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Recombinant Human DCR3/TNFRSF6B Protein (Fc Tag)(Active)

  • Cat.No.:PKSH031745

  • Expression host: Baculovirus-Insect Cells

To Purchase PKSH031745

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  • 100μg
  • 200μg
Price: $486
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Description

Synonyms DCR3;DJ583P15.1.1;M68;M68E;TNFRSF6B;TR6
Species Human
Expression_host Baculovirus-Insect Cells
Sequence Met 1-His300
Accession O95407
Mol_Mass 56.4 kDa
AP_Mol_Mass 65 kDa
Tag C-Fc
Bio_Activity Measured by its ability to inhibit Fas Ligand induced apoptosis of Jurkat human acute T cell leukemia cells.The ED50 for this effect is typically 0.01-0.05 μg/mL in the presence of 20 ng/mL recombinant human Fas Ligand.

Properties

Purity > 85 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile 100mM Glycine, 10mM NaCl, pH 7.0.
Reconstitution Please refer to the printed manual for detailed information.

Background

Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) also known as DcR3(Decoy Receptor 3) and M68 is the tumor necrosis factor receptor superfamily. DcR3/TNFRSF6B belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. DcR3/TNFRSF6B is detected in fetal lung, brain and liver. DcR3/TNFRSF6B is also detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. This protein is highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

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