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Recombinant Human CDKN1B Protein (His Tag)

Uniprot : P46527
  • Cat.No.:PKSH032314

  • Expression host: E.coli

To Purchase PKSH032314

Size:
  • 10μg
  • 50μg
Price: $178
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Description

Synonyms Cyclin-Dependent Kinase Inhibitor 1B;Cyclin-Dependent Kinase Inhibitor p27;p27Kip1;CDKN1B;KIP1
Species Human
Expression_host E.coli
Sequence Met 1-Thr198
Accession P46527
Mol_Mass 24.2 kDa
AP_Mol_Mass 30 kDa
Tag N-His
Bio_Activity Not validated for activity

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.

Background

Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an activator of Cyclin Type D-CDK4 complexes depending on its phosphorylation state and stoichometry.

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