Recombinant Human CAMK1 / CaMKI-alpha Protein

    • Recombinant Human CAMK1 / CaMKI-alpha Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human CAMK1 / CaMKI-alpha Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human CAMK1 / CaMKI-alpha Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030469

      Synonyms:CAMKI

      Size:
      • 20 µg
      • 50 µg
      Qty:
      - +
      Price: $454

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms CAMKI
      Species Human
      Expression_host E.coli
      Sequence Leu 2-Leu 370
      Accession NP_003647.1
      Mol_Mass 41.5 kDa
      AP_Mol_Mass 42 kDa

      Properties

      Purity > 85 % as determined by reducing SDS-PAGE.
      Endotoxin Please contact us for more information.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile 50mM Tirs, 150mM NaCl, 10% glycerol, pH 7.5
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Calcium/calmodulin-dependent protein kinase or CaM kinases are serine/threonine-specific protein kinases that are primarily regulated by the Calcium/calmodulin complex. These kinases show a memory effect on activation. CaM kinases activity can outlast the intracellular calcium transient that is needed to activate it. In neurons, this property is important for the induction of synaptic plasticity. Pharmacological inhibition of CaM kinases II blocks the induction of long-term potentiation. Upon activation, CaM kinases II phosphorylates postsynaptic glutamate receptors and changes the electrical properties of the synapse. Calcium/calmodulin-dependent protein kinase type 1D, also known as CaM kinase I delta, CaM kinase ID, CaMKI-like protein kinase, CKLiK and CAMK1D, is a member of the protein kinase superfamily and CaMK subfamily. It contains one protein kinase domain. CAMK1D is broadly expressed. It is highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. Engineered overexpression of CAMK1D in non-tumorigenic breast epithelial cells led to increased cell proliferation, and molecular and phenotypic alterations indicative of epithelial-mesenchymal transition (EMT), including loss of cell-cell adhesions and increased cell migration and invasion. CAMK1D is a potential therapeutic target with particular relevance to clinically unfavorable basal-like tumors.

      SDS-PAGE

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