Synonyms	Complement Factor H-Related Protein 1;FHR-1;H Factor-Like Protein 1;H-Factor-Like 1;H36;CFHR1;CFHL;CFHL1;CFHL1P;CFHR1P;FHR1;HFL1;HFL2
Species	Human
Expression_host	HEK293 Cells
Sequence	Glu19-Arg330
Accession	Q03591
Mol_Mass	36.8 kDa
AP_Mol_Mass	37-52 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 8% Trehalose, 4% Mannitol, 50mM NaCl, 0.05% Tween 80, pH7.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the speci
Reconstitution	Please refer to the printed manual for detailed information.

Background

Complement Factor H-Related 1 (CFHR1) is a 43 kDa secreted member of the factor H family of glycoproteins. The human Complement Factor H protein family consists of the complement and immune regulators factor H; the factor H-like protein 1 (FHL-1) and five factor H-related proteins (CFHR-1 to -5). Members of the H-related protein family are exclusively composed of individually folded protein domains; termed short consensus repeats (SCRs) or complement control modules. FHR1 is produced by hepatocytes and circulates as two differentially glycosylated isoforms (37 kDa and 43 kDa). Mature human FHR1 is 312 amino acids in length. It contains five; approximately 60 aa SCRs that basically constitute the entire molecule. FHR1 may play a role in complement regulation; lipid metabolism and lipoprotein complexes that bind PMNs to LPS.

Citations

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