Recombinant Human CTLA4 Protein (mFc Tag)

    • Recombinant Human CTLA4 / CD152 Protein (C-mFc)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human CTLA4 / CD152 Protein (C-mFc)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human CTLA4 / CD152 Protein (C-mFc)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033703

      Synonyms:Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;CTLA4;CD152;Cytotoxic T-Lymphocyte-Associated Protein 4

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $85

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      Overview

      Synonyms Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;CTLA4;CD152;Cytotoxic T-Lymphocyte-Associated Protein 4
      Species Human
      Expression_host Human Cells
      Sequence Lys36-Asp161
      Accession P16410
      Mol_Mass 40.1 kDa
      AP_Mol_Mass 45-55 kDa
      Tag C-mFc

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. Human or mouse CTLA4 cDNA encodes 223 amino acids (aa) including a 35 aa signal sequence, a 126 aa extracellular domain (ECD) with one Ig-like V-type domain, a 21 aa transmembrane (TM) sequence, and a 41 aa cytoplasmic sequence.It is widely expressed with highest levels in lymphoid tissues. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.

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      MSDS for ELISA ISO 9001

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