Recombinant Human Cyclophilin A Protein (His Tag) (PKSH031608)
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For research use only.
| Synonyms | Cyclophilin A, Cyclosporin A-binding protein, CYPA, Peptidyl-prolyl cis-trans isomerase A, PPIA, PPIase A, Rotamase A, SP18 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Glu 165 |
| Accession | P62937 |
| Calculated Molecular Weight | 19.4 kDa |
| Observed Molecular Weight | 19 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Form | Liquid |
| Purity | > 97 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as sterile 50mM Tris, 150mM NaCl, 20% glycerol, pH 7.7 |
| Background | Peptidyl-prolyl cis-trans isomerase A; also known as PPIase A; Rotamase A; Cyclophilin A; Cyclosporin A-binding protein; PPIA and CYPA; is a cytoplasm protein which belongs to thecyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins (CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. These molecules exhibit peptidyl-prolyl isomerase activity; suggesting that they influence the conformation of proteins in cells. PPIA / Cyclophilin A accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIA / Cyclophilin A is secreted by vascular smooth muscle cells in response to inflammatory stimuli; and could thus contribute to atherosclerosis. It is not essential for mammalian cell viability. PPIA / Cyclophilin A can interact with several HIV proteins; including p55 gag; Vpr; and capsid protein; and has been shown to be necessary for the formation of infectious HIV virions. |
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