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Recombinant Human CNDP1 Protein (His Tag)

  • Cat.No.:PKSH033451

  • Expression host: HEK293 Cells
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Description

Synonyms Beta-Ala-His Dipeptidase;CNDP Dipeptidase 1;Carnosine Dipeptidase 1;Glutamate Carboxypeptidase-Like Protein 2;Serum Carnosinase;CNDP1;CN1;CPGL2;HsT2308
Species Human
Expression_host HEK293 Cells
Sequence Pro28-His507
Accession AAI13513.1
Mol_Mass 54.9 kDa
AP_Mol_Mass 60-90 kDa
Tag C-His

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 7.5.
Reconstitution Not Applicable

Background

Carnosine Dipeptidase 1 (CNDP1) belongs to the M20 metalloprotease family. CNDP1 is specifically expressed in the brain; serum and adult nervous central system. It is identified as human carnosinase. CNDP1 contains trinucleotide (CTG) repeat length polymorphism in the coding region and is inhibited by the metal chelator 1;10-o-phenantrolin. In addition; CNDP1 can hydrolyse the beta-Ala|-His dipeptide (carnosine); anserine; Xaa-|-His dipeptides and other dipeptides including homocarnosine. CNDP1 deficiency has been associated with homocarnosinosis disease.

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