Synonyms	Poliovirus Receptor;Nectin-Like Protein 5;NECL-5;CD155;PVR;PVS
Species	Human
Expression_host	HEK293 Cells
Sequence	Trp21-Asn343
Accession	NP_006496
Application	Functional ELISA
Mol_Mass	36.1 kDa
AP_Mol_Mass	58 kDa
Tag	C-His
Bio_Activity	Loaded Human TIGIT-Fc on Protein A Biosensor, can bind Human PVR-His with an affinity constant of 4.22 nM as determined in BLI assay.

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution	Not Applicable

Background

Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV); an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains; a transmembrane segment; and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (α; β; γ; and δ) with identical extracellular domains.

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Citations

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