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Recombinant Human CD27/TNFRSF7 Protein (Fc Tag)(Active)

  • Cat.No.:PKSH031924

  • Expression host: HEK293 Cells

To Purchase PKSH031924

Size:
  • 100μg
  • 200μg
Price: $454
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Description

Synonyms S152;S152. LPFS2;S152.LPFS2;T14;TNFRSF7;Tp55
Species Human
Expression_host HEK293 Cells
Sequence Met 1-Ile192
Accession P26842
Application Functional ELISA
Mol_Mass 44.4 kDa
AP_Mol_Mass 63 kDa
Tag C-Fc
Bio_Activity Measured by its binding ability in a functional ELISA.Immobilized human CD27-his at 10 μg/mL (100 μl/well) can bind biotinylated human CD70-Fc, The EC50 of biotinylated human CD70-Fc is 95-150 ng/mL.

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Reconstitution Please refer to the printed manual for detailed information.

Background

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.

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