNFSF13B / BAFF Protein (N-Fc)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human BLyS / TNFSF13B / BAFF Protein (N-Fc)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033499

      Synonyms:BAFF;BLYS;CD257;DTL;TALL-1;TALL1;THANK;TNFSF20;ZTNF4

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $129

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms BAFF;BLYS;CD257;DTL;TALL-1;TALL1;THANK;TNFSF20;ZTNF4
      Species Human
      Expression_host Human Cells
      Sequence Ala134-Leu285
      Accession Q9Y275
      Mol_Mass 43.3 kDa
      AP_Mol_Mass 54 kDa
      Tag N-Fc

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      TNFSF13B/TNFSF20 belongs to the tumor necrosis factor family. It abundantly is expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3 acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface. Isoform 3 is unlikely form trimers or bind to BAFF receptors. Mature human BAFF consists of a 46 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 218 aa extracellular domain (ECD) with a stalk region and one TNF-like domain. Within aa 134-285 of the ECD, human BAFF shares 72% aa sequence identity with mouse BAFF.

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