Recombinant Human CD147/Basigin Protein (His Tag)

    • Recombinant Human CD147 / EMMPRIN / Basigin Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human CD147 / EMMPRIN / Basigin Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human CD147 / EMMPRIN / Basigin Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH031784

      Synonyms:Basigin; 5F7; Collagenase Stimulatory Factor; Extracellular Matrix Metalloproteinase Inducer; EMMPRIN; Leukocyte Activation Antigen M6; OK Blood Group Antigen; Tumor Cell-Derived Collagenase Stimulatory Factor; TCSF; CD147; BSG

      Size:
      • 50 μg
      • 100 μg
      Qty:
      - +
      Price: $486

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Basigin; 5F7; Collagenase Stimulatory Factor; Extracellular Matrix Metalloproteinase Inducer; EMMPRIN; Leukocyte Activation Antigen M6; OK Blood Group Antigen; Tumor Cell-Derived Collagenase Stimulatory Factor; TCSF; CD147; BSG
      Species Human
      Expression_host HEK293 Cells
      Sequence Met 1-His 205
      Accession NP_940991.1
      Mol_Mass 21.6 kDa
      AP_Mol_Mass 30-40 kDa
      Tag C-His

      Properties

      Purity > 97 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.

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