Recombinant Human BTN2A1 Protein (His Tag)

    • Recombinant Human BTN2A Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human BTN2A Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human BTN2A Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033746

      Synonyms:Butyrophilin subfamily 2 member A1; BTN2A1; BT2.1; BTF1

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $111

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      Overview

      Synonyms Butyrophilin subfamily 2 member A1; BTN2A1; BT2.1; BTF1
      Species Human
      Expression_host Human Cells
      Sequence Gln29-Ala248
      Accession Q7KYR7
      Mol_Mass 25.4 kDa
      AP_Mol_Mass 39-44 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Butyrophilin 2A1 (BTN2A1) is an approximately widely expressed and variably glycosylated type I transmembrane glycoprotein. Mature human Butyrophilin 2A1 consisits of a 220 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 258 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A1 that lack the first Ig like domain or transmembrane segment as well as isoforms with substitutions and deletions in the cytoplasmic region. BTN2A1 is widely expressed including on colonic epithelial cells, on immune cells, and in milk fat globules. It binds to the C-type lectin DCSIGN on monocytederived dendritic cells, and this interaction can be blocked by soluble gp130 from HIV. The polymorphism of BTN2A1 has been associated with metabolic syndrome, type II diabetes mellitus, chronic kidney disease, and hypertension.

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